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GB/T 21606-2022: Chemicals - Test method of acute dermal toxicity
Status: Valid GB/T 21606: Evolution and historical versions
| Standard ID | Contents [version] | USD | STEP2 | [PDF] delivered in | Standard Title (Description) | Status | PDF |
| GB/T 21606-2022 | English | 289 |
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Chemicals - Test method of acute dermal toxicity
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GB/T 21606-2022
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| GB/T 21606-2008 | English | 879 |
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Test method of acute dermal toxicity for chemicals
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GB/T 21606-2008
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PDF similar to GB/T 21606-2022
Basic data | Standard ID | GB/T 21606-2022 (GB/T21606-2022) | | Description (Translated English) | Chemicals - Test method of acute dermal toxicity | | Sector / Industry | National Standard (Recommended) | | Classification of Chinese Standard | A80 | | Word Count Estimation | 14,117 | | Issuing agency(ies) | State Administration for Market Regulation, China National Standardization Administration | GB/T 21606-2008: Test method of acute dermal toxicity for chemicals---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Test method of acute dermal toxicity for chemicals
ICS 13.300; 11.100
A80
National Standards of People's Republic of China
Chemicals acute dermal toxicity test methods
Posted 2008-04-01
2008-09-01 implementation
Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China
Standardization Administration of China released
Foreword
This revised standard adopts the United Nations Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 402 "Acute dermal toxicity test
Test "(1992.7) (in English).
This standard OECD Chemicals Test Method No. 402 compared with the following differences.
--- To OECD Chemicals Test Method No. 402 were editorial changes;
--- Increased the preamble;
--- Added Appendix section.
The Standard Appendix B, Appendix D normative appendix; Appendix A, Appendix C is informative appendix.
This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points.
This standard is drafted by. China Center for Disease Control and Prevention of Occupational Health and Poison Control.
Participated in the drafting of this standard. Tianjin Inspection and Quarantine Institute of Science and Technology, Henan Province Occupational Disease Prevention Hospital.
The main drafters of this standard. Ai Wei Wu, Chao-lin, HOU powder Xia Lin Zheng, Sun Jinxiu, LI Shuang, Zhang Yuan, in Chi Rui, Lining Tao, Tao.
Chemicals acute dermal toxicity test methods
1 Scope
This standard specifies the test object, test the basic principles, test methods, evaluation of the test results, the test animals reported acute dermal toxicity test
Reporting and interpretation of results.
This standard applies to the evaluation of acute dermal toxicity of chemicals.
2 Terms and definitions
2.1
Test samples once or several times within 24h after the health effects of skin damage arising from exposure.
2.2
Once or several times within 24h dermal exposure test sample, the test animals caused by the occurrence probability of death of 50% of the dose, in a unit body
Re-acceptance of the quality of the test sample [mg/kg or g/kg] to represent.
2.3
Chemical poisons represent the relationship between the dose of a particular group in the incidence of mass effect.
3 test purposes
Determining whether the test sample is absorbed through the skin and short-term percutaneous exposure arising from acute toxicity and strength, and to determine the subacute (slowly)
Percutaneous dose toxicity and other tests designed to provide experimental basis.
4 Test the basic principles
Before the test, the first test site to remove the animal's coat. The experimental animals were divided into several dose groups receiving different doses applied
Test samples, and then observed in experimental animals toxic reactions and death, calculated LD50. The test animals died in the gross anatomy and pathology
Histological examination of the surviving animals at the end of the test should also be done gross anatomy. Note that the test sample excluded due to local skin irritation or rot
Erosion effects caused by systemic effects.
5 Test methods
5.1 test sample
Insoluble or poorly soluble or particulate solid test sample to be milled through 100 mesh screen. With the amount of non-toxic and non-irritating excipient mix, in order to maintain
Contacting the sample with a test certificate good skin. Commonly used excipients are water, vegetable oils, vaseline, lanolin and the like. Liquid test sample is generally not
Will be diluted, it can be directly used dope test.
5.2 Experimental Animals
Preferred rats, rabbits or guinea pigs can also be used. Experimental animals were weight range requirements. rat 200g ~ 300g, guinea pigs 350g ~
450g, rabbits 2000g ~ 3000g.
During the test, in order to avoid scratching each other experimental animals, should be adopted in a single cage feeding.
Before the test, 24h, in the back of the animal to the hair on both sides of the midline, carefully check the skin, requiring intact, so as not to alter the permeability of the skin.
To the gross area of \u200b\u200bnot less than 10% of the body surface area of \u200b\u200bexperimental animals. Values \u200b\u200band calculation methods of various types of animals, body surface area, see Appendix D.
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