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Technical specification for biosafety control of animal experiments with pathogenic infections
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Basic data
| Standard ID | GB/T 47222-2026 (GB/T47222-2026) |
| Description (Translated English) | Technical specification for biosafety control of animal experiments with pathogenic infections |
| Sector / Industry | National Standard (Recommended) |
| Classification of Chinese Standard | B41 |
| Classification of International Standard | 11.220 |
| Word Count Estimation | 14,122 |
| Date of Issue | 2026-02-27 |
| Date of Implementation | 2026-09-01 |
| Issuing agency(ies) | State Administration for Market Regulation, Standardization Administration of China |
GB/T 47222-2026: Technical specification for biosafety control of animal experiments with pathogenic infections
---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
ICS 11.220
CCSB41
National Standards of the People's Republic of China
Biosafety Control Technical Specifications for Animal Experiments with Pathogen Infection
pathogenic infections
Implemented on 2026-09-01
State Administration for Market Regulation
The State Administration for Standardization issued a statement.
Table of contents
Preface III
Introduction IV
1.Scope 1
2 Normative References 1
3.Terms and Definitions 1
4.Risk Assessment 2
5.Requirements for pre-experiment preparation activities 2
5.1 2 Experimenters
5.2 Facilities and Equipment 2
5.3 Laboratory Animals 3
6.Experimental Activity Requirements 3
6.1 Management and Transfer of Bacterial (Viral) Strains and Infectious Samples 3
6.2 Animal capture/restraint 4
6.3 Analgesia and Anesthesia 4
6.4 Inoculation and Administration 4
6.5 Sample Collection 4
6.6 The care of infected animals 5
6.7 Euthanasia 5
6.8 Autopsy and Sampling 5
6.9 Disinfection and Cleaning 5
6.10 Waste Disposal 5
7 Emergency Response Plan 6
8.Record and file management 7.
Foreword
This document complies with the provisions of GB/T 1.1-2020 "Standardization Work Guidelines Part 1.Structure and Drafting Rules of Standardization Documents".
Drafting.
Please note that some content in this document may involve patents. The issuing organization of this document assumes no responsibility for identifying patents.
This document was proposed by the Ministry of Agriculture and Rural Affairs of the People's Republic of China.
This document is under the jurisdiction of the National Technical Committee on Animal Health Standardization (SAC/TC181).
This document was drafted by. China National Accreditation Service for Conformity Assessment (CNAS), Qingdao Customs Technology Center, and China Animal Health and Epidemiology Center.
Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Shandong Provincial Animal Disease Prevention and Control Center, and Chinese Center for Disease Control and Prevention (CDC) Virus Disease Prevention and Control Center
Institute of Disease Control and Prevention, China Institute of Veterinary Drug Control, Beijing Municipal Office of Laboratory Animal Management, Guangdong Provincial Center for Laboratory Animals, Guangzhou Customs Technology
Center, Chongqing Municipal Animal Disease Prevention and Control Center, and Gannan Innovation and Translational Medicine Research Institute.
The main drafters of this document are. Tao Yufeng, Zhang Qian, Wang Junwei, Sun Hongtao, Guan Yuntao, Fu Hongkun, Fan Wei, Li Muyang, Wang Miaoli, and Xu Biao.
Yao Wensheng, Li Genping, Han Jun, Liu Yonggang, Wang Gang, Lin Zhixiong, Lan Zouran, Ding Ning, Xu Yun, Luo Lu, Li Hongliang.
Introduction
This document aims to reduce the risks of pathogen infection in animal experiments, with a focus on biosafety control. Currently, my country's biosafety...
Relevant national standards include GB 19489 "General Requirements for Laboratory Biosafety" and GB 50346 "Technical Specifications for Biosafety Laboratory Buildings".
Standards such as GB/T 35823 "General Requirements for Laboratory Animal Experiments" mainly address laboratory management, laboratory building facilities, and laboratory animals.
While general requirements are set, there are currently no technical guidelines for biosafety control throughout the entire process, from pre-experiment preparation and experimental operations to experimental waste disposal.
There is an urgent need to develop national standards that guide the development of technical standards for biosafety control throughout the entire process of animal experiments involving pathogen infection.
This document focuses on the biosafety control of animal experiments involving pathogen infection, comprehensively reviewing the biosafety aspects of experimental procedures.
This document identifies key risk points and proposes preventative measures for these risks. It not only provides guidance for each operational step in animal experiments involving pathogen infection, but also addresses these risks.
How to provide comprehensive technical guidance for preventing biosafety risks, prevent and control potential hazards, and provide support for subsequent actions after a hazard occurs?
Provide scientific advice for effective handling.
Biosafety Control Technical Specifications for Animal Experiments with Pathogen Infection
1 Scope
This document specifies the risk assessment, pre-experiment preparation, experiment implementation, emergency plans, records, and documentation procedures for animal experiments involving pathogen infection.
General requirements for biosafety control in case management.
This document applies to biosafety control in animal experiments involving pathogen infection in animal biosafety laboratories.
2 Normative references
The contents of the following documents, through normative references within the text, constitute essential provisions of this document. Dated citations are not included.
For references to documents, only the version corresponding to that date applies to this document; for undated references, the latest version (including all amendments) applies.
This document.
GB 8978 Integrated Wastewater Discharge Standard
GB 14925 Laboratory Animal Environment and Facilities
GB 15562.2 Environmental Protection Graphic Symbols for Solid Waste Storage (Disposal) Sites
GB/T 15981 Evaluation Method for Sterilization Efficacy of Disinfected Instruments
GB 18466 Standard for Water Pollutant Discharge from Medical Institutions
GB 18597 Standard for Pollution Control of Hazardous Waste Storage
GB 19489 General Requirements for Laboratory Biosafety
GB/T 39759 Terminology for Laboratory Animals
GB/T 39760 Guidelines for Euthanasia of Laboratory Animals
GB/T 43051 General Requirements for Biosafety in Laboratory Animals
GB 50346 Technical Specification for Biosafety Laboratory Construction
GB 50447 Technical Specifications for the Construction of Laboratory Animal Facilities
3 Terms and Definitions
The terms and definitions defined in GB/T 39759 and the following terms and definitions apply to this document.
3.1
Scientific research, teaching, testing, and other scientific experiments conducted using pathogen-infected laboratory animals or laboratory animals.
3.2
Terminal disinfection
After the experiment, a thorough disinfection is carried out to eliminate any pathogenic microorganisms that may remain in the experimental area.
3.3
laboratory waste
Substances generated during the experiment that have lost their value to the original user and are discarded or require disposal for reuse.
3.4
Infectious waste
Waste generated during animal experiments that contains or may contain pathogenic microorganisms and pose a risk of disease transmission to human or animal health.
...
