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GB/T 15670.2-2017: Toxicological test methods for pesticides registration -- Part 2: Acute oral toxicity test -- Horn method
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| GB/T 15670.2-2017 | English | 239 |
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Toxicological test methods for pesticides registration -- Part 2: Acute oral toxicity test -- Horn method
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GB/T 15670.2-2017
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Basic data | Standard ID | GB/T 15670.2-2017 (GB/T15670.2-2017) | | Description (Translated English) | Toxicological test methods for pesticides registration -- Part 2: Acute oral toxicity test -- Horn method | | Sector / Industry | National Standard (Recommended) | | Classification of Chinese Standard | B17 | | Classification of International Standard | 65.100 | | Word Count Estimation | 12,189 | | Date of Issue | 2017-07-12 | | Date of Implementation | 2018-02-01 | | Older Standard (superseded by this standard) | GB/T 15670-1995 Partly | | Quoted Standard | GB 14925 | | Issuing agency(ies) | General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China | | Summary | This standard specifies the basic principles, methods and requirements of the acute oral toxicity test. This standard applies to acute oral toxicity tests for pesticide registration. | GB/T 15670.2-2017: Toxicological test methods for pesticides registration -- Part 2: Acute oral toxicity test -- Horn method
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Toxicological test methods for pesticides registration. Part 2. Acute oral toxicity test. Horn "" s method
ICS 65.100
B17
National Standards of People's Republic of China
Partially replace GB/T 15670-1995
Pesticide registration Toxicology test methods
Part 2. Acute oral toxicity test Horn's method
Part 2.Acuteoraltoxicitytest-Horn'smethod
2017-07-12 Posted
2018-02-01 implementation
General Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China
China National Standardization Administration released
Foreword
GB/T 15670 "pesticide registration toxicology test method" is divided into the following sections.
--- Part 1. General principles;
--- Part 2. Acute oral toxicity test Horn's method;
--- Part 3. Acute oral toxicity test sequential method;
--- Part 4. Acute oral toxicity test probability unit method;
--- Part 5. Acute dermal toxicity test;
--- Part 6. Acute inhalation toxicity test;
--- Part 7. Skin irritation/corrosivity test;
--- Part 8. Acute eye irritation/corrosiveness test;
--- Part 9. Skin allergy (sensitization) test;
--- Part 10. Short-term repeated oral toxicity (28 days) toxicity test;
--- Part 11. Short-term repeated transdermal (28 days) toxicity test;
--- Part 12. Short-term repeated inhalation exposure (28 days) toxicity test;
--- Part 13. Subchronic toxicity test;
--- Part 14. bacterial recovery mutation test;
--- Part 15. In vivo mammalian bone marrow polychromatic erythrocyte micronucleus test;
--- Part 16. In vivo mammalian bone marrow cell chromosome aberration test;
--- Part 17. Mammalian spermatogonial/spermatocyte chromosome aberration test;
--- Part 18. Rodent dominant lethality test;
--- Part 19. In vitro mammalian chromosome aberration test;
--- Part 20. In vitro mammalian cell gene mutation test;
--- Part 21. In vivo mammalian hepatocyte extracellular DNA synthesis (UDS) test;
--- Part 22. DNA damage and repair in vitro mammalian cells/DNA synthesis test outside the program;
--- Part 23. Teratogenicity test;
--- Part 24. Two generations of reproductive toxicity test;
--- Part 25. Acute delayed neurotoxicity test;
--- Part 26. Chronic toxicity test;
--- Part 27. Carcinogenicity test;
--- Part 28. Chronic toxicity and carcinogenicity combined test;
--- Part 29. Metabolism and toxicokinetic tests.
This section GB/T 15670 Part 2.
This section drafted in accordance with GB/T 1.1-2009 given rules.
Part of this section instead of GB/T 15670-1995 "pesticide registration toxicology test methods."
This section and GB/T 15670-1995 Acute oral toxicity test section compared to the main changes are as follows.
--- Introduced in more detail the basic principles, methods and requirements of Horn's method for acute oral toxicity test;
--- Modify and adjust the standard of the overall structure and layout format;
--- According to the standard unified requirements added some chapters and content (see Chapter 1, Chapter 2, Chapter 3, Chapter 5, 6.3, Chapter 8);
--- Increased Appendix A "Horn's geometric dose estimated LD50 value and 95% confidence interval table."
This part is proposed and managed by the Ministry of Agriculture of the People's Republic of China.
This part of the drafting unit. Ministry of Agriculture pesticide test.
The main drafters of this section. He Xiwen, Zhang Liying, Qu 甍 甍, Tao Chuanjiang.
This part replaces the standards previously issued as.
--- GB/T 15670-1995.
Pesticide registration Toxicology test methods
Part 2. Acute oral toxicity test Horn's method
1 Scope
This section GB/T 15670 specifies the basic principles, methods and requirements of Horn's test for acute oral toxicity test.
This section applies to pesticides registered acute oral toxicity test.
2 Normative references
The following documents for the application of this document is essential. For dated references, only the dated version applies to this article
Pieces. For undated references, the latest edition (including all amendments) applies to this document.
GB 14925 laboratory animal environment and facilities
Pesticide registration information requirements (People's Republic of China Ministry of Agriculture Order 〔2007〕 No. 10)
3 Terms and definitions
The following terms and definitions apply to this document.
3.1
Acute oral toxicity of acuteoraltoxicity
The effects of health damage to animals in the short term after one or more oral administration of the test animal substance within 24 hours.
3.2
Dose dose
The amount of test substance given is expressed as mass of test article received per unit body weight of test animal (mg/kg body weight).
3.3
Median lethal dose medianlethaldose
LD50
Once or within 24 hours of repeated administration of test animal compounds, the overall experimental animals caused half of the total dose of toxicants statistics.
The test animal's body weight to accept the test substance mass (mg/kg body weight).
3.4
Dose-response relationship dose-responserelationship
Relationship between dose and incidence of specific effects.
4 test purposes
Acute oral toxicity test is to assess the toxicity of the first step. Through a short period of oral exposure to a preliminary understanding of the toxicological characteristics of the test substance
And dose-response relationship, provide a basis for the selection of dose for acute toxicity grading, label management and other toxicological tests.
5 Test Overview
Horn's method is also called modified Vickers law or simplified probability unit method. Using four successive doses of the geometric series,
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