GB/T 21610: Evolution and historical versions
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Chemicals - Test method of rodent dominant lethal
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| GB/T 21610-2008 | English | 169 |
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Test method of rodent dominant lethal for chemicals
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Basic data | Standard ID | GB/T 21610-2025 (GB/T21610-2025) | | Description (Translated English) | Chemicals - Test method of rodent dominant lethal | | Sector / Industry | National Standard (Recommended) | | Date of Implementation | 2025-12-01 | | Older Standard (superseded by this standard) | GB/T 21610-2008 | GB/T 21610-2008: Test method of rodent dominant lethal for chemicals---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Test method of rodent dominant lethal for chemicals
ICS 13.300; 11.100
A80
National Standards of People's Republic of China
Chemicals Rodent dominant lethal test methods
Posted 2008-04-01
2008-09-01 implementation
Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China
Standardization Administration of China released
Foreword
This revised standard adopts the United Nations Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 478 "Rodent dominant cause
Death Test "(1997) (in English).
This standard OECD Chemicals Test Method No. 478 compared with the following differences.
--- To OECD Chemicals Test Method No. 478 were editorial changes;
--- Increased the preamble;
--- Rearing environment contextually GB 14924-2001 and GB 14925-2001 provisions.
This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points.
This standard is drafted by. China Center for Disease Control and Prevention of Occupational Health and Poison Control.
Participated in the drafting of this standard. Tianjin Inspection and Quarantine Institute of Science and Technology, Hunan labor health occupational disease prevention.
The main drafters of this standard. Ai Wei Wu, Chao-lin, Xu Jianning, Zheng Lin, Sun Jinxiu Shi Xiao , Zhang Yuan, in Chi Rui, Lining Tao, Lu Dan.
Chemicals Rodent dominant lethal test methods
1 Scope
This standard specifies the test object, the terms and definitions, basic test principle, test procedures Rodent dominant lethal test results Review
Price, test reports and interpretation of results.
This standard is applicable to the detection of chemical damage to the overall rodent germ cell chromosomes.
2 Normative references
The following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent
Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research
Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard.
GB 14924-2001 standard laboratory animals and feed
GB 14925-2001 Laboratory Animal Facilities and Environment
Chemical Abstracts Registry Number CAS No. 50-18-0
Chemical Abstracts Registry Number CAS No. 51-18-3
Chemical Abstracts Registry Number CAS No. 62-50-0
Chemical Abstracts Registry Number CAS No. 6055-19-2
3 Terms and Definitions
3.1
It means causing the embryo or fetal death. When this effect was produced by exposure to a chemical test sample showed reproductive effects in laboratory animals
Organizations, generally considered to be a result cause reproductive changes in chromosome structure and number of cells. Does not rule out gene mutations and toxic effects.
3.2
Refers to the development of sperm or eggs in the physical or chemical factors, chromosomal damage occurs, thus resulting in the development of a fertilized egg
death. Fertilization does not cause disorder, but cause of death of a fertilized egg.
4 test purposes
This trial is a germ cell mutagenicity test for detecting the overall rodent germ cells chromosomal aberrations, further confirmed the body
Field test, or other test systems to obtain positive results in order to evaluate the test sample can reach the gonads produce genetic damage.
5 Test Fundamentals
Through appropriate means to make contact with a test sample of male animals, and then exposed and not without a mated female animals mating, mating end
After removing the female animals. Female animals were sacrificed after half of pregnancy, cut open the abdominal cavity, the uterus is removed, check the number of implants on both sides of the uterus (implantation
Number), as early as the number of stillbirths and late stillbirth numbers and number of live births. Male animal is in a certain interval of time and then another group without the exposure and not mated
Female animals mate, so a total number of batches, to ensure that the sperm cover a period (6 weeks to 9 weeks).
6 Test Procedure
6.1 test sample
The test sample should be freshly prepared. Unless there is information to indicate that this solution (or emulsion, suspension, etc.) preservation of stability. Solid test
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