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SN/T 2182-2008: Two-generation reproduction toxicity test
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| SN/T 2182-2008 | English | 169 |
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Two-generation reproduction toxicity test
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SN/T 2182-2008
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Basic data | Standard ID | SN/T 2182-2008 (SN/T2182-2008) | | Description (Translated English) | Two-generation reproduction toxicity test | | Sector / Industry | Commodity Inspection Standard (Recommended) | | Classification of Chinese Standard | C70 | | Classification of International Standard | 13.300 | | Word Count Estimation | 6,629 | | Date of Issue | 2008-09-04 | | Date of Implementation | 2009-03-16 | | Quoted Standard | GB 14924.1; GB 14925 | | Adopted Standard | OECD NO.416-2001, MOD | | Issuing agency(ies) | General Administration of Customs | | Summary | This standard specifies the two-generation reproduction toxicity test animals terminology and definitions, test animals, the test substance and grouping, test procedures, test results evaluation, test results reporting and interpretation of test results. This standard applies to reproductive toxicity testing of chemicals. | SN/T 2182-2008: Two-generation reproduction toxicity test---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Two-generation reproduction toxicity test
Exit inspection and quarantine industry standard book People's Republic of China
Two-generation reproduction toxicity test
Posted 2008-09-04
2009-03-16 implementation
People's Republic of China
The State Administration of Quality Supervision, Inspection and Quarantine released
Foreword
This revised standard adopts the United Nations Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 416 "two-generation reproduction toxicity test
Test "(1983,2001 English).
This standard OECD Chemicals Test Method No. 416 compared with the following differences.
--- To OECD Chemicals Test Method No. 416 were editorial changes;
--- Increased the preamble;
--- Increasing the breeding index calculation method.
This standard was proposed by the State Administration of Quality Supervision Inspection and Quarantine of People's Republic of China.
This standard by the National Certification and Accreditation Administration Committee.
This standard is drafted by. People's Republic of China Tianjin Exit Inspection and Quarantine.
Participated in the drafting of this standard. the Chemical Institute of Standardization, Jiangnan University, Tianjin Academy of Inspection and Quarantine Science and Technology.
The main drafters. Zhang Yuan, in Yanjun, Zhao Zhuo, in Chi Rui, Zhou Lei, Xiong Zhongjiang.
This standard is the first release of the entry-exit inspection and quarantine industry standards.
Two-generation reproduction toxicity test
1 Scope
This standard specifies the terms and definitions animal generation reproduction toxicity test, test animals, the test substance and grouping, test procedures, test results
Evaluation of the test results and report test results interpretation.
This standard applies to the detection of chemicals reproductive toxicity.
2 Normative references
The following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent
Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research
Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard.
GB 14924.1 animal feed common quality standards
GB 14925 Laboratory Animal Facilities and Environment
3 Terms and Definitions
The following terms and definitions apply to this standard.
3.1
Female parent or damage caused by chemicals is reduced male reproductive function or fertility, such as the decline in reproductive rates; or cause progeny
Non-hereditary adverse effects, such as growth and developmental toxicity, including teratogenic effects of damage to health and the breast-feeding period.
3.2
Performance barriers female or male animal reproductive function or capability.
3.3
Contacting a test sample of pregnant animals offspring before birth, perinatal and after the birth of the body showing defects or dysfunction.
4 test animals
Rat or mouse are the preferred species, experimental and control groups should have sufficient quantities to guarantee access to approximately 20 pregnant rats. Animal feed
Nutrition and the environment according to the requirements of GB 14924.1 and GB 14925 was. Parent before the test began in the cage at least keeping 5d to adapt to the environment.
5 test substance and grouping
5.1 test substance
All of the animals exposed to the test using the same method. If there is a solvent or other excipients for exposure, which is known to be non-toxic
of. Weekly press 7d administration.
5.2 Packet
We should at least have three exposed groups, a control group. The highest dose should not lead to lead poisoning but parental death of the animal. Ideal intermediate
Dose to cause slight toxic effects, while the low dose does not cause the parent and offspring observed harmful effects to. If the capsules or oral exposure,
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