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GB/T 15670.14-2017: Toxicological test methods for pesticides registration -- Part 14: Bacterial reverse mutation test
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Toxicological test methods for pesticides registration -- Part 14: Bacterial reverse mutation test
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GB/T 15670.14-2017
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Basic data | Standard ID | GB/T 15670.14-2017 (GB/T15670.14-2017) | | Description (Translated English) | Toxicological test methods for pesticides registration -- Part 14: Bacterial reverse mutation test | | Sector / Industry | National Standard (Recommended) | | Classification of Chinese Standard | B17 | | Classification of International Standard | 65.100 | | Word Count Estimation | 15,120 | | Date of Issue | 2017-07-12 | | Date of Implementation | 2018-02-01 | | Older Standard (superseded by this standard) | GB/T 15670-1995 Partly | | Issuing agency(ies) | General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China | | Summary | This standard specifies the basic principles, methods and requirements for bacterial response mutagenesis tests. This standard applies to the bacterial response mutation test for pesticide registration. | GB/T 15670.14-2017: Toxicological test methods for pesticides registration -- Part 14: Bacterial reverse mutation test
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Toxicological test methods for pesticides registration. Part 14. Bacterial reverse mutation test
ICS 65.100
B17
National Standards of People's Republic of China
Partially replace GB/T 15670-1995
Pesticide registration Toxicology test methods
Part 14 - Bacterial reversion mutation test
Part 14.Bacterialreversemutationtest
2017-07-12 Posted
2018-02-01 implementation
General Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China
China National Standardization Administration released
Foreword
GB/T 15670 "pesticide registration toxicology test method" is divided into the following sections.
--- Part 1. General principles;
--- Part 2. Acute oral toxicity test Horn's method;
--- Part 3. Acute oral toxicity test sequential method;
--- Part 4. Acute oral toxicity test probability unit method;
--- Part 5. Acute dermal toxicity test;
--- Part 6. Acute inhalation toxicity test;
--- Part 7. Skin irritation/corrosivity test;
--- Part 8. Acute eye irritation/corrosiveness test;
--- Part 9. Skin allergy (sensitization) test;
--- Part 10. Short-term repeated oral toxicity (28 days) toxicity test;
--- Part 11. Short-term repeated transdermal (28 days) toxicity test;
--- Part 12. Short-term repeated inhalation exposure (28 days) toxicity test;
--- Part 13. Subchronic toxicity test;
--- Part 14. bacterial recovery mutation test;
--- Part 15. In vivo mammalian bone marrow polychromatic erythrocyte micronucleus test;
--- Part 16. In vivo mammalian bone marrow cell chromosome aberration test;
--- Part 17. Mammalian spermatogonial/spermatocyte chromosome aberration test;
--- Part 18. Rodent dominant lethality test;
--- Part 19. In vitro mammalian chromosome aberration test;
--- Part 20. In vitro mammalian cell gene mutation test;
--- Part 21. In vivo mammalian hepatocyte extracellular DNA synthesis (UDS) test;
--- Part 22. DNA damage and repair in vitro mammalian cells/DNA synthesis test outside the program;
--- Part 23. Teratogenicity test;
--- Part 24. Two generations of reproductive toxicity test;
--- Part 25. Acute delayed neurotoxicity test;
--- Part 26. Chronic toxicity test;
--- Part 27. Carcinogenicity test;
--- Part 28. Chronic toxicity and carcinogenicity combined test;
--- Part 29. Metabolism and toxicokinetic tests.
This section GB/T 15670 Part 14.
This section drafted in accordance with GB/T 1.1-2009 given rules.
Part of this section instead of GB/T 15670-1995 "pesticide registration toxicology test methods."
This section and GB/T 15670-1995 Salmonella typhimurium back to the test part of the main changes are as follows.
--- Modify and adjust the standard of the overall structure and layout format;
--- Added some chapters (see Chapter 1, Chapter 2, Chapter 4, 5.6, 5.7, 6.3, 7.3.2, 7.3.3 and Chapter 9);
--- Revised part of the reagent formulation (see 5.3,.1995 edition of 14.3.3);
--- Modify the requirements of the test strains (see 6.1,.1995 edition of 14.3.1);
--- Modified dose and grouping (see 7.2,.1995 edition 14.3.4);
--- Modify the content of the outcome of the decision (see 8.2,.1995 edition of 14.3.8).
This part is proposed and managed by the Ministry of Agriculture of the People's Republic of China.
This part of the drafting unit. Ministry of Agriculture pesticide test.
The main drafters of this section. Xiao Hang, Central, fly, Zhang Liying, Tao Chuanjiang.
This part replaces the standards previously issued as.
--- GB/T 15670-1995.
Pesticide registration Toxicology test methods
Part 14 - Bacterial reversion mutation test
1 Scope
This section GB/T 15670 specifies the basic principles, methods and requirements of bacterial reversion mutation test.
This section applies to the registration of pesticides for bacterial mutation test.
2 Terms and definitions
The following terms and definitions apply to this document.
2.1
Reverse mutation test reversemutationtest
Using a panel of Salmonella typhimurium and/or Escherichia coli to detect chemicals that cause bacterial base-replacement or frameshift mutations
Strains requiring certain amino acids (histidine or tryptophan, respectively) become mutations of strains that do not require exogenous supply of amino acids, that is,
The auxotrophic back changes to the wild type.
2.2
Base substitutions mutagens basepairsubstitutionmutagens
A substance that causes the replacement of one or more base pairs in a DNA molecule. In a back-mutation test, this change may occur in bacterial genes
Group of the original site of mutation or another site.
2.3
Frameshift mutagens
A substance that causes the DNA molecule to increase or lose one or more base pairs.
3 test purposes
Test the mutagenicity of the test substance to predict its genetic risk and potential carcinogenic potential.
4 Test Overview
Bacterial Reactivation Mutation Test Salmonella typhimurium and Escherichia coli are used to detect point mutations involving one or several bases of DNA
Replacement, insertion or deletion of pairs. The principle is by observing the growth of the test strain on a medium lacking the amino acids required, a test
Verify that the strain is capable of recovering the essential amino acids and evaluating the ability of the test substance to induce mutations.
5 Media and reagents
Note. Media components or reagents should be at least chemically pure, non-mutagenic. Avoid repeated heat treatment, choose the appropriate storage temperature and deadline, such as broth preserved in
4 ℃ not more than 6 months, the other details see the following media and solution instructions.
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