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Test method of in vivo mammalian bone marrow chromosome aberration for dangerous goods
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Basic data
| Standard ID | SN/T 2177-2008 (SN/T2177-2008) |
| Description (Translated English) | Test method of in vivo mammalian bone marrow chromosome aberration for dangerous goods |
| Sector / Industry | Commodity Inspection Standard (Recommended) |
| Classification of Chinese Standard | C70 |
| Classification of International Standard | 13.300 |
| Word Count Estimation | 6,672 |
| Date of Issue | 2008-09-04 |
| Date of Implementation | 2009-03-16 |
| Quoted Standard | GB 14924.1; GB 14925 |
| Adopted Standard | OECD NO.475-1997, MOD |
| Issuing agency(ies) | General Administration of Customs |
| Summary | This standard specifies the in vivo mammalian bone marrow chromosome aberration test terminology and definitions, reagents and instruments, test methods, test results and evaluation of results. This standard is applicable to the detection of chemicals on the mutagenicity of bone marrow cells. |
SN/T 2177-2008: Test method of in vivo mammalian bone marrow chromosome aberration for dangerous goods
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Test method of in vivo mammalian bone marrow chromosome aberration for dangerous goods
Exit inspection and quarantine industry standard book People's Republic of China
DG mammalian bone marrow cells
Chromosome aberration test methods
Posted 2008-09-04
2009-03-16 implementation
People's Republic of China
The State Administration of Quality Supervision, Inspection and Quarantine released
Foreword
This revised standard adopts the United Nations Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 475 "mammalian bone marrow staining
Aberrations Test "(1997).
This standard OECD Chemicals Test Method No. 475 compared with the following differences.
--- To OECD Chemicals Test Method No. 475 were editorial changes;
--- Increased the preamble;
--- Increased the definitions section;
--- Deleted part of the test report.
This standard was proposed by the State Administration of Quality Supervision Inspection and Quarantine of People's Republic of China.
This standard by the National Certification and Accreditation Administration Committee.
This standard is drafted by. People's Republic of China Tianjin Exit Inspection and Quarantine.
Participated in the drafting of this standard. the Chemical Institute of Standardization.
The main drafters. Zhang Yuan Zhao good Lippo, in Rui Zhi, Zhao Zhuo, Xiongzhong Jiang, Li Xue Yang.
This standard is the first release of the entry-exit inspection and quarantine industry standards.
DG mammalian bone marrow cells
Chromosome aberration test methods
1 Scope
This standard specifies the in vivo mammalian bone marrow chromosome aberration test terms and definitions, reagents and instruments, test methods, test results
And the results of the evaluation.
This standard is applicable to the detection of mutagenicity of chemicals on bone marrow cells.
2 Normative references
The following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent
Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research
Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard.
GB 14924.1 animal feed common quality standards
GB 14925 Laboratory Animal Facilities and Environment
The Ministry of Health "disinfection technical specifications"
3 Terms and Definitions
The following terms and definitions apply to this standard.
3.1
Structural chromosome damage, manifested as chromatid breaks or chromatid recombination fracture injury.
3.2
Chromosome structural damage, the performance of the two chromatids of the same sites are broken or appear to change the broken reorganization.
3.3
After the S phase of DNA replication, mitosis starts another S phase nuclei process was not performed. As a result, chromosome
There 4,8,16 times chromatin.
3.4
The length of the chromosome or chromatid damage is less than the width of a chromatid, arranged in the smallest error chromatids.
3.5
Chromosome number changes, unlike normal karyotype.
3.6
Normal diploid number of chromosomes in mammals, under the action of chemical mutagens, the number of triploid chromosome multiplied into four
Times and the like.
...
