GB/T 21797-2008 English PDFUS$154.00 ยท In stock
Delivery: <= 3 days. True-PDF full-copy in English will be manually translated and delivered via email. GB/T 21797-2008: Testing of chemicals -- Delayed neurotoxicity of organophosphorus substances 28-day repeated dose study Status: Valid
Basic dataStandard ID: GB/T 21797-2008 (GB/T21797-2008)Description (Translated English): Testing of chemicals -- Delayed neurotoxicity of organophosphorus substances 28-day repeated dose study Sector / Industry: National Standard (Recommended) Classification of Chinese Standard: A80 Classification of International Standard: 13.300; 11.100 Word Count Estimation: 8,886 Date of Issue: 2008-05-12 Date of Implementation: 2008-09-01 Adopted Standard: OECD No.419-1995, IDT Regulation (derived from): Announcement of Newly Approved National Standards No. 7, 2008 (No. 120 overall) Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China Summary: This standard specifies the chemical organophosphorus compound 28 day repeat dose of delayed neurotoxicity test terminology and definitions, test basic principles, test procedures, test reports and interpretation of results. This standard is applicable to the detection of organophosphorus compounds chemicals on the nervous system of delayed neurotoxicity. GB/T 21797-2008: Testing of chemicals -- Delayed neurotoxicity of organophosphorus substances 28-day repeated dose study---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order. Testing of chemicals. Delayed neurotoxicity of organophosphorus substances 28-day repeated dose study ICS 13.300; 11.100 A80 National Standards of People's Republic of China Chemical organophosphorus compound 28 days delayed neurotoxicity repeated dose study Posted 2008-05-12 2008-09-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released ForewordThis standard is identical with the Organisation for Economic Co-operation and Development (OECD) guidelines for testing of chemicals No. 419 (1995), "an organic phosphorus compound 28 days repeated dose delayed neurotoxicity test "(in English). This standard made the following editorial changes. --- Will be presented and mind allegiance to merge part of OECD OECD Introduction; --- Increasing the scope; --- The definition of the appendix to move the body; --- The units of measurement to our legal units of measurement; --- Delete the reference section of the OECD. This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points. This standard is drafted by. Environmental Protection Department of Chemical Registration Center. Participated in the drafting of this standard. Shenyang Research Institute of Chemical Safety Evaluation Center, China Environmental Science Research Institute, China National Disease Control Heart, Ningbo CIQ. The main drafters of this standard. Liao Xue, Lu Yao, Zhou Hong, Li Handong, Lin Zhenxing, Ma Zhongchun, then Long Hao, Chen Xiaoqing. OECD Introduction 1. OECD guidelines based on scientific considerations and the latest developments in animal welfare guidelines regularly to test changes in this update include measuring guide The amount of neuropathy target esterase (NTE; formerly known neurotoxic esterase) Amendment effect method. 24h ~ 48h after exposure on the brain and spinal cord NTE inhibition and clinical and morphological effects of delayed neurotoxicity have a good correlation. It has been found that NTE test model There are known to cause human nerve disorder tardive organophosphorus esters are valid. Thus, in certain subclinical or organization Is not clear, the quantitative data NTE inhibition will significantly improve pathological data of these phenomena for potential delayed neurotoxicity Judgment. Different 90d exposure period with the last version of the requirements of this amendment requires at least exposed to 28d. Typically 28d repeat Repeated exposure dose sufficient to effectively evaluate organic phosphorus compound induced delayed neuropathy. For most pesticides, the contact method to 28d More realistic than 90d contact manner. 2. The guide 419 is an updated version from the working group of experts in February 1992, held in Paris on systematic short-term and delayed neurological Toxicity coordination meetings. This updated version is mainly composed especially related neurotoxicity in March 1990, held in Washington OECD test Be revised on the basis of the preliminary meeting to discuss the formation and comments received from the Member States. 3. The guidelines for the evaluation of the toxic effects of organophosphorus compounds. Determination of repeated exposure usually delayed neurotoxicity in acute completed Delayed neurotoxicity test (Guideline 418) conducted after. From neurotoxicity tests and other tests acute late obtained junction Fruit of delayed neurotoxicity test design repeated exposure is helpful. 4.28d delayed toxicity tests available within a specified period of time the test was repeated exposure to health hazard information; and for the dose - response Relations and the development of safe level of exposure of no observed adverse effect dose level (NOAEL) estimates provide information. 5. According to some use of substances (such as plasticizers) may require longer exposure (90d). In some cases, in order to solve the capital extrapolated Explain difficult material, or to find out more detailed some special substance use characteristics, may require further testing. Chemical organophosphorus compound 28 days delayed neurotoxicity repeated dose study1 ScopeThis standard specifies the terms and definitions chemical organophosphorus compound 28 days repeated dose delayed neurotoxicity test, test basic In principle, test procedures, test reports and interpretation of results. This standard is applicable to the detection of chemical organophosphorus compound on the nervous system delayed neurotoxicity.2 Terms and definitionsThe following terms and definitions apply to this standard. 2.1 It refers to a group of neurological syndromes, mainly for the late emergence of ataxia, spinal cord and peripheral nerve axons away disease, and nerve Tissue neuropathy target esterase inhibition and aging. 2.2 It includes uncharged organic phosphate, phosphorothioate, or an organic phosphoric anhydride, organic phosphonic acid, phosphoric acid or an organic acid amide or a sulfur related On behalf of the phosphoric acid, thio acid or thio acid phosphoramidite, or other such cause neurotoxic substances.3 test basic principlesWith the test substance once daily oral administration of domesticated hen, a total of 28d. At least once a day to observe whether there are abnormal animal behavior, ataxia And paralysis, continuous observation until after the cessation of exposure 14d. After the last treatment (typically 24h and 48h), animals in each group were randomly selected students Of the inspection, especially measured neuropathy target esterase (neuropathytargetesterase, NTE). After the last exposure 14d, killed survival Hen, nerve tissue histopathological examination.4 Test Procedure4.1 Experimental Animals 4.1.1 animal species system. Animals should be brought up in the free exercise of environmental conditions. 4.1.2 rearing environment Under normal conditions hens, caged; cages should be large enough to allow animals to move freely and easily observed gait; adopt When artificial lighting to maintain a daily light and dark 12h 12h, should be given appropriate feed and water ad libitum. 4.1.3 Animal Preparation Healthy young adult hens use to ensure that no viral disease had not received medication and no abnormal gait, were randomly divided on Exposure group and control group. Prior to testing, animal quarantine acclimation and adaptation to laboratory conditions for at least 5d time. 4.2 Preparation of the test substance and exposure pathways 4.2.1 The oral administration of daily, weekly, 7d, the best choice for capsules or oral exposure mode. ......Tips & Frequently Asked Questions:Question 1: How long will the true-PDF of GB/T 21797-2008_English be delivered?Answer: Upon your order, we will start to translate GB/T 21797-2008_English as soon as possible, and keep you informed of the progress. The lead time is typically 1 ~ 3 working days. The lengthier the document the longer the lead time.Question 2: Can I share the purchased PDF of GB/T 21797-2008_English with my colleagues?Answer: Yes. The purchased PDF of GB/T 21797-2008_English will be deemed to be sold to your employer/organization who actually pays for it, including your colleagues and your employer's intranet.Question 3: Does the price include tax/VAT?Answer: Yes. Our tax invoice, downloaded/delivered in 9 seconds, includes all tax/VAT and complies with 100+ countries' tax regulations (tax exempted in 100+ countries) -- See Avoidance of Double Taxation Agreements (DTAs): List of DTAs signed between Singapore and 100+ countriesQuestion 4: Do you accept my currency other than USD?Answer: Yes. If you need your currency to be printed on the invoice, please write an email to Sales@ChineseStandard.net. In 2 working-hours, we will create a special link for you to pay in any currencies. Otherwise, follow the normal steps: Add to Cart -- Checkout -- Select your currency to pay. |
