GB/T 21754: Evolution and historical versions
| Standard ID | Contents [version] | USD | STEP2 | [PDF] delivered in | Standard Title (Description) | Status | PDF |
| GB/T 21754-2025 | English | RFQ |
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3 days [Need to translate]
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Chemicals - Test method of 28 day (subacute) inhalation toxicity
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GB/T 21754-2025
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| GB/T 21754-2008 | English | 279 |
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3 days [Need to translate]
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Chemicals -- Test method of repeated dose inhalation toxicity: 28/14-day study
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GB/T 21754-2008
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Basic data | Standard ID | GB/T 21754-2025 (GB/T21754-2025) | | Description (Translated English) | Chemicals - Test method of 28 day (subacute) inhalation toxicity | | Sector / Industry | National Standard (Recommended) | | Date of Implementation | 2025-12-01 | | Older Standard (superseded by this standard) | GB/T 21754-2008 | GB/T 21754-2008: Chemicals -- Test method of repeated dose inhalation toxicity: 28/14-day study---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Chemicals Test method of repeated dose inhalation toxicity. 28/14-day study
ICS 13.300; 11.100
A80
National Standards of People's Republic of China
Chemicals 28 days/14 day repeat dose
Inhalation toxicity testing
Posted 2008-05-12
2008-09-01 implementation
Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China
Standardization Administration of China released
Foreword
This standard is identical with the Organisation for Economic Co-operation and Development (OECD) Chemicals testing guidelines No. 412 (2005), "28 days/14 days weight
Re-dose toxicity test "(in English).
The editorial changes made the following standard.
--- Increasing the scope section;
--- Change the unit of measure of legal units of measurement;
--- Delete the reference section of the OECD.
This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points.
This standard is drafted by. China Center for Disease Control and Prevention of Occupational Health and Poison Control.
Participated in the drafting of this standard. Guangdong CIQ.
The main drafters of this standard. Hou Fenxia, \u200b\u200bXuchong Hui, Chen Qiang, Wenqiao Ling, Liu Zhihong.
OECD Introduction
1. OECD chemical testing guidelines periodically in accordance with the requirements of the development of discipline or a realistic assessment of the needs and animal welfare and make the appropriate
Modifications. The initial repeated dose inhalation study guide uses 412 in 1981, TG412 method revised text more consideration pack
Including draining lymph nodes (draininglymph) including histopathological examination, in addition, also extends to other target organ histopathology of
Inspection, testing and reference guide 407 rodents 28 days repeated dose oral toxicity test, it is recommended to increase the functional check.
2. When the testing and evaluation of an inhaled toxic substances such as gases, dust, mist, vapor, aerosols or volatile substances or particulate suspended matter,
Repeated exposure inhalation toxicity can be measured after the acute test data were obtained. It provides after inhalation exposure over time and cause health
Information Kang damage. Inhalation of substances hazardous to their inherent toxicity and physical factors (such as volatility) and particle size.
3. Since the 28-day and 14-day repeat dose inhalation study there is sufficient similarity, so you can use a guide to test two covers
Different test period of the test. The main difference between the two is due to the different exposure time, resulting in different clinical examination and pathological examination.
4. The guidelines for hazard assessment and hazard classification information. It provides information about the hazards and the test substance may be by acute toxicity
The United Nations carried out "Classification and Labeling of Chemicals Globally Harmonized System" (GHS) classification of substances. Known corrosive and irritant so serious
It can cause severe pain and suffering of the test substance without this test, because these substances are recognized as the GHS classification Ⅰ. Dying or Ariake
Significant pain or suffering of animals, or have significant toxicity symptoms in animals should be humanely killed, sacrificed animals during the interpretation of results is as
Into the test animals died. Under what circumstances should be humanely killed moribund or severely suffering animals, and how to identify animal about to die
Death, judgment relevant standards and guidance see the guidance document to another principle.
Chemicals 28 days/14 day repeat dose
Inhalation toxicity testing
1 Scope
This standard specifies the animal 28d/14d repeated dose toxicity test scope, normative references, terms and definitions, test
Basic principles, test methods, test data and reports.
This standard applies to chemicals 28d/14d repeated dose inhalation toxicity determination.
2 Terms and definitions
The following terms and definitions apply to this standard.
2.1
Solid particles or liquid droplets suspended in a gas formed suspension.
2.2
Capable of being suspended in the air or a mixture of solid particulate matter from the formation. These particles of irregular shape and size from less than 1μm
To 100μm range.
2.3
After exposure appears clear poisoning. If using a fixed concentration when exposed to higher animals can cause severe pain, pain
Suffering or dying, most animals may die. Weight is described a "significant toxicity" of a key, you should pay close attention to weight loss
20% of the animals.
2.4
According to the degree of the physical hazards of chemicals, health and the environment, in accordance with uniform standards for the classification of chemicals. Then, according to
Classification of chemicals and the harmful effects of its label to protect human health and the environment, the label is through pictograms, marking graph
Hazard statements, warning instructions and safety data sheets and other means of communication to convey information about the harmful effects of chemicals. GHS is issued by the Economic Cooperation
Development Organization (OECD) (human health and the environment), the United Nations Committee of Experts on the Transport of Dangerous Goods (UNCETDG) (physicochemical properties) and international
ILO (ILO) (chemical hazard information transfer transport) jointly initiated an activity participation by the Inter-agency management of chemicals regulation
Plan Organization (IOMC) harmonization.
2.5
Test animals may appear to be predictive of severe pain or suffering on the verge of some early poisoning death state.
2.6
Animals dying or death may state in the observation period has not ended. Rodent dying symptoms include convulsions, lateral,
Recumbency and tremors.
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