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GBZ39502-2020: Laboratory animal - Guideline of COVID-19 animal models preparation
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| GB/Z 39502-2020 | English | 119 |
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Laboratory animal - Guideline of COVID-19 animal models preparation
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GB/Z 39502-2020
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Basic data | Standard ID | GB/Z 39502-2020 (GB/Z39502-2020) | | Description (Translated English) | Laboratory animal - Guideline of COVID-19 animal models preparation | | Sector / Industry | National Standard | | Classification of Chinese Standard | B44 | | Classification of International Standard | 65.020.30 | | Word Count Estimation | 6,653 | | Date of Issue | 2020-11-19 | | Date of Implementation | 2021-06-01 | | Regulation (derived from) | National Standard Announcement No. 26 of 2020 | | Issuing agency(ies) | State Administration for Market Regulation, China National Standardization Administration | GBZ39502-2020: Laboratory animal - Guideline of COVID-19 animal models preparation---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
GB /Z 39502-2020
Laboratory animal-Guideline of COVID-19 animal models preparation
ICS 65.020.30
B44
National Standardization Guiding Technical Documents of the People's Republic of China
Experimental animal novel coronavirus pneumonia
(COVID-19) Animal Model Preparation Guide
2020-11-19 released
2021-06-01 implementation
State Administration for Market Regulation
Issued by the National Standardization Management Committee
Foreword
This guiding technical document was drafted in accordance with the rules given in GB/T 1.1-2009.
This guiding technical document was proposed and managed by the National Laboratory Animal Standardization Technical Committee (SAC/TC281).
Drafting units of this guiding technical document. Institute of Medical Laboratory Animals, Chinese Academy of Medical Sciences, Wuhan Institute of Virology, Chinese Academy of Sciences,
Institute of Medical Biology, Chinese Academy of Medical Sciences, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences.
The main drafters of this guiding technical document. Qin Chuan, Wei Qiang, Yuan Zhiming, Peng Xiaozhong, Bu Zhigao, Bao Linlin, Gao Hong, Deng Wei, Liu Jiangning,
Kong Qi.
Experimental animal novel coronavirus pneumonia
(COVID-19) Animal Model Preparation Guide
Important note. The animal model preparation and experimental process in this document require exposure to the new coronavirus, and operators should control the infection risk based on the risk assessment.
1 Scope
This technical guidance document provides guidance on the preparation principles, preparation methods and evaluation indicators of animal models of novel coronavirus pneumonia (COVID-19).
This technical guidance document is applicable to the preparation and evaluation of animal models of novel coronavirus pneumonia (COVID-19).
2 Normative references
The following documents are indispensable for the application of this document. For dated reference documents, only the dated version applies to this document.
For undated references, the latest version (including all amendments) applies to this document.
GB 14925-2010 Laboratory Animal Environment and Facilities
GB 19489-2008 General requirements for laboratory biosafety
GB/T 35892 Guidelines for Ethical Review of Laboratory Animal Welfare
3 Terms and definitions
The following terms and definitions apply to this document.
3.1
Novel Coronavirus Pneumonia (COVID-19) Animal Model
Artificially infect animals with the new coronavirus (SARS-CoV-2) strain, so that it can simulate the clinical manifestations and onset of COVID-19
Disease animals with characteristics such as process, pathophysiological changes, immunological response, etc.
4 Preparation principles
4.1 Choose susceptible animals
It should be based on the animal's breed, genetic classification, microbiological grade, and sensitivity to the new coronavirus (SARS-CoV-2), etc.
Choose experimental animals.
4.2 Selection of representative pathogens
According to the clinical epidemiological data of human COVID-19 and the experimental purpose of the animal model, select the relevant pathogenic representative strains and fill them.
Consider the active state of the pathogen.
4.3 Maximizing disease reproduction
When preparing the COVID-19 animal model, it simulates the clinical manifestations, disease process, and pathophysiology of human COVID-19 disease to the greatest extent
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