GB/T 21757-2008 English PDFUS$274.00 ยท In stock
Delivery: <= 3 days. True-PDF full-copy in English will be manually translated and delivered via email. GB/T 21757-2008: Chemicals -- Test method of acute oral toxicity for chemicals -- Acute toxic class method Status: Valid
Basic dataStandard ID: GB/T 21757-2008 (GB/T21757-2008)Description (Translated English): Chemicals -- Test method of acute oral toxicity for chemicals -- Acute toxic class method Sector / Industry: National Standard (Recommended) Classification of Chinese Standard: A80 Classification of International Standard: 13.300; 11.100 Word Count Estimation: 14,189 Date of Issue: 2008-05-12 Date of Implementation: 2008-09-01 Adopted Standard: OECD No.423-2001, IDT Regulation (derived from): Announcement of Newly Approved National Standards No. 7 of 2008 (No. 120 overall) Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China Summary: This standard specifies the acute oral toxicity test acute toxicity test purposes taxonomy, terminology and definitions, test basic principles, test methods, test data and reports. This standard is applicable to the detection of acute oral toxicity of chemicals classification tests. GB/T 21757-2008: Chemicals -- Test method of acute oral toxicity for chemicals -- Acute toxic class method---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order. Chemicals. Test method of acute oral toxicity for chemicals. Acute toxic class method ICS 13.300; 11.100 A80 National Standards of People's Republic of China Chemicals acute oral toxicity test Acute toxicity classification Posted 2008-05-12 2008-09-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released ForewordThis standard is identical with the Organisation for Economic Co-operation and Development (OECD) Chemicals testing guidelines No. 423 "Chemical acute oral toxicity test Acute toxicity test Classification "(2001) (in English). The editorial changes made the following standard. --- Increased the preamble; --- Increased OECD introduction, the original content in the initial test OECD notes into OECD introduction; --- Deleted the reference section of the OECD. The Standard Appendix A and Appendix B are normative appendix. This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points. This standard is drafted by. Guangdong CIQ. Participated in the drafting of this standard. Shanghai CIQ. The main drafters of this standard. Xuchong Hui, Cheng Shujun, Jiao Hong, PAN Fang, Wenqiao Ling, Chen Gufeng, Qiu Lu, Liu Junping, Li Qingxiang. OECD Introduction 1. OECD chemical testing guidelines periodically as needed discipline development or actual assessments and amended accordingly. The initial 423 The method of the text approved in March 1996, is as acute toxicity testing second conventional method, and the method described in the then 401 text. Because 1) Available LD50 values \u200b\u200bfor rough classification of chemical substances; and 2) a single sex (normally females) test is adequate, these two Reaching consensus, and therefore several expert meetings have suggested modifications to the original text. 2. Acute toxicity classification, each step using three single-sex animal testing methods, based on animal mortality and/or frequency Sizhuang State, after 2 to 4 steps can assess acute toxicity substance, the method is repeatable, uses very little animals get other acute Toxicity method (Test Method 420 and 425) taxonomy. Acute toxicity classification method using a fixed dose and the larger dose spacing and biology Evaluation, classification and reach toxic substance hazard assessment purposes. Since the 1996 adoption of the text have foreign literature in vitro and in vivo obtained Broad support. 3. According to experimental purposes, you can find the most appropriate method of detecting oral toxicity testing guidelines, but also in the text of the guidelines, you can also To find additional information about the 423 method. 4. The term of the present method of text found in the Appendix. 5. Under certain dose primary corrosive or severe injury, can cause intense pain or animals should not damage the test substance orally I. Frequency dead animals or severe persistent painful symptoms of animals should be humanely killed, and annotate experimental results in death. How decisions Fixed-frequency dead animals and predict how animals are going to die, you can see the guidance document relevant content. 6. This method was tested in Keyijuben Classification and Labeling of Chemicals Globally Harmonized System (GHS) classification for acute toxicity of the test substance into the Row dose and results forecast. 7. In principle, this method does not calculate the precise LD50, but like other death as the end of the test, as a given Lethal dose range. The method of at least two Group Dose mortality rate is greater than or less than 0% to 100%, the LD50 values \u200b\u200bcan be calculated by experiment Dose design, determine the number of animal experiments in different toxic effects, but also determines the laboratory test reports and the accuracy and repeatability. 8. The relative test operation, the test substance should be studied as possible relevant information collected prior to the test. This information includes physical characteristics, chemical Structure, physical and chemical properties, toxicity test results of the test object inside and outside and with structurally similar substances toxicology information and use of the test substance, these Experimental data in favor of the protection of human and selection of the appropriate starting dose. Chemicals acute oral toxicity test Acute toxicity classification1 ScopeThis standard specifies the acute oral toxicity test Acute toxicity test object classification test, the terms and definitions, basic test principle, Test methods, test data and reports. This standard is applicable to the detection of acute oral toxicity of chemicals classification tests.2 test purposesWith fewer animals (not more than 12), and gradually test, the test to determine the acute oral toxicity of the substance and its classification.3 Terms and DefinitionsThe following terms and definitions apply to this standard. 3.1 Test substance once or several times within 24h orally administered a dose of the harmful effects of the test animals caused. 3.2 Animal death or near-death does not occur within 48h after exposure, but from the subsequent observation period 14d. 3.3 A given amount of the test substance, often mass (g, mg) or as mass per body weight of the subject animal of the test substance (mg/kg) is represented. 3.4 Moribund or dead is expected to appear before the next observation period. The performance of this state in rodents indications include convulsions, lateral, lying Lying does not move, chills and so on. 3.5 Disposable oral administration of the test substance is expected to cause 50% of the dose animal was dead, LD50 value per body weight in animals receiving test Quality material (mg/kg) to represent. 3.6 The upper limit of the test dose (2000mg/kg or 5000mg/kg). 3.7 Animals are dying or even medical treatment can not be viable state. 3.8 Clinical indications show at a certain time during the experiment will appear death, such as not eating and drinking. ......Tips & Frequently Asked Questions:Question 1: How long will the true-PDF of GB/T 21757-2008_English be delivered?Answer: Upon your order, we will start to translate GB/T 21757-2008_English as soon as possible, and keep you informed of the progress. The lead time is typically 1 ~ 3 working days. 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