GB/T 24781-2009 English PDFUS$169.00 · In stock
Delivery: <= 3 days. True-PDF full-copy in English will be manually translated and delivered via email. GB/T 24781-2009: Guidance on the validation of (Q) SAR models for chemicals properties -- Ecological effects Status: Valid
Basic dataStandard ID: GB/T 24781-2009 (GB/T24781-2009)Description (Translated English): Guidance on the validation of (Q) SAR models for chemicals properties -- Ecological effects Sector / Industry: National Standard (Recommended) Classification of Chinese Standard: A80 Classification of International Standard: 13.300 Word Count Estimation: 7,724 Date of Issue: 2009-12-15 Date of Implementation: 2010-07-01 Regulation (derived from): Announcement of Newly Approved National Standards No. 15 of 2009 (total 155) Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China Summary: This standard specifies the eco- toxicological properties of chemicals SAR models validation guidelines. This standard applies to existing and future development of the various (Q) SAR models. GB/T 24781-2009: Guidance on the validation of (Q) SAR models for chemicals properties -- Ecological effects---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order. Guidance on the validation of (Q) SAR models for chemicals properties. Ecological effects ICS 13.300 A80 National Standards of People's Republic of China Validation Guidance chemical properties (Q) SAR model Ecotoxicological properties Posted 2009-12-15 2010-07-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released ForewordThe standard reference uses Organisation for Economic Co-operation and Development (OECD) Guidelines document ENV/JM/MONO (2007) 2 "(quantitative) structure - Verification activity relationships [(Q) SAR] model guidance document "(in English), which related to the technical content of the above documents exactly. Appendix A of this standard is an informative annex. This standard by the National Standardization Technical Committee chemicals management and centralized dangerous. This standard is drafted by. AQSIQ's import and export of chemical safety research center. Participated in the drafting of this Standard. China Inspection and Quarantine Science Research Institute, Hubei Exit Inspection and Quarantine, the Chemical Institute of Standardization, Jiangxi CIQ. The main drafters of this standard. Cheng Yan, Falls Apart, Lee , Songnai Ning, Zhou Xin, Cui Hairong, Guo Jian. This standard is the first release.IntroductionEU on June 1, 2007 through legislation "chemicals Registration, Evaluation, Authorization and Restriction" (hereinafter referred to as the REACH Regulation), and in 2008 June 1 formally implemented. After the implementation of the regulation of chemicals entering the EU market for unified management. I State response to the EU REACH regulations, developed a series of chemical safety standards equivalent to the relevant technical transformation of the EU REACH Regulation content. EU REACH Regulation and the United Nations' Globally Harmonized System of Classification and Labeling "(GHS) in order to reduce animal testing, clearly stipulates Given the forecast (Q) SAR model prediction method can be used in certain circumstances the chemical properties. This standard is in response to the EU REACH regulations on the use of technical indicators reference to OECD Guidance Document ENV/JM / MONO (2007) 2 "(Quantitative) Structure - Activity Relationships [(Q) SAR] validated the model guidance document" (in English) and REACH Technology Law Regulation EUR21866EN2005 "(quantitative) structure - activity relationship characteristics. initial guidance" (in English), and their relevant technical content Exactly these documents, the establishment of a verification guide chemicals ecotoxicological properties (Q) SAR model. Validation Guidance chemical properties (Q) SAR model Ecotoxicological properties1 ScopeThis standard specifies the verification guidelines chemical toxicological properties (Q) SAR model. This standard applies to existing as well as a variety of (Q) SAR model developed in the future.2 Terms and definitionsThe following terms and definitions apply to this standard. 2.1 Material effects and molecular descriptors (quantitative) the relationship between the characters. 2.2 End basis and scope of application (Q) SAR described for (Q) SAR model operation of conformity, fit and forecasting capabilities, as well as machine Reliability and relevance of the evaluation process made interpretation.3 Principles for the Validation3.1 determine the end point. 3.2 explicit calculation algorithm. 3.3 determine the range of applications. 3.4 Evaluation meets the appropriate degree, applicable and predictive capabilities. 3.5 If possible, provide a mechanism to explain.4 Verify the principles set forth4.1 determine the end point 4.1.1 Different (Q) SAR prediction module for different endpoints. (Q) SAR model eco-toxicological properties of chemicals in use Prediction, common end point ecotoxicological parameters, including median lethal concentration (LC50), half effect concentration (EC50), the lowest observed effect Should concentration (LOEC), no observed effect concentration (NOEC), biological oxygen demand (BOD), chemical oxygen demand (COD), hydrolysis, biodegradation Solutions for bioconcentration factor (BCF), n-octanol/water partition coefficient (Kow), the absorption rate constant, elimination rate constant, partition coefficient, adsorption system And number. 4.1.2 When using (Q) SAR model eco-toxicological properties of chemicals to predict commonly used descriptor includes n-octanol/water partition coefficient Number (Kow of), water solubility, degradation constant, hydrogen bonding and molecular surface area. 4.1.3 a definite end at least the following factors. a) generating a set of detailed information modeling data; Different b) the test program will not result in significantly different end values; Different c) test solutions internal factors do not lead to different results; d) (Q) range of chemicals SAR prediction object is contained within the target range of chemicals test solutions; e) end (Q) SAR prediction of the end of the test program of the same; ......Tips & Frequently Asked Questions:Question 1: How long will the true-PDF of GB/T 24781-2009_English be delivered?Answer: Upon your order, we will start to translate GB/T 24781-2009_English as soon as possible, and keep you informed of the progress. 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