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SN/T 2168-2008: Test method of reproduction toxicity for dangerous goods
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SN/T 2168-2008: Test method of reproduction toxicity for dangerous goods

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Test method of reproduction toxicity for dangerous goods Exit inspection and quarantine industry standard book People's Republic of China Reproductive toxicity testing of dangerous goods Posted 2008-09-04 2009-03-16 implementation People's Republic of China The State Administration of Quality Supervision, Inspection and Quarantine released

Foreword

This revised standard adopts the United Nations Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 415 "generation reproduction toxicity test Test "(1983), No. 416 "two-generation reproduction toxicity test" (2001). This standard OECD Chemicals Test Method No. 415, No. 416 compared with the following differences. --- To OECD Chemicals Test Method No. 415, No. 416 were editorial changes; --- Increase the preamble. This standard was proposed by the State Administration of Quality Supervision Inspection and Quarantine of People's Republic of China. This standard by the National Certification and Accreditation Administration Committee. This standard is drafted by. People's Republic of China Tianjin Exit Inspection and Quarantine. Participated in the drafting of this standard. the Chemical Institute of Standardization, Jiangnan University, Tianjin Academy of Inspection and Quarantine Science and Technology. The main drafters of this standard. Lining Tao, Zhang Yuan, Lei Zhou, Zhi Rui in, Xiongzhong Jiang, Zhao Lihua. This standard is the first release of the entry-exit inspection and quarantine industry standards. Reproductive toxicity testing of dangerous goods

1 Scope

This standard specifies the test methods and test results of dangerous chemicals genotoxicity tests. This standard applies to the determination of reproductive toxicity of hazardous chemicals.

2 Normative references

The following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard. GB 14924.1 animal feed common quality standards GB 14925 Laboratory Animal Facilities and Environment

3 Terms and Definitions

The following terms and definitions apply to this standard. 3.1 Human and mammalian reproduction complex physiological process race, including the occurrence of gender germ cells or gametes, said the release of gametes, sexual Week Period and sex, fertilized egg, zygote cleavage, blastocyst formation, implantation, embryogenesis, embryonic development, organogenesis, fetal development, points Childbirth and lactation, postnatal development until sexual maturity and breeding the next generation of process. 3.2 The adverse effects of toxic chemicals on the reproductive system, including both parents and damage to the embryo, newborns. Test Method 4 4.1 Test equipment and reagents 4.1.1 Equipment Gavage needles, syringes and needles, surgical scissors, scalpels, tweezers toothless, electronic scales, animal scales. 4.1.2 Reagents Distilled water, saline or a solvent such as dimethyl sulfoxide. 4.2 test animals Selection of rats, each dose group of at least 20 female, 10 male. Experimental animal breeding conditions and should be consistent with GB 14924.1 GB 14925 relevant provisions. Dose group and 4.3 The experimental animals were randomly divided into at least two dose groups and a control. The highest dose should enable the parent animal toxicity anti-apparent It should, but does not cause the death of the animal; low dose should not induce any toxicity parental and offspring animals. If the toxicity of the test sample than Low, 1000mg/kg bw reproductive process have not been any side effects, you can use a limited test, that test does not need to set up Other dose group. If the high-dose pre-test to observe significant maternal toxicity, but had no effect on fertility, it can also be used a limited test. ...