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Tissue engineering medical device products - Generic requirement for bio-derived peripheral nerve repair implant
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YY/T 1951-2024
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Basic data Standard ID | YY/T 1951-2024 (YY/T1951-2024) | Description (Translated English) | Tissue engineering medical device products - Generic requirement for bio-derived peripheral nerve repair implant | Sector / Industry | Medical Device & Pharmaceutical Industry Standard (Recommended) | Classification of Chinese Standard | C45 | Classification of International Standard | 11.040.40 | Word Count Estimation | 18,156 | Date of Issue | 2024-09-29 | Date of Implementation | 2025-10-15 | Issuing agency(ies) | State Drug Administration | Summary | This standard specifies the general requirements for performance indicators, packaging labels, storage, transportation, etc. of biogenic peripheral nerve implants for nerve repair, and specifies the corresponding test methods. This standard applies to biogenic peripheral nerve repair implants. This standard does not apply to non-biogenic peripheral nerve implants. |
YY/T 1951-2024: Tissue engineering medical device products - Generic requirement for bio-derived peripheral nerve repair implant ---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
ICS 11.040.40
CCSC45
Pharmaceutical Industry Standards of the People's Republic of China
Biogenicity of Tissue Engineering Medical Devices
General requirements for peripheral nerve repair implants
Released on 2024-09-29
Implementation on October 15, 2025
The State Drug Administration issued
Table of Contents
Preface III
1 Scope 1
2 Normative references 1
3 Terms and Definitions 2
4 Performance requirements 2
4.1 Composition and structure 2
4.2 Physical properties 2
4.3 Chemical properties 3
4.4 Biological properties 5
4.5 Biological evaluation 5
5 Inspection methods 6
5.1 Composition and structure 6
5.2 Physical properties 6
5.3 Chemical properties 7
5.4 Biological properties 8
5.5 Biological evaluation 9
6 Raw material safety requirements 9
6.1 Materials of animal origin 9
6.2 Allogeneic materials 9
7 Logo 9
7.1 Packaging Marking 9
7.2 Storage and transportation signs 10
8 Packaging, transportation and storage 10
Reference 11
Foreword
This document is in accordance with the provisions of GB/T 1.1-2020 "Guidelines for standardization work Part 1.Structure and drafting rules for standardization documents"
Drafting.
Please note that some of the contents of this document may involve patents. The issuing organization of this document does not assume the responsibility for identifying patents.
This document is proposed by the State Food and Drug Administration.
This document is organized by the National Technical Committee for Standardization of Surgical Implants and Orthopedic Devices, Technical Committee for Engineering Medical Device Products
(SAC/TC110/SC3) is responsible for this matter.
This document was drafted by. China Food and Drug Administration, Nantong University, the First Affiliated Hospital of Sun Yat-sen University, Nankai University,
People's Liberation Army General Hospital, Sichuan University, Tianjin Medical Device Quality Supervision and Inspection Center, Jiangsu Yitong Biotechnology Co., Ltd., Guangzhou Zhongda
Medical Devices Co., Ltd., Beijing Huifukang Medical Technology Co., Ltd., Shandong Junxiu Biotechnology Co., Ltd., Tianxinfu (Beijing) Medical
Medical Equipment Co., Ltd.
The main drafters of this document are. Shao Anliang, Xu Liming, Yang Yumin, Zhu Qingtang, Zhu Meifeng, Peng Jiang, Ao Qiang, Li Libin, Zhang Tian, Yang Yuexiong,
Cheng Huijing, Gao Xiuwei, Li Xiaojing, Zhao Danmei, Li Chongchong, Zhao Yahong, Zheng Canbin, Dong Xianhao, Wang Yu, Cheng Junqiu, Li Jia, Zhao Minjian, Zhang Yang,
Wang Chao, Ren Xiaomin, and Zhang Wei.
Biogenicity of Tissue Engineering Medical Devices
General requirements for peripheral nerve repair implants
1 Scope
This document specifies the performance indicators, packaging labels, storage, transportation, etc. of bioderived peripheral nerve implants used for peripheral nerve repair.
General requirements and corresponding test methods are described.
This document applies to bioderived peripheral nerve repair implants.
This document does not apply to peripheral nerve implants of non-biological origin.
Note. Peripheral nerve repair implants mainly include. peripheral nerve implants used to repair peripheral nerve defects of varying degrees;
Provide a nerve growth microenvironment for the spontaneous repair of damaged or ruptured peripheral nerves, and guide the selective growth (chemotaxis-induced) of nerve fibers
Nerve sleeve; peripheral nerve implant used to prevent local adhesion of peripheral nerve injury or prevent neuroma formation.
2 Normative references
The contents of the following documents constitute essential clauses of this document through normative references in this document.
For referenced documents without a date, only the version corresponding to that date applies to this document; for referenced documents without a date, the latest version (including all amendments) applies to
This document.
GB/T 191 Pictorial markings for packaging, storage and transportation
GB/T 14233.1 Inspection methods for medical infusion, blood transfusion and injection equipment Part 1.Chemical analysis methods
GB/T 16886.1 Biological evaluation of medical devices Part 1.Evaluation and testing in the risk management process
GB/T 16886.3 Biological evaluation of medical devices Part 3.Tests for genotoxicity, carcinogenicity and reproductive toxicity
GB/T 16886.5 Biological evaluation of medical devices Part 5.In vitro cytotoxicity test
GB/T 16886.6 Biological evaluation of medical devices Part 6.Local reaction test after implantation
GB/T 16886.7 Biological evaluation of medical devices Part 7.Ethylene oxide sterilization residues
GB/T 16886.10 Biological evaluation of medical devices Part 10.Irritation and skin sensitization tests
GB/T 16886.12 Biological evaluation of medical devices Part 12.Sample preparation and reference materials
GB/T 16886.20 Biological evaluation of medical devices Part 20.Principles and methods of immunotoxicology testing of medical devices
GB/T 36988 Guidelines for the operation of human tissues for tissue engineering
SN/T 2843 Determination of rubber content in raw silk
YY 0167 Non-absorbable surgical suture
YY/T 0313 Requirements for packaging of medical polymer products and information provided by manufacturers
YY/T 0513.1 Allogeneic repair materials Part 1.Basic requirements for tissue banks
YY/T 0771.1 Medical devices of animal origin Part 1.Application of risk management
YY/T 0771.2 Medical devices of animal origin Part 2.Control of sources, collection and disposal
YY/T 0771.3 Medical devices of animal origin Part 3.Removal and inactivation of viruses and transmissible spongiform encephalopathy (TSE) agents
confirm
YY/T 1453 Characterization method of type I collagen in tissue engineering medical devices
YY/T 1561 Detection of residual α-Gal antigen in animal-derived scaffold materials of tissue engineering medical devices
YY/T 1699 Chitosan for tissue engineering medical devices
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