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Laboratory animal - Rules for nomenclature of mouse and rat strains
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GB/T 39650-2020
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Basic data | Standard ID | GB/T 39650-2020 (GB/T39650-2020) | | Description (Translated English) | Laboratory animal - Rules for nomenclature of mouse and rat strains | | Sector / Industry | National Standard (Recommended) | | Classification of Chinese Standard | B44 | | Classification of International Standard | 65.020.30 | | Word Count Estimation | 14,166 | | Date of Issue | 2020-12-14 | | Date of Implementation | 2020-12-14 | | Quoted Standard | GB 14923 | | Regulation (derived from) | National Standard Announcement No. 28 of 2020 | | Issuing agency(ies) | State Administration for Market Regulation, China National Standardization Administration | | Summary | This standard specifies the naming rules for experimental animal mouse and rat strains, including genetic classification of experimental animals, laboratory codes, inbred lines, inbred lines from multiple sources, homologous mutation inbred lines, and homologous inbred lines. The naming of crossed and separated inbred lines, the naming of closed groups (outbred groups) and hybrid groups. This standard applies to the naming of experimental animal mouse and rat strains. |
GB/T 39650-2020: Laboratory animal - Rules for nomenclature of mouse and rat strains---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
(Laboratory animals Mouse and rat strain naming rules)
ICS 65:020:30
B44
National Standards of People's Republic of China
The naming rules of experimental animal mouse and rat strain
2020-12-14 release
2020-12-14 implementation
State Administration for Market Regulation
Issued by the National Standardization Management Committee
Foreword
This standard was drafted in accordance with the rules given in GB/T 1:1-2009:
This standard was proposed and managed by the National Laboratory Animal Standardization Technical Committee (SAC/TC281):
Drafting organizations of this standard: Institute of Medical Laboratory Animals, Chinese Academy of Medical Sciences, China Institute for Food and Drug Control, Shandong Laboratory
Center for Medical Sciences, Xi’an Jiaotong University, Beijing Jishuitan Hospital, Laboratory Animal Center of China Center for Disease Control and Prevention, Shanghai Municipal Office of Fudan University
Public Health Clinical Center, Occupational Hygiene and Poisoning Control Institute of Chinese Center for Disease Control and Prevention, Chinese Center for Disease Control and Prevention
Health:
The main drafters of this standard: Qin Chuan, Kong Qi, Yue Bingfei, Wei Qiang, Jin Dongqing, Liu Enqi, Zhao Danhui, Gao Hong, Lu Xuancheng, Zhou Xiaohui, Li Junyan,
Wang Zhu, Shao Qiming, Xiang Zhiguang:
Introduction
There are many strains of experimental animals, mice and rats, which come from different laboratories all over the world, and their genetic backgrounds are quite different: Various mice and rats
The standardized naming of strains is very important for cultivating and using these mice and rats worldwide: Especially between individuals of the same strain
There is also the possibility of genetic drift, and the same strains cultivated in different laboratories should also be distinguished:
This standard refers to the International Committee on Mouse Standardized Genetic Naming (InternationalCommitteeon Standardized Genetic
NomenclatureforMice) formulated the "Mice and Rat Strain Naming Guidelines" (revised in January:2016):
The naming rules of experimental animal mouse and rat strain
1 Scope
This standard specifies the naming rules for experimental animal mouse and rat strains, including the genetic classification of experimental animals, laboratory codes, and inbreeding
Lines, multiple source inbred lines, homologous mutant inbred lines, homologous introduction inbred lines and isolated inbred lines, closed group (outbred group) and hybrid group
Naming:
This standard applies to the naming of experimental animal mouse and rat strains:
2 Normative references
The following documents are indispensable for the application of this document: For dated reference documents, only the dated version applies to this article
Pieces: For undated references, the latest version (including all amendments) applies to this document:
GB 14923 Laboratory Animals Genetic Quality Control of Mammals Laboratory Animals
3 Terms and definitions
The following terms and definitions defined in GB 14923 apply to this document:
3:1
Segregatinginbredstrains
Through inbred breeding (usually sibling mating), each generation performs heterozygosity screening to isolate inbred lines to make a specific allele or mutation
An inbred line that remains heterozygous:
3:2
Colaborative crossstrains; CC; GC
Contains from 8 progenitor lines (A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, NZ/HILtJ, CAST/EiJ, PWK/
PhJ and WSB/EiJ) genetic genes: The funnel breeding strategy is adopted to incorporate all 8 ancestral lines into 3 breeding populations, and successive generations of brothers
A multi-parental recombinant inbred line derived from the mating of sisters:
4 Classification of laboratory animal genetics
According to the different breeding methods and genetic characteristics of experimental animals, the classification is as follows:
a) Inbred strains:
1) Recombinantinbredstrains, RI;
2) Recombinant congenicstrains, RC;
3) Colaborative crossstrains, CC, GC;
4) Mixed systems mixedinbredstrains, MI;
5) Advanced intercrosslines, AIL;
6) Homologous mutation inbred lines coisogenicinbredstrains;
7) Homologous introduction of inbred lines (same inbred lines) congenicinbredstrains;
8) Chromosome substitution system consomicstrainsorchromosomesubstitutionstrains;
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