GB/T 21767-2008 English PDF

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GB/T 21767-2008: Chemical -- Test method of unscheduled DNA synthesis (UDS) test with mammalian liver cells In Vivo
Status: Valid

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 21767-2008	154	Add to Cart	3 days	Chemical -- Test method of unscheduled DNA synthesis (UDS) test with mammalian liver cells In Vivo	Valid

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Basic data

Standard ID: GB/T 21767-2008 (GB/T21767-2008)
Description (Translated English): Chemical -- Test method of unscheduled DNA synthesis (UDS) test with mammalian liver cells In Vivo
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: A80
Classification of International Standard: 13.300; 11.100
Word Count Estimation: 8,825
Date of Issue: 2008-05-12
Date of Implementation: 2008-09-01
Adopted Standard: OECD No.486-1997, IDT
Regulation (derived from): Announcement of Newly Approved National Standards No. 7 of 2008 (No. 120 overall)
Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China
Summary: This standard specifies the chemical DNA synthesis in vivo mammalian test program scope, terms and definitions, test basic principles, test methods, test data and reports. This standard is applicable to the detection of liver cells can induce DNA damage in experimental animals and repair chemicals.

GB/T 21767-2008: Chemical -- Test method of unscheduled DNA synthesis (UDS) test with mammalian liver cells In Vivo

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Chemical.Test method of unscheduled DNA synthesis (UDS) test with mammalian liver cells In Vivo ICS 13.300; 11.100 A80 National Standards of People's Republic of China Chemicals mammalian liver cells in vivo unscheduled DNA synthesis (UDS) Test Method Posted 2008-05-12 2008-09-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released

Foreword

This standard is identical with the Organisation for Economic Co-operation and Development (OECD) Chemicals testing guidelines No. 486 (1997) "in vivo mammalian hepatocytes Cellular unscheduled DNA synthesis (UDS) test "(in English). The editorial changes made the following standard. --- Increasing the scope section; --- Deleted the reference section of the OECD; --- Will introduce and test methods OECD principles of the original merger. This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points. This standard is drafted by. Guangdong CIQ. Participated in the drafting of this standard. Shanghai CIQ. The main drafters of this standard. Cheng Shujun, Xuchong Hui, Jiao Hong, Lu Qiu, Chen Gufeng, Li Jian, PAN Fang, Li Qingxiang. Chemicals mammalian liver cells in vivo unscheduled DNA synthesis (UDS) Test Method

1 Scope

This standard specifies the scope of chemicals in vivo mammalian unscheduled DNA synthesis test, the terms and definitions, basic test principle, Test methods, test data and reports. This standard is applicable to the detection of liver cells of experimental animals can induce DNA damage and repair chemicals. 2 Terms and definitions, abbreviations 2.1 Terms and Definitions The following terms and definitions apply to this standard. 2.1.1 Defined as the net nuclear silver grain (NNG) higher than the cells of the laboratory historical negative control values. 2.1.2 UDS test for the quantitative determination of the activity of radiation UDS from the developing cells by nuclear silver grains (NG) is equal to minus nuclear The average number of silver particles within the cytoplasm area (CG) to calculate that NNG = NG-CG. Normally evaluated every cell of NNG, then A culture or parallel cultures of cells NNG summary. 2.1.3 DNA chemical or physical agents cause DNA damage after repair synthesis, cell cycle progression and S according to the program occurred Different semi-conservative synthesis of DNA, called unscheduled DNA synthesis. 2.2 Acronyms The following abbreviations apply to this standard. EINECS (EuropeanInventoryofExistingCommercialChemicalSubstances). European Inventory of Existing Commercial Chemical Catalog NG (nucleargrains). Nuclear silver grains CG (cytoplasmicgrains). cytoplasm silver grains

3 test basic principles

In vivo mammalian purpose unscheduled DNA synthesis test is to identify infected animals can induce DNA repair in liver cells substance. In vivo test provides a research chemical liver toxicity effect of genetic methods, the end of the test showed that the liver cells DNA Damage and Repair ensued. The liver is the main organ of the body's metabolism of chemicals absorbed, so the liver is the in vivo detection of DNA damage Suitable injury site. After the chemical or physical factors induce DNA damage, cells start unscheduled DNA synthesis procedures to excise or remove DNA damage Area, in vivo mammalian liver UDS test is to detect cells repair damaged DNA synthesis. Liver cell cycle in S phase Frequency is low, so the test is usually detected by autoradiography of tritiated thymidine (3H-TdR) incorporation of hepatocytes ......

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