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RB/T 061-2021: Technical specifications on euthanasia of laboratory animals
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RB/T 061-2021: Technical specifications on euthanasia of laboratory animals

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Technical specifications on euthanasia of laboratory animals ICS 03.120.20 CCSA00 People's Republic of China Certification and Accreditation Industry Standards Technical Specifications for Euthanasia of Laboratory Animals Published on 2021-11-04 2022-01-01 Implementation Released by the National Certification and Accreditation Administration of the People's Republic of China

foreword

This document is in accordance with the provisions of GB/T 1.1-2020 "Guidelines for Standardization Work Part 1.Structure and Drafting Rules of Standardization Documents" drafted. Please note that some content of this document may be patented. Publication of this document Institutions do not assume responsibility for identifying patents. This document is proposed and managed by the National Certification and Accreditation Administration. This document was drafted by. China National Accreditation Center for Conformity Assessment, Chinese Center for Disease Control and Prevention, Kunming Animal Research, Chinese Academy of Sciences Institute, Shanghai Laboratory Animal Research Center, Peking University, Institute of Laboratory Animal Research, Chinese Academy of Medical Sciences, Soochow University, China Food and Drug Control Research Institute, Beijing Laboratory Animal Management Office, Guangdong Laboratory Animal Monitoring Institute, Shandong University, Institute of Zoology, Chinese Academy of Sciences, China Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Academy of Sciences, Military Medical Research, Academy of Military Sciences of the Chinese People's Liberation Army Hospital, Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd., and Jiangsu Jicui Yaokang Biotechnology Co., Ltd. The main drafters of this document. Shi Guanghua, Liu Xiaoyu, Lu Longbao, Zhou Zhengyu, Li Na, Li Qin, Lu Xuancheng, Wei Xiaofeng, Wang Xile, Duo Shuguang, Li Yanqing, Shao Qiming, Zhang Xiaodi, Zhang Aiguo, Wu Baojin, Qiu Yefeng, Lu Shengming, Huang Ren, Gao Cheng. Technical Specifications for Euthanasia of Laboratory Animals

1 Scope

This document specifies the basic principles, resource allocation, process control and other management and technical requirements for the implementation of euthanasia for experimental animals. This document is applicable to the establishment and improvement of the technical capacity of euthanasia and the implementation of euthanasia in institutions that produce and use laboratory animals. Administration, also applies to accreditation bodies, regulatory bodies and clients implementing euthanasia in institutions producing and using laboratory animals (hereinafter referred to as "institutions") Confirmation of ability.

2 Normative references

The contents of the following documents constitute essential provisions of this document through normative references in the text. Among them, dated citations documents, only the version corresponding to that date applies to this document; for undated references, the latest edition (including all amendments) applies to this document. GB/T 27416-2014 General requirements for the quality and competence of laboratory animal institutions RB/T 173-2018 Guidelines for the Review of Humane Endpoints in Laboratory Animals

3 Terms and Definitions

The following terms and definitions apply to this document. 3.1 animal experiment Any experiment using animals for acceptable purposes that may cause pain, distress, anxiety, lasting damage to the animals injury, pregnancy, childbirth, etc. [Source. GB/T 27416-2014, 3.1] 3.2 laboratory animalslaboratoryanimals Animals specially bred and raised to relevant standards and intended for experimental or other scientific purposes. [Source. GB/T 27416-2014, 3.2] 3.3 pain pain An unpleasant feeling and emotional feeling, often accompanied by actual or potential physical damage. [Source. RB/T 173-2018, 3.3] NOTE. Common types of pain include acute response pain—a painful response to a brief noxious stimulus without tissue damage, such as foot reflexes; Chronic Inflammatory Pain—A chronic pain that may be severe or distressing to the animal due to tissue damage and inflammatory processes, such as Local infection; neuropathic pain - pain response due to functional impairment or abnormal activation of the peripheral or central nervous system, often severe and Causes severe pain to animals, such as visceral tumors compressing nerves. 3.4 painful distress An undesirable state in which an animal exhibits physical and behavioral changes due to maladaptation or inability to adapt to stress. Note 1.Situations that cause animals to experience significant pain, fear and anxiety are the main stressors that cause animal distress. ...