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GB/T 21604-2022: Chemicals - Test method of acute dermal irritation/corrosion
Status: Valid GB/T 21604: Evolution and historical versions
| Standard ID | Contents [version] | USD | STEP2 | [PDF] delivered in | Standard Title (Description) | Status | PDF |
| GB/T 21604-2022 | English | 189 |
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Chemicals - Test method of acute dermal irritation/corrosion
| Valid |
GB/T 21604-2022
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| GB/T 21604-2008 | English | 239 |
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Chemicals -- Test method of acute dermal irritation/corrosion
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GB/T 21604-2008
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PDF similar to GB/T 21604-2022
Basic data | Standard ID | GB/T 21604-2022 (GB/T21604-2022) | | Description (Translated English) | Chemicals - Test method of acute dermal irritation/corrosion | | Sector / Industry | National Standard (Recommended) | | Classification of Chinese Standard | A80 | | Word Count Estimation | 9,953 | | Issuing agency(ies) | State Administration for Market Regulation, China National Standardization Administration | GB/T 21604-2008: Chemicals -- Test method of acute dermal irritation/corrosion---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Chemicals. Test method of acute dermal irritation/corrosion
ICS 13.300; 11.100
A80
National Standards of People's Republic of China
Chemicals acute dermal irritation/corrosion test methods
Posted 2008-04-01
2008-09-01 implementation
Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China
Standardization Administration of China released
Foreword
This revised standard adopts the United Nations Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 404 "Acute dermal irritation /
Corrosive experiment "(1992.7) (in English).
This standard OECD Chemicals Test Method No. 404 compared with the following differences.
--- To OECD Chemicals Test Method No. 404 were editorial changes;
--- Increase the preamble.
This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points.
This standard is drafted by. Tianjin Inspection and Quarantine Institute of Science and Technology.
Participated in the drafting of this standard. Tianjin Inspection and Quarantine Institute of Science and Technology, Jiangnan University, China Chemical standardization, Tianjin Entry
Inspection and Quarantine Bureau, Chinese Center for Disease Prevention and Control of Occupational Health and Poison Control.
The main drafters. Zhang Yuan, Wangli Bing, Zhao Zhuo, Xu came, Wang Xiaobing, in Chi Rui, Li Chaoyang.
This standard was first formulated.
Chemicals acute dermal irritation/corrosion test methods
1 Scope
This standard specifies the animal chemicals acute dermal irritation/corrosion test terms and definitions, test methods and test results.
This standard applies to the determination of the acute skin irritation corrosive chemicals.
2 Normative references
The following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent
Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research
Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard.
GB 14924.4 rabbit animal feed
GB 14925 Laboratory Animal Facilities and Environment
3 Terms and Definitions
The following terms and definitions apply to this standard.
3.1
Skin after application of the test sample local produce irreversible damage.
3.2
Reversible inflammatory changes in the skin after application of the test sample was produced locally.
Test Method 4
4.1 test animals
4.1.1 animal strains
Preferred healthy adult white rabbits.
4.1.2 Number and sex
Selection of male and/or female animals, using at least four, such as certain suspicious reaction, we need to increase the number of test animals.
4.1.3 Feeding Conditions
Feeding conditions should be consistent with GB 14924.4, GB 14925's requirements. Test animals should be caged. Experimental animal room temperature, rabbit
Of 20 ℃ ± 3 ℃, relative humidity of 30% to 70%. When using artificial light should be kept light 12h, dark 12h. Conventional test selection
Laboratory feed, water should be sufficient, without restriction.
4.1.4 Prepare animals
Test animals should be reared under quarantine conditions and adapt to the environment at least 5d. Before testing within 24h, carefully cut close to the skin test
Coat both sides of the spine back of the animal, pay attention to not damage the skin. Range to hair, each about 3cm × each 3cm. Lossless healthy skin area
experimenting.
4.2 test substance
4.2.1 If the test substance is a liquid, usually not diluted. It can be used directly exposed to liquid.
4.2.2 If the test substance is a solid, it should be pulverized with water or other suitable media dissolving or wetting, to ensure that the test substance with skin.
Good contact. If you use other media other than water, it should take into account the impact of the media on the subject matter of skin irritation.
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