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GB/T 21764-2008: Chemicals -- Test method of sub-chronic dermal toxicity study
Status: Valid
| Standard ID | Contents [version] | USD | STEP2 | [PDF] delivered in | Standard Title (Description) | Status | PDF |
| GB/T 21764-2008 | English | 134 |
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Chemicals -- Test method of sub-chronic dermal toxicity study
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GB/T 21764-2008
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Basic data | Standard ID | GB/T 21764-2008 (GB/T21764-2008) | | Description (Translated English) | Chemicals -- Test method of sub-chronic dermal toxicity study | | Sector / Industry | National Standard (Recommended) | | Classification of Chinese Standard | A80 | | Classification of International Standard | 13.300; 11.100 | | Word Count Estimation | 7,744 | | Date of Issue | 2008-05-12 | | Date of Implementation | 2008-09-01 | | Adopted Standard | OECD No.411-1981, IDT | | Regulation (derived from) | Announcement of Newly Approved National Standards No. 7, 2008 (No. 120 overall) | | Issuing agency(ies) | General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China | | Summary | This standard specifies the rodent subchronic dermal toxicity test scope, terms and definitions, test basic principles, test methods, test data and reports. This standard applies to detect chemicals subchronic dermal toxicity tests. Acute toxicity test to get through the preliminary test substance toxicity data after subchronic dermal toxicity determination to provide the specified test period repeated exposure through the skin and cause a potential health hazard information. | GB/T 21764-2008: Chemicals -- Test method of sub-chronic dermal toxicity study---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Chemicals. Test method of subchronic dermal toxicity study
ICS 13.300; 11.100
A80
National Standards of People's Republic of China
Chemicals subchronic dermal toxicity test methods
Posted 2008-05-12
2008-09-01 implementation
Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China
Standardization Administration of China released
Foreword
This standard is identical with the Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 411 (1981), "sub-chronic dermal toxicity
Test Method "(in English).
The editorial changes made the following standards.
--- Increasing the scope;
--- A unit of measurement unity to our legal units of measurement;
--- Delete the reference section of the OECD.
This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points.
This standard is drafted by. China Center for Disease Control and Prevention of Occupational Health and Poison Control.
Participated in the drafting of this standard. Hubei CIQ.
The main drafters of this standard. Ai Wei Wu, Cui Hairong, star Guo, Guo Jian, Cheng Ye, Chen Jianjun, Zhao Hui.
Chemicals subchronic dermal toxicity test methods
1 Scope
This standard specifies the scope of rodent subchronic dermal toxicity test, the terms and definitions, basic test principle, test methods, test
Data and reports.
This standard applies to detect chemicals sub-chronic dermal toxicity test. Preliminary toxicity test data was obtained by the acute toxicity test
Thereafter, sub-chronic dermal toxicity determined to provide a predetermined trial period through the skin caused by repeated exposure to a potential health hazard
data.
2 Terms and definitions
The following terms and definitions apply to this standard.
2.1
(Period does not exceed 10% of animal life) during a portion of the test animals in the daily life of the animal through the skin by repeated exposure
Detrimental effects caused.
2.2
Percutaneous test, the amount of test substance is applied daily to the skin. Dose may be mass (g, mg) in the test animals or the weight of the coated units
The quality of the test substance (mg/kg) expressed.
2.3
(NAEL)
Test is the maximum dose was not observed (not visible) harmful effects. In experimental animal unit of body weight per day the amount of test substance
[Mg/(kg · d)] to represent.
2.4
Repeated exposure is long-term effects on sensitive group, or the concentration of the test substance or its metabolites deleterious effects due to the increase in the sensitive group.
3 test basic principles
The test substance at different doses per day, respectively, a gradient applied to each group of animals exposed skin, a set of one dose, continuous 90d. dye
During toxicity was observed signs of toxicity in animals every day. During the test of death and end of the test surviving animals to be sacrificed substantially Solutions
Sectional, histopathological examination as needed.
Test Method 4
4.1 test sample
4.1.1 The test substance is a solid or liquid;
4.1.2 test substance chemical identifying characteristics;
4.1.3 Purity test substance (type and content of impurities);
4.1.4 dissolution characteristics;
4.1.5 pH value (capable of measuring time);
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