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SN/T 4577-2016: Skin irritation test for cosmetics--Reconstructed human epidermal model in vitro alternative method
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| Standard ID | Contents [version] | USD | STEP2 | [PDF] delivered in | Standard Title (Description) | Status | PDF |
| SN/T 4577-2016 | English | 229 |
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Skin irritation test for cosmetics--Reconstructed human epidermal model in vitro alternative method
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SN/T 4577-2016
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Basic data | Standard ID | SN/T 4577-2016 (SN/T4577-2016) | | Description (Translated English) | Skin irritation test for cosmetics--Reconstructed human epidermal model in vitro alternative method | | Sector / Industry | Commodity Inspection Standard (Recommended) | | Classification of Chinese Standard | Y42 | | Word Count Estimation | 10,166 | | Date of Issue | 2016-08-23 | | Date of Implementation | 2017-03-01 | | Regulation (derived from) | State-Quality-Inspection-Certification (2016)438 | | Issuing agency(ies) | General Administration of Customs | SN/T 4577-2016: Skin irritation test for cosmetics--Reconstructed human epidermal model in vitro alternative method
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(Cosmetic skin irritation detection method for reconstructing human epidermis models in)
People's Republic of China Entry-Exit Inspection and Quarantine Industry Standard
Cosmetic skin irritation test
In vitro test method for reconstructing human skin model
Published on.2016-08-23
2017-03-01 implementation
People's Republic
The General Administration of Quality Supervision, Inspection and Quarantine issued
Entry and exit inspection and quarantine
Industry Standard
Cosmetic skin irritation test
In vitro test method for reconstructing human skin model
China Standard Press Publishing
First edition, January.2018
Foreword
This standard was drafted in accordance with the rules given in GB/T 1.1-2009.
This standard refers to the Chemical Testing Guide No. 439 (OECDGuidelinesfor) issued by the Organization for Economic Co-operation and Development.
Please note that some of the contents of this document may involve patents. The issuing organization of this document is not responsible for identifying these patents.
This standard is proposed and managed by the National Certification and Accreditation Administration.
This standard was drafted. Beijing Entry-Exit Inspection and Quarantine Bureau of the People's Republic of China, China Academy of Inspection and Quarantine, and the Chinese People
Heguo Guangdong Entry-Exit Inspection and Quarantine Bureau, Shanghai Entry-Exit Inspection and Quarantine Bureau of the People's Republic of China, L'Oreal China R&D and Innovation Center.
The main drafters of this standard. Zeng Jing, Ma Dan, Suning, Cheng Shujun, Qiu Yi, Cai Yizi, Zheng Hongyan, Wei Haiyan, Qin Yao, Li Xiaolin, Zhao Wei,
Li Nan.
Cosmetic skin irritation test
In vitro test method for reconstructing human skin model
1 Scope
This standard specifies the in vitro test method for the stimulation of human skin by cosmetic and cosmetic raw materials.
This standard applies to the safety testing of cosmetic and cosmetic raw materials.
2 Normative references
The following documents are indispensable for the application of this document. For dated references, only dated versions apply to this article.
Pieces. For undated references, the latest edition (including all amendments) applies to this document.
GB/T 6682 Analytical laboratory water specifications and test methods
3 Terms, definitions and abbreviations
3.1 Terms and definitions
The following terms and definitions apply to this document.
3.1.1
Alternative alternatives
Improve test design and increase test efficiency to reduce animal stress (optimized replacement) and reduce the number of animals required for a certain trial (reduced
Alternative), as well as the use of animals that have completely stopped a test (instead of substitution), and studies conducted to achieve the above objectives.
3.1.2
Alternative test alternativestesting
Use lower animals or use isolated organs, cultured cells or organelles, bio-simulation systems to optimize, reduce or replace traditional movements
Physical tests, toxicological evaluation, efficacy evaluation and other life science research.
3.1.3
In vitro test invitrotesting
Experiments with cells or tissues cultured in vitro.
3.1.4
Reconstructed human epidermal model reconstructedhumanepidermalskin
Using human skin-derived cells to reconstruct three-dimensional structures using tissue engineering techniques, structures and structures similar to normal skin can be obtained.
Features. In vitro reconstruction of the epidermal model can better simulate the actual exposure of human body to exogenous chemicals, and can be used to replace live animals.
experiment.
3.2 Abbreviations
The following abbreviations apply to this document.
MTT[3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenylTetrazoliumBromide]
3-(4,5-Dimethyl-2-thiazole)-2,5-diphenyltetrazolium bromide blue, Chinese abbreviation thiazole blue.
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