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Determination of nonylphenol in cosmetics. Liquid chromatography tandem mass spectrometry
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SN/T 4146-2015
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Basic data | Standard ID | SN/T 4146-2015 (SN/T4146-2015) | | Description (Translated English) | Determination of nonylphenol in cosmetics. Liquid chromatography tandem mass spectrometry | | Sector / Industry | Commodity Inspection Standard (Recommended) | | Classification of Chinese Standard | Y42 | | Classification of International Standard | 71.100.70 | | Word Count Estimation | 8,890 | | Date of Issue | 2015-02-09 | | Date of Implementation | 2015-09-01 | | Quoted Standard | GB/T 6682 | | Regulation (derived from) | State-Quality-Inspection-Accreditation [2015] 59 | | Issuing agency(ies) | General Administration of Customs | | Summary | This standard specifies the cosmetics nonylphenol liquid chromatography - mass spectrometry/mass spectrometry. This standard applies to the determination of creams, loose powder, liquid, lipstick Cosmetics nonylphenol. | SN/T 4146-2015: Determination of nonylphenol in cosmetics. Liquid chromatography tandem mass spectrometry
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Determination of nonylphenol in cosmetics.Liquid chromatography tandem mass spectrometry
People's Republic of China Entry-Exit Inspection and Quarantine Industry Standard
Determination of nonylphenol in cosmetics
Liquid chromatography-mass spectrometry/mass spectrometry
Released on.2015-02-09
2015-09-01 implementation
People's Republic
The General Administration of Quality Supervision, Inspection and Quarantine issued
Foreword
This standard was drafted in accordance with the rules given in GB/T 1.1-2009.
Please note that some of the contents of this document may involve patents. Publication of this document
The organization is not responsible for identifying these patents.
This standard is proposed and managed by the National Certification and Accreditation Administration.
This standard was drafted. China Academy of Inspection and Quarantine, Jiangsu Entry-Exit Inspection and Quarantine Bureau of the People's Republic of China, the Chinese people
Heguo Zhejiang Entry-Exit Inspection and Quarantine Bureau.
The main drafters of this standard. Ma Qiang, Bai Hua, Li Wentao, Wang Chao, Yang Tianyu, Xie Wen.
Determination of nonylphenol in cosmetics
Liquid chromatography-mass spectrometry/mass spectrometry
1 Scope
This standard specifies the liquid chromatography-mass spectrometry/mass spectrometry method for the determination of nonylphenol in cosmetics.
This standard applies to the determination of nonylphenol in creams, loose powders, liquids, and lipstick cosmetics.
2 Normative references
The following documents are indispensable for the application of this document. For dated references, only dated versions apply to this article.
Pieces. For undated references, the latest edition (including all amendments) applies to this document.
GB/T 6682 Analytical laboratory water specifications and test methods
3 Method summary
Different types of cosmetic samples were ultrasonically extracted with methanol and dichloromethane or a mixture of absolute ethanol and dichloromethane.
The liquid was purified by centrifugation and solid phase extraction, and then determined by liquid chromatography-mass spectrometry/mass spectrometry and quantified by internal standard method.
4 reagents and materials
Unless otherwise stated, the reagents used were of analytical grade and the water was the first grade water specified in GB/T 6682.
4.1 Methanol. LC-MS grade.
4.2 Nonylphenol standard substance. CAS84852-15-3, purity 98% or more.
4.3 4-n-nonylphenol standard substance. CAS104-40-5, purity 98% or more.
4.4 Nonylphenol standard stock solution. Accurately weigh the appropriate amount of nonylphenol standard substance (accurate to 0.1mg), and prepare the concentration in methanol.
The 100 mg/L standard stock solution is stored at 4 ° C in the dark and is valid for 3 months.
4.5 4-n-nonylphenol internal standard working solution. accurately weigh the appropriate amount of 4-n-nonylphenol standard substance (accurate to 0.1mg), prepared with methanol
The internal standard working solution with a concentration of 10 mg/L was stored at 4 ° C in the dark and was valid for 3 months.
4.6 Microporous membrane. 0.45μm, PTFE.
4.7 Solid phase extraction column. The filler is N-vinylpyrrolidone-divinylaniline,.200 mg, 6 mL, or equivalent. Use before use
Activated with 6 mL of methanol and 6 mL of water.
5 Instruments and equipment
5.1 Liquid Chromatography-Series Quadrupole Mass Spectrometer. equipped with an electrospray ion source.
5.2 Ultrasonic water bath.
5.3 Analytical balance. Sensitivity is 0.0001g and 0.001g.
5.4 Centrifuge. The speed is not less than 5000r/min.
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