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GB/T 21770-2008: Chemicals (organophosphorus substances) -- Test method of delayed neurotoxicity following acute exposure
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| GB/T 21770-2008 | English | 189 |
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Chemicals (organophosphorus substances) -- Test method of delayed neurotoxicity following acute exposure
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GB/T 21770-2008
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Basic data | Standard ID | GB/T 21770-2008 (GB/T21770-2008) | | Description (Translated English) | Chemicals (organophosphorus substances) -- Test method of delayed neurotoxicity following acute exposure | | Sector / Industry | National Standard (Recommended) | | Classification of Chinese Standard | A80 | | Classification of International Standard | 13.300; 11.100 | | Word Count Estimation | 8,862 | | Date of Issue | 2008-05-12 | | Date of Implementation | 2008-09-01 | | Adopted Standard | OECD No.418-1995, IDT | | Regulation (derived from) | Announcement of Newly Approved National Standards No. 7, 2008 (No. 120 overall) | | Issuing agency(ies) | General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China | | Summary | This standard specifies the chemical contamination of acute organophosphorus compounds delayed neurotoxicity animal testing scope, definitions of terms and abbreviations, testing basic principles, test methods, test data and reports. This standard is applicable to the detection of organophosphorus compounds after acute exposure delayed neurotoxic effects. | GB/T 21770-2008: Chemicals (organophosphorus substances) -- Test method of delayed neurotoxicity following acute exposure
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Chemicals (organophosphorus substances). Test method of delayed neurotoxicity following acute exposure
ICS 13.300; 11.100
A80
National Standards of People's Republic of China
Chemicals (organophosphorus compound) Acute exposure delayed
Neurotoxicity Test Method
Posted 2008-05-12
2008-09-01 implementation
Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China
Standardization Administration of China released
Foreword
This standard is identical with the Organisation for Economic Co-operation and Development (OECD) Chemicals testing guidelines No. 418 (1995), "an organic phosphorus compound
Acute exposure delayed neurotoxicity tests "(in English).
The editorial changes made the following standard.
--- Increasing the scope section;
--- Change the unit of measure of legal units of measurement;
--- Deleted the reference section of the OECD.
This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points.
This standard is drafted by. China Center for Disease Control and Prevention of Occupational Health and Poison Control.
Participated in the drafting of this standard. Ningbo Exit Inspection and Quarantine, the State Environmental Protection Administration Chemical Registration Center, China Environmental Science
Research Institute, Shenyang Chemical Research Institute Center for Safety Evaluation.
The main drafters of this standard. Li Tao, Sun Jinxiu, then Long Hao, Li Tao, Ma Zhongchun, Chen Xiaoqing, Lin Zhenxing.
OECD Introduction
1. OECD will regularly modify their chemical testing guidelines based on considerations of scientific development and animal welfare. This update guidelines adopted
Modified method, including measuring neurological disease target esterase (NTE; formerly known neurotoxic esterase) to determine the effect of sufficiently high doses, and
21d no longer require repeated exposure. 24h ~ 48h after exposure on the brain and spinal cord NTE inhibition and 10d ~ 20d after seeing
Clinical and morphological effects of delayed neurotoxicity have a good correlation. NTE test model has been found for all known to cause human
Delayed neuropathy organophosphate substances are valid. Thus, the quantitative data NTE inhibition of behavior or sometimes pathological
Learn some ambiguous results seen whether the show is a potential delayed neurotoxic substances, significantly improve the ability to judge.
2. The chemical test guidelines 418 from an updated version of the Expert Working Group in February 1992, held in Paris on short-term systemic
And (Delayed) Neurotoxicity coordination meetings. This updated version is mainly based on the relevant OECD God in March 1990, held in Washington
After the special session to discuss the formation of toxicity tests on the basis of the preliminary and revised from Member States on the comments received.
3. In assessing the effects and toxicity evaluation of chemical substances, taking into account certain types of chemicals have caused certain types of nerve poison
Potential resistance, which is not possible to detect toxic effects in other toxicity studies, and this is very important. View now
Observed certain organic phosphorus compound can cause delayed neurotoxicity, therefore, such chemicals should use this guide as a candidate material was evaluated
estimate. In addition, in vitro screening tests may be used to identify those that can cause delayed polyneuropathy chemicals. However, in vitro studies eligible
Negative results obtained do not provide sufficient evidence to explain the test chemical is not neurotoxic substances.
4. Negative results toxicity endpoints (biochemistry, histopathology and behavioral observation) in this test guide selected obtained in normal circumstances
Without requiring further delayed neurotoxicity tests. For those endpoints as suspicious or inconclusive results, you need to enter
Step evaluation.
Chemicals (organophosphorus compound) Acute exposure delayed
Neurotoxicity Test Method
1 Scope
This standard specifies the chemical organophosphorus compounds acute poisoning delayed neurotoxicity animal testing, definitions of terms and abbreviations
Language, the basic principles of the test, test methods, test data and reports.
This standard applies to the neurotoxic effects of delayed detection of organic phosphorus compound after acute exposure.
2 Terms and definitions, abbreviations
2.1 Terms and Definitions
The following terms and definitions apply to this standard.
2.1.1
It refers to a group of neurological syndromes, mainly for ataxia delay the onset of, spinal cord and peripheral nerve axons distal disease, and nerve
Organization neurological disease target esterase inhibition and aging.
2.1.2
It includes uncharged organic phosphate, phosphorothioate, or an organic phosphoric anhydride, organic phosphonic acid, organic phosphoric acid - amide or related thiophosphate
Acid, thio acid or thio acid phosphoramidite, or other cause delayed neurotoxicity of certain substances.
2.2 Acronyms
The following abbreviations apply to this standard.
AChE (acetylcholinesterase) acetylcholinesterase
NTE (neuropathytargetesterase) neurological disease target esterase
TOCP (tri-o-cresylphosphate) tricresyl phosphate
3 test basic principles
A test substance dose oral administration of domesticated hen, but to advance the protection of domestic hens of protection from acute cholinergic effects. Observation move
Was 21d, including behavioral abnormalities, ataxia, and paralysis. Animals from each group were randomly selected biochemical tests (usually after exposure and 24h
48h), especially NTE detection. The first 21 days after exposure, the remaining animals were sacrificed, select nerve tissue for histopathological examination.
Test Method 4
4.1 Experimental Animals
4.2 animal species
Use Healthy young adult, 8 months to 12 months of house laying hens (Galusgalus domesticated species). Commonly used large hen
Small, species and strains to meet the standard animal feeding should grow up under conditions of free movement.
4.2.1 rearing environment
Animal cages or fences should be large enough to allow free movement of the hens and easy observation of gait animals. When the breeding environment is artificial light
When the photos, to be recycled in accordance with 12h light/12h dark order. To provide a suitable feed, free drinking water.
4.2.2 Animal Preparation
Use Healthy young adult hens, to ensure that no infected with viral diseases have not received medication and no abnormal gait, which
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