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SN/T 2241-2008: Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test
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| Standard ID | Contents [version] | USD | STEP2 | [PDF] delivered in | Standard Title (Description) | Status | PDF |
| SN/T 2241-2008 | English | 169 |
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Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test
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SN/T 2241-2008
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Basic data | Standard ID | SN/T 2241-2008 (SN/T2241-2008) | | Description (Translated English) | Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test | | Sector / Industry | Commodity Inspection Standard (Recommended) | | Classification of Chinese Standard | C70 | | Word Count Estimation | 6,695 | | Date of Issue | 2008-11-18 | | Date of Implementation | 2009-06-01 | | Quoted Standard | GB 14924.1; GB 14925; Ministry of Health, "chemical toxicity identified technical specifications" (2005) | | Adopted Standard | OECD No.422-1996, MOD | | Regulation (derived from) | National Quality Inspection [2008] No. 577 | | Issuing agency(ies) | General Administration of Customs | | Summary | This standard specifies the joint breeding animals subacute toxicity/developmental toxicity screening test definitions of terms, test methods and results of clinical examination and report. This standard is applicable to the detection of chemicals subacute toxicity, reproductive toxicity and growth effects. | SN/T 2241-2008: Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test
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Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test
Exit inspection and quarantine industry standard book People's Republic of China
Combined with repeated dose toxicity study
Reproductive and developmental toxicity screening test
Posted 2008-11-18
2009-06-01 implementation
People's Republic of China
The State Administration of Quality Supervision, Inspection and Quarantine released
Foreword
This revised standard adopts the United Nations Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 422 "The combination Repeated dose toxicity
Reproductive and developmental toxicity screening test research "(1996).
This standard OECD Chemicals Test Method No. 422 compared with the following differences.
--- To OECD Chemicals Test Method No. 422 were editorial changes;
--- Increase the preamble.
This standard was proposed by the State Administration of Quality Supervision, Inspection and Quarantine.
This standard by the National Certification and Accreditation Administration Committee.
This standard is drafted by. People's Republic of China Tianjin Exit Inspection and Quarantine.
Participated in the drafting of this standard. the Chemical Institute of Standardization, Jiangnan University and Tianjin Inspection and Quarantine Institute of Science and Technology.
The main drafters of this standard. good Lippo Zhao, Zhang Yuan, Li Xue Yang, in Chi Rui, Zhao Lihua, Zhou Lei.
This standard is the first release of the entry-exit inspection and quarantine industry standards.
Combined with repeated dose toxicity study
Reproductive and developmental toxicity screening test
1 Scope
This standard specifies the joint animal subacute toxicity Reproductive/developmental toxicity screening test definitions of terms, test methods and clinical examination and knot
If the report.
This standard applies to detect chemicals subacute toxicity, reproductive toxicity and Growth.
2 Normative references
The following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent
Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research
Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard.
GB 14924.1 animal feed common quality standards
GB 14925 Laboratory Animal Facilities and Environment
The Ministry of Health "toxic chemicals identified technical specifications" (2005)
3 Terms and Definitions
The following terms and definitions apply to this standard.
3.1
On parental reproductive functions or capacity and (or) damage effects on offspring growth and development of the test sample.
3.2
Parent female pregnant animals cause direct or indirect damage to health effects.
3.3
Performance barriers female or male animal reproductive function or capability.
3.4
Contacting the test sample pregnant animals caused offspring before birth, perinatal and postnatal the body showing defects or dysfunction.
4 test animals
4.1 rearing environment
According to GB 14924.1 and GB 14925 requirements.
4.2 Animal Selection
Should choose a healthy young adult rats, without a mate, did not participate in any trial. Avoid using low fertility and the high rate of growth and developmental defects
strain. Initial test, animals should not exceed 20% of the weight of the average weight of the same sex. If the test is divided into formal pre-test and test, used
Strains and animal origin should be the same. The selected animals should indicate species, strain, sex, weight, and (or) weeks. 7 weeks to best use
8 weeks old, at least 5 days after the adaptation of animals. Female animals must not have been produced Aberdeen.
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