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SN/T 2164-2008: Test method of acute oral toxicity. Fixed dose method for dangerous goods
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| SN/T 2164-2008 | English | 339 |
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Test method of acute oral toxicity. Fixed dose method for dangerous goods
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SN/T 2164-2008
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Basic data | Standard ID | SN/T 2164-2008 (SN/T2164-2008) | | Description (Translated English) | Test method of acute oral toxicity. Fixed dose method for dangerous goods | | Sector / Industry | Commodity Inspection Standard (Recommended) | | Classification of Chinese Standard | C70 | | Classification of International Standard | 13.300 | | Word Count Estimation | 13,154 | | Date of Issue | 2008-09-04 | | Date of Implementation | 2009-03-16 | | Quoted Standard | GB 14924.1; GB 14925 | | Adopted Standard | OECD NO.420-2001, MOD | | Issuing agency(ies) | General Administration of Customs | | Summary | This standard specifies the dangerous chemicals acute oral toxicity test principles and procedures, test procedures, data and reporting, and interpretation of results. This standard applies to hazardous chemicals Determination of acute oral toxicity. | SN/T 2164-2008: Test method of acute oral toxicity. Fixed dose method for dangerous goods---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Test method of acute oral toxicity.Fixed dose method for dangerous goods
Exit inspection and quarantine industry standard book People's Republic of China
Dangerous goods acute oral toxicity
Fixed-dose test methods
Posted 2008-09-04
2009-03-16 implementation
People's Republic of China
The State Administration of Quality Supervision, Inspection and Quarantine released
Foreword
This revised standard adopts the United Nations Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 420 "Acute oral toxicity. solid
Dosing Law "(2001).
This standard OECD Chemicals Test Method No. 420 compared with the following differences.
--- To OECD Chemicals Test Method No. 420 were editorial changes;
--- Increased the preamble;
--- Added Appendix section.
The Standard Appendix A, Appendix B and Appendix C are normative appendix.
This standard was proposed by the State Administration of Quality Supervision Inspection and Quarantine of People's Republic of China.
This standard by the National Certification and Accreditation Administration Committee.
This standard is drafted by. People's Republic of China Tianjin Exit Inspection and Quarantine.
Participated in the drafting of this standard. Jiangnan University, the Chemical Institute of Standardization, Tianjin Inspection and Quarantine Institute of Science and Technology.
The main drafters of this standard. Lining Tao, Zhang Yuan, Pang Zhen, Li Xue Yang, in Chi Rui, Zhao Zhuo.
This standard is the first release of the entry-exit inspection and quarantine industry standards.
Dangerous goods acute oral toxicity
Fixed-dose test methods
1 Scope
This standard specifies the test principles and procedures of hazardous chemicals acute oral toxicity test, the test procedure and interpretation of results and reporting data.
This standard applies to the determination of acute oral toxicity of hazardous chemicals.
2 Normative references
The following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent
Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research
Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard.
GB 14924.1 animal feed common quality standards
GB 14925 Laboratory Animal Facilities and Environment
3 Terms and Definitions
The following terms and definitions apply to this standard.
3.1
The test was carried out within 24h deleterious effects of a case of oral or repeated oral exposure arising to test animals.
3.2
Animals given the amount of exposure of the test substance, also known as (a) dose, often animal subject of substance per kilogram of body weight (ie mg/kg body weight)
Which represents the amount of exposure; such as when the test was incorporated into the feed were fed infected, often at a ratio of test substance concentrations (mg/kg or mg/L) Table
Shown. Quality of material including exposure, exposure frequency and duration of exposure per day in general.
3.3
Animals give clear test substance toxicity after exposure. These toxicity sufficient for hazard assessment and prediction can produce serious
Heavy toxicity and death may occur.
4 Test principle and procedure
4.1 Test Principle
In formal tests use only moderately toxic doses, do not use lethal dose, not chosen by corrosion or severe irritation caused or
Notify significant pain or suffering exposure dose. When testing the toxicity, if we find the animal significant pain or suffering of serious disease
When the state, from the principles of humanity will be sacrificed.
4.2 Test Procedure
Test groups use the same sex (generally female) animals, a fixed dose spacing (5mg/kg, 50mg/kg, 300mg/kg and
2000mg/kg, if there are special needs to consider 5000mg/kg) were orally exposed sequentially. The selected dose range should pre-test that,
And it should be expected to occur just below the dose lethal. If no toxicity is observed in the selected dose confirmation, you should choose the next higher
High-dose acute toxicity test. If you have seen the animal death or serious toxicity at the starting dose, from animal welfare test
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