GB/T 22603: Evolution and historical versions
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Tebuconazole wettable powder
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GB/T 22603-2025
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| GB 22603-2008 | English | 239 |
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[GB/T 22603-2008] Tebuconazole wettable powders
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GB 22603-2008
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Basic data | Standard ID | GB/T 22603-2025 (GB/T22603-2025) | | Description (Translated English) | Tebuconazole wettable powder | | Sector / Industry | National Standard (Recommended) | | Date of Implementation | 2026-03-01 | | Older Standard (superseded by this standard) | GB/T 22603-2008 | GB 22603-2008: [GB/T 22603-2008] Tebuconazole wettable powders---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Tebuconazole wettable powders
ICS 65.100.30
G25
National Standards of People's Republic of China
Tebuconazole WP
Posted 2008-12-17
2009-06-01 implementation
Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China
Standardization Administration of China released
Foreword
The standard Chapter 3, Chapter 5 is mandatory, the rest are recommended.
This standard FAO specification 494/WP/S/F (2000) "Tebuconazolewettablepowders" degree of non-conformity
Equivalent.
The standard proposed by China Petroleum and Chemical Industry Association.
This standard by the National Standardization Technical Committee on Pesticides (SAC/TC133) centralized.
This standard is drafted by. Shenyang Chemical Research Institute.
Participated in the drafting of this standard. Shandong Huayang Technology Co., Ltd. Jiangsu Feng Deng pesticides, Jiang Su Qizhou green chemical shares
Parts Co., Chemical Co., Ltd. Jiangsu dragon.
The main drafters of this standard. Jiangmin Yi, Li Xiujie, Bing-Wen, Gengrong Wei, Hu Chunhong, of cloud point.
Tebuconazole WP
The product is an active ingredient tebuconazole pent other name, structural formula and basic physicochemical parameters are as follows.
ISO common name. Tebuconazole
CAS Registry Number. 107534-96-3
CIPAC Numeric Code. 494
Chemical Name. (RS) -1- (4- chlorophenyl) -4,4-dimethyl -3- (1H-1,2,4- triazol-1-ylmethyl) pentan-3-ol
Structure.
Empirical formula. C16H22ClN3O
Molecular Weight. 307.8 (according to 2007 international relative atomic mass)
Biological activity. bactericidal
Melting point. about 102.4 ℃
Vapor pressure (20 ℃). 0.013mPa
Solubility (20 ℃). water 32mg/L; dichloromethane greater than 200g/L; hexane of less than 0.1g/L; isopropanol, toluene, 50g/L ~
100g/L
Stability. at pH 4 ~ 9,22 ℃ hydrolysis DT50 is greater than 1 year.
1 Scope
This standard specifies the tebuconazole WP requirements, test methods and marking, labeling, packaging, storage and transportation.
This standard applies to processed from Tebuconazole original drug, suitable additives and fillers made of tebuconazole WP.
2 Normative references
The following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent
Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research
Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard.
GB/T 1600 Determination of Water Pesticides
Determination of GB/T 1601 Pesticides pH value
GB/T 1604 Goods pesticide regulations for acceptance
GB/T 1605-2001 Sampling Method commercial pesticides
GB 3796 pesticide packaging General
GB/T 5451 WP Pesticide wettability measurement method
GB/T 14825-2006 Method for determination of pesticide suspension
GB/T 16150 pesticide powder, wettable powder fineness measurement method
GB/T 19136 Determination of Pesticide Thermal storage stability
3 Requirements
3.1 Composition and appearance. The product shall comply with Tebuconazole original drug with a suitable standard of processing additives and fillers made uniform loose powder,
There should be no lumps.
3.2 tebuconazole WP should meet the requirements of Table 1.
Table 1 tebuconazole WP Quality Control Project Index
project
index
80% 25%
Tebuconazole mass fraction /% 80.0 + 25.0 + 1.5-1.5 2.5-2.5
Moisture content /% ≤ 3.0
pH range 6.0 to 10.0
Suspension rate /% ≥ 75
Wetting time/s ≤ 90
Fineness (through 45μm test sieve) /% ≥ 98
Thermal storage stability test a qualified
When a normal production, heat storage stability test was measured at least once every three months.
Test Method 4
4.1 Sampling
According to GB/T 1605-2001 "on solid preparation sampling" approach. Determining sample package using a random number table method; the final sample size
Not less than 100g.
4.2 Identification Test
Liquid chromatography --- The identification test can be carried out simultaneously with the determination of the mass fraction of tebuconazole. Under the same chromatographic operating conditions, the test
The retention time of the sample solution and the standard solution to a peak of tebuconazole chromatographic retention time, the relative difference should be 1.5%
Fewer.
4.3 Determination of the mass fraction of tebuconazole
4.3.1 High performance liquid chromatography (Arbitration Act)
4.3.1.1 Method summary
Sample was dissolved in methanol, methanol + water as the mobile phase, use as filler in Nova-PakC18 stainless steel column and UV detector
(220nm), the sample of tebuconazole high performance liquid chromatography and determination.
4.3.1.2 Reagents and solutions
Methanol;
Water. The new secondary steam distilled water;
Tebuconazole Sample. Known tebuconazole mass fraction ≥99.0%.
4.3.1.3 Instruments
High performance liquid chromatography. a variable wavelength UV detector;
Chromatographic data processor;
Column. 150mm × 3.9mm (. I.d) stainless steel column, built-Nova-PakC185μm filler (or equivalent effect Chromatography
column);
Filter. filter pore size of about 0.45μm;
Micro injector. 50μL;
Quantitative sample line. 5μL;
Ultrasonic cleaner.
4.3.1.4 HPLC operating conditions
Mobile phase. ψ (CH3OH.H2O) = 65.35;
Flow rate. 1.0mL/min;
Column temperature. room temperature (temperature change should not exceed 2 ℃);
Detection wavelength. 220nm;
Injection volume. 5μL;
Retention time. tebuconazole about 7.0min.
It said operating parameters are typical, according to the characteristics of different instruments, given operating parameters adjusted as appropriate, in order to obtain the best results.
Typical tebuconazole WP HPLC is shown in Figure 1.
1 --- tebuconazole.
Figure 1 tebuconazole WP High Performance Liquid Chromatographic
4.3.1.5 Measurement procedure
4.3.1.5.1 Preparation of standard solution
Weigh 0.1g tebuconazole standard (accurate to 0.0002g), a 50mL volumetric flask, dilute to the mark with methanol, ultrasonic oscillation
5min make sample dissolution, cooled to room temperature and shake well. Using a pipette to take the above solution 5mL to 50mL volumetric flask, diluted with methanol to
Mark and shake.
4.3.1.5.2 Preparation of sample solution
Weigh 0.1g sample containing tebuconazole of (accurate to 0.0002g), a 50mL volumetric flask, dilute to the mark with methanol, ultrasonic
Oscillation 5min make sample dissolution, cooled to room temperature and shake well. Using a pipette to take the above solution 5mL to 50mL volumetric flask with methanol
Diluted to the mark, shake, filtration.
4.3.1.5.3 Determination
Under these operating conditions, after the instrument is stable, continuous injection of several doses of the standard solution until the two adjacent needles tebuconazole peak area relative change
After less than 1.5%, according to the solution, sample solution, sample solution, standard order of standard solution was measured.
4.3.1.5.4 Calculation
Tebuconazole sample mass fraction of 1 (%), according to equation (1).
1 =
(1)
Where.
A1 --- the standard solution, the average tebuconazole peak area;
The A2 --- sample solution, alcohol tebuconazole average peak area;
--- Tebuconazole standard mass fraction, expressed as a percentage.
4.3.1.6 allowable difference
The difference between two parallel determination results, 25% should be less than 0.5%, 80% should be less than 1.0%, measured as the arithmetic mean
result.
4.3.2 Capillary Gas Chromatography
4.3.2.1 Method summary
Sample was dissolved in chloroform, dicyclohexyl phthalate esters as internal standard, using a HP-5 (5% phenyl methyl silicone) coated quartz wool wall
Fine column, and a flame ionization detector, the sample of tebuconazole capillary gas chromatography and determination.
4.3.2.2 Reagents and solutions
Chloroform;
Tebuconazole standard. a known mass fraction ≥99.0%;
Dicyclohexyl phthalate ester. not interfere with the analysis of impurities;
Internal standard solution. Weigh 2.0g dicyclohexyl phthalate esters in 500mL volumetric flask, dissolved with chloroform, constant volume,
Shake well.
4.3.2.3 Instruments
Gas chromatograph. with flame ionization detector;
Column. 30m × 0.32mm (. I.d) quartz capillary column, wall coated HP-5 (5% phenyl methyl silicone), film thickness 0.25μm;
Chromatographic data processor or chromatography workstation.
4.3.2.4 GC operating conditions
Temperature (℃). Room 220 column, the gasification chamber 260, detection chamber 280;
Gas flow rate (mL/min). carrier gas (N2) 1.8, hydrogen gas 40, air 400, the compensation gas 25;
Split ratio. 40.1;
Injection volume. 1.0μL;
Retention time. tebuconazole about 7.5min, internal standard about 10.4min.
GC operating conditions described above, the Department of typical operating parameters. According to the characteristics of different instruments, given operating parameters adjusted as appropriate,
In order to obtain the best results. A typical gas chromatogram tebuconazole WP and the internal standard is shown in Figure 2.
1 --- tebuconazole;
2 --- internal standard.
Figure 2 tebuconazole wettable powder with a gas chromatograph internal standard
4.3.2.5 Measurement procedure
4.3.2.5.1 preparation of standard solution
Weigh tebuconazole standard 0.05g (accurate to 0.0002g), placed in a glass bottle stopper, with a pipette accurate internal standard was added 10mL
Solution, shake.
4.3.2.5.2 preparation of the sample solution
Weigh the sample containing tebuconazole 0.05g of (accurate to 0.0002g), placed in a glass bottle stopper, with the use and 4.3.2.5.1
With a pipette accurately added internal standard solution 10mL, shake, filtration.
4.3.2.5.3 Determination
Under the above chromatographic operating conditions, after the instrument is stable, continuous injection of several doses of the standard solution until the two adjacent needles tebuconazole and internal standard
After the change of the relative peak area ratio of less than 1.5%, according to the solution, the sample solution, the sample solution and standard sequence analysis of the standard solution
Determination.
4.3.2.5.4 Calculation
The two needle sample solution and measured before and after the two doses of the standard sample solution tebuconazole and the internal standard peak area ratio of the average, respectively.
Tebuconazole sample mass fraction of 1 '(%) according to equation (2).
1 '=
(2)
Where.
--- Standard samples tebuconazole mass fraction, expressed as a percentage.
4.3.2.6 allowable difference
The difference between two parallel determination results, 25% should be less than 0.5%, 80% should be less than 1.0%, measured as the arithmetic mean
result.
4.4 Determination of Moisture
According to GB/T 1600 in the "azeotropic distillation method".
According to GB/T 1601 carried out.
4.6 Determination of the suspension rate
4.6.1 Liquid Chromatography
According to GB/T 14825-2006 4.1 performed. Weigh 0.4g sample containing tebuconazole of (accurate to 0.0002g), the bottom of the cylinder
25mL suspension is fully transferred to 100mL volumetric flask with methanol to the mark, in the ultrasonic oscillating 3min, standing, after filtration,
4.3.1 Determination of mass tebuconazole calculate the suspension rate.
4.6.2 Gas Chromatography
According to GB/T 14825-2006 4.1 performed. Weigh 0.4g sample containing tebuconazole of (accurate to 0.0002g), the bottom of the cylinder
25mL and the whole suspension was transferred to a 100mL beaker, and the same one used 4.3.2.5.1 pipette accurately the added 10mL
Standard solution, then add 10mL of chloroform, in the ultrasonic oscillating 3min, standing, after filtration, measured according to 4.3.2 tebuconazole quality meter
Operators suspended rate.
4.7 Determination of wetting time
According to GB/T 5451 carried out.
4.8 Determination of fineness
According to GB/T 16150 in the "wet sieve method".
4.9 Thermal storage stability test
According to GB/T 19136 in "powder formulations" to. After the heat storage tebuconazole content should not be less than the reservoir before the mass fraction of tebuconazole
97% suspension rate should meet the standard requirements.
4.10 Product inspection and acceptance
Product inspection and acceptance shall comply with GB/T 1604's. Treatment of extreme values, using the rounding value comparison method.
5 marking, labeling, packaging, storage and transportation
5.1 tebuconazole WP signs, labeling and packaging should comply with the provisions of GB 3796.
5.2 tebuconazole WP application bag lined with clean plastic bag or cardboard drum lined with clean plastic bags, each containing a net weight
Generally not more than 15kg. Also available upon request or order agreement, the use of other forms of packaging, it should comply with the provisions of GB 3796.
5.3 tebuconazole WP package should be stored in well-ventilated, dry coffers.
5.4 storage, prevent moisture and sunlight, no food, seed, feed mix, avoid contact with skin, eyes, mouth and nose to prevent inhalation.
5.5 Security. This product is a fungicide. Are swallowed and inhaled toxic, it can penetrate through the skin. Wear protective goggles and rubber gloves when using this product wear
Necessary protective clothing. After spraying wash with soap and water. Coverage should be immediately sent to hospital symptomatic treatment.
5.6 Warranty. under the specified storage conditions, tebuconazole guarantee of wettable powders, starting from the date of manufacture 2 years.
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