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GB/T 32121-2015: Determination of 4-(aminomethyl) cyclohexanecarboxylic acid (tranexamic acid) in toothpaste -- HPLC-MS/MS
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GB/T 32121-2015	English	169	Add to Cart	3 days [Need to translate]	Determination of 4-(aminomethyl) cyclohexanecarboxylic acid (tranexamic acid) in toothpaste -- HPLC-MS/MS

GB/T 32121-2015: Determination of 4-(aminomethyl) cyclohexanecarboxylic acid (tranexamic acid) in toothpaste -- HPLC-MS/MS

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Determination of 4- (aminomethyl) cyclohexanecarboxylic acidtranexamic acid) in toothpaste - HPLC-MS/MS ICS 71.100.40 Y43 National Standards of People's Republic of China Toothpaste 4-amino-methyl cyclohexane carboxylic acid (tranexamic acid) of High performance liquid chromatography tandem mass spectrometry Determinationof4- (aminomethyl) cyclohexanecarboxylicacid (Tranexamicacid) intoothpaste-HPLC-MS/MS Issued on. 2015-10-09 2016-05-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released

Foreword

This standard was drafted in accordance with GB/T 1.1-2009 given rules. Please note that some of the content of this document may involve patents. Release mechanism of the present document does not assume responsibility for the identification of these patents. The standard proposed by China National Light Industry Council. The standard oral care products by the National Technical Committee of Standardization Technical Committee toothpaste (SAC/TC492/SC1) centralized. This standard was drafted. Dalian City Product Quality Supervision, Inspection (National Day of Product Quality Supervision and Inspection Center), Dalian Standard Testing Technology Art research center. The main drafters of this standard. Maoxi Qin, Zheng Shunli Hu Xia, Ren Guojie, Li Chunling, Dongguang Bin. Toothpaste 4-amino-methyl cyclohexane carboxylic acid (tranexamic acid) of High performance liquid chromatography tandem mass spectrometry

1 Scope

This standard specifies the toothpaste of 4-aminomethyl cyclohexane carboxylic acid (tranexamic acid) was determined by high performance liquid chromatography tandem mass spectrometry This standard applies to the determination of toothpaste 4-amino-methyl cyclohexane carboxylic acid (tranexamic acid) is. The standard method detection limit. 0.3μg/g; lower limit of quantification. 1.0μg/g.

2 Normative references

The following documents for the application of this document is essential. For dated references, only the dated version suitable for use herein Member. For undated references, the latest edition (including any amendments) applies to this document. GB/T 6379.1 measurement methods and results of Accuracy (trueness and precision) - Part 1. General principles and definitions GB/T 6379.2 measurement methods and results of Accuracy (trueness and precision) - Part 2. Determine the standard measurement method to repeat Of the basic methods of reproduction Laboratory use specifications and test methods GB/T 6682 Analysis Method 3 points Toothpaste first dispersed aqueous solution, methylene chloride was then added, vortexed and centrifuged to remove most of the solids of a surfactant, the supernatant And 3% aqueous formic acid under acidic conditions after mixing too strong cation solid-phase extraction column, 1.5% aqueous formic acid leaching bed, 20% aqueous methanol Solution (containing 2% aqueous ammonia) to give the object eluent after 3% formic acid aqueous solution and set the volume, separated by a liquid chromatography tandem mass spectrometry measurement Set the standard curve external standard. Phase extraction process because the target was unstable at low concentrations, extraction and solid required to EDTA (EDTA) disodium as a stabilizer for protection.

4 standard materials and reagents

Unless otherwise specified, the reagents were of analytical grade water to comply with GB/T 6682 with a water laboratory. 4.1 Standards Table 1 Standard Substance Information Title compound 4-amino-methyl-cyclohexanecarboxylic acid English name of 4- (aminomethyl) cyclohexanecarboxylicacid, tranexamicacid Alias \u200b\u200btranexamic acid, tranexamic acid, tranexamic acid CAS No. 1197-18-8 Formula C8H15NO2 ...