GB/T 21787-2008 English PDFUS$299.00 · In stock
Delivery: <= 3 days. True-PDF full-copy in English will be manually translated and delivered via email. GB/T 21787-2008: Chemicals -- Test method of neurotoxicity study in rodents Status: Valid
Basic dataStandard ID: GB/T 21787-2008 (GB/T21787-2008)Description (Translated English): Chemicals -- Test method of neurotoxicity study in rodents Sector / Industry: National Standard (Recommended) Classification of Chinese Standard: A80 Classification of International Standard: 13.300; 11.100 Word Count Estimation: 13,141 Date of Issue: 2008-05-12 Date of Implementation: 2008-09-01 Adopted Standard: OECD No.424-1997, IDT Regulation (derived from): Announcement of Newly Approved National Standards No. 7, 2008 (No. 120 overall) Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China Summary: This standard specifies the rodent neurotoxicity testing scope, terms and definitions, abbreviations, testing basic principles, test methods, test data and reports. This standard is applicable to the detection of neurotoxic chemicals. GB/T 21787-2008: Chemicals -- Test method of neurotoxicity study in rodents---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.Chemicals.Test method of neurotoxicity study in rodents ICS 13.300; 11.100 A80 National Standards of People's Republic of China Chemical rodents neurotoxicity test methods Posted.2008-05-12 2008-09-01 implementation General Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China China National Standardization Administration released ForewordThis standard is identical with the Organization for Economic Co-operation and Development (OECD) Guide to Testing Chemicals. 424 (1997) "Rodent God Toxicity test "(in English). This standard made the following editorial changes. --- Increased range; --- Unit of measurement to legal units of measurement; --- Removed the OECD reference section. This standard Appendix A, Appendix B is a normative appendix. This standard by the National Standardization Technical Committee of hazardous chemicals management (SAC/TC251) and focal point. This standard is drafted by. China Center for Disease Control Occupational Health and Poison Control. Participated in the drafting of this standard. Shanghai Exit Inspection and Quarantine, Ningbo Exit Inspection and Quarantine. The main drafters of this standard. Qiu Lu, Liu Qingjun, Li Chaolin, Chen Xiaoqing, Li Shuang, Lin Zhenxing. OECD Introduction 1. OECD Guide to Testing of Chemicals Conducted on a regular basis, based on advances in science and technology, to enable the identification and generation of hazard related data Maintain full agreement with scientific progress. OECD member countries, OECD Secretariat and international scientific community may propose to establish or renewal of test guide. For procedural guidance on establishing test guidelines see OECD Environmental Specialist No. 76. 2. The OECD Thematic Meeting on Neurotoxicity Testing, held in Washington, D.C., in March.1990 produced the recommendations of this draft test guide, An expert working group coordination meeting on systemic short-term and (delayed) neurotoxicity was held in Paris in February.1992. At these meetings Proposed recommendations and the EPA guidelines on neurotoxicity based on this draft. March.1995 in Ottawa, Canada by the OECD The Ad Hoc Working Group on Neurotoxicity presents the final draft recommendation. The WG considered the coordinating members of the OECD Guidance Project as well as Canada Advice on guidelines for neurotoxicity testing. 3. This test guide provides information on the role of chemicals in causing potential neurotoxicity in adult animals and may further identify potential divine Toxicity characteristics. It can be combined with existing repeat dose toxicity studies, or it can be done alone. Based on this test guideline Experimental design, especially when making modifications to routine observation items and test procedures in this guideline, is recommended with reference to the OECD Guidelines on Neurotoxicity Guidance document on test strategies and methods. The OECD guidance document also facilitates the selection of other test methods in special cases. Developmental neurotoxicity evaluation with separate test guidelines. 4. Neurotoxicity is a very important aspect in the identification and evaluation of toxicological traits of chemicals. Repeated Dose System Toxicity Test The guidelines already include observations of screening for potential neurotoxicity. Tests designed using this test guide will give you more neurotoxicity Sexual information also further confirms the neurotoxic effects observed in repetitive dose system toxicity studies. However, consider certain kinds of chemistry The potential neurotoxicity of the product makes it more reasonable to use the guidelines rather than repeat dose testing to evaluate chemicals. Consider the content due. ● In addition to repeated toxicity testing of toxic systems, this guideline tests other neurological symptoms or neuropathological lesions that may be observed. or ● Information related to or related to the structure of other known neurotoxic agents. 5. Additional guidance applicable to this test guideline may be further referenced in the guidance document on OECD neurotoxicity strategies and methods. 6. This test guideline addresses the specific needs of confirming the specific histopathology and neurobehavioral toxicity of chemicals and is capable of modulating neurotoxicity Response to make a qualitative and quantitative evaluation. 7. In the past, neurotoxicity was considered to be neurology, including neuropathic injury and neurological dysfunction such as epilepsy, paralysis or tremor. Do Neuropathies are an important manifestation of neurotoxicity, but now there is a growing recognition of other neurotoxic effects such as motor coordination Barriers, sensory disturbances, learning and memory dysfunction, etc. are not reflected in neurological or other types of trials. 8. This Neurotoxicity Test Guideline is used to examine the major neurobehavioral and neuropathological changes in adult rodents. Even without shape Morphological changes, the impact on neurological behavior can still reflect the toxic effects of the body, of course, not all of the behavioral changes are the nervous system Unique. Therefore, all observed changes should be combined with relevant pathology, hematology or biochemical data as well as other types of systemic toxicity Material evaluation. This test guideline requires that tests be able to characterize and quantify neurotoxic reactions, including specific histopathology and behavior For academic change, behavioral changes may require further electrophysiological and/or biochemical support. 9. Neurotoxic agents may act on multiple target organs of the nervous system through multiple mechanisms. Thus, no single test can be complete All chemicals are evaluated for potential neurotoxicity and therefore may be used in combination with certain observed or expected specific neurotoxicities In vivo or in vitro test. 10. This test guideline can be combined with the guidance document for the OECD neurotoxicity testing strategy and methodology to design a test for further identification Toxicity profile or dose-response sensitivity to better estimate NOAEL levels or to confirm the known or suspected danger of a chemical Sex. For example, it can be used to identify and evaluate neurotoxic mechanisms or to existing ones that are obtained through basic neurobehavioral and neuropathological observations Information to supplement. If it is relevant information obtained under the standard test procedures recommended in this guideline and does not require solution to the results Release, then do not have to repeat the test. 11. Neurotoxicity tests, used alone or in combination with other tests, provide the following information. ● Identification of test substance on the nervous system is reversible; ● Identify changes in the nervous system caused by chemical exposure to understand specific mechanisms; ● Explore dose-response and time-response relationships to determine NOAEL (safety criteria that can be used to determine chemical exposure). 12. This test guideline applies to oral exposure to test substances. Other exposure routes (such as transdermal or inhaled) of the test also apply, but need Make appropriate changes to the recommended method. The choice of route of exposure should be based on population exposure and available toxicology or toxicokinetics data. Chemical rodents neurotoxicity test methods1 ScopeThis standard specifies the scope of rodents neurotoxicity test, terms and definitions, abbreviations, basic principles of test, test methods, test Test data and reports. This standard applies to the detection of chemical neurotoxicity. 2 Terms and definitions, abbreviations 2.1 Terms and definitions The following terms and definitions apply to this standard. 2.1.1 Any change related to the treatment factors, causing the body to survive, reproductive or environmental adaptive ability to reduce. 2.1.2 The amount of test substance received, often in the quality (g, mg) or animal body weight given by the amount of the test substance (mg/kg) to represent; as will be subject When the test substance is mixed with the feed for infection, it can also be expressed as a constant mass fraction (mg/kg) of the test substance in the feed. 2.1.3 Including the dose of exposure, the number of exposure and the duration of exposure, including the general terms. 2.1.4 Detrimental changes in the structure or function of the nervous system caused by exposure to chemical, biological or physical factors. 2.1.5 A chemical, biological, or physical agent that can cause neurotoxicity. 2.1.6 The highest dose of no toxic effects was found. 2.2 Abbreviations The following abbreviations apply to this standard. Hematoxylin-eosin staining H & E (haematoxylinandeosin)3 test the basic principlesA certain dose range of test substance orally administered to multiple groups of rodents. Tests usually require multiple exposure, exposure time can be Is 28d, subacute (90d) or chronic (1 year or longer). The method of this test guideline can also be used for acute neurotoxicity tests. Observation period Between neurotoxic effects caused by behavioral changes were evaluated, behavioral and (or) nervous system abnormalities were detected or qualitative. At the end of the experiment, yes Animals of both genders in each group were respectively perfused and fixed in situ, and histopathological examination was performed on the brain, spinal cord and peripheral nerves. Neither the in situ perfusion nor histopathology was performed when this test was used alone for neurotoxicity screening or to characterize neurotoxicity ......Tips & Frequently Asked Questions:Question 1: How long will the true-PDF of GB/T 21787-2008_English be delivered?Answer: Upon your order, we will start to translate GB/T 21787-2008_English as soon as possible, and keep you informed of the progress. The lead time is typically 1 ~ 3 working days. The lengthier the document the longer the lead time.Question 2: Can I share the purchased PDF of GB/T 21787-2008_English with my colleagues?Answer: Yes. The purchased PDF of GB/T 21787-2008_English will be deemed to be sold to your employer/organization who actually pays for it, including your colleagues and your employer's intranet.Question 3: Does the price include tax/VAT?Answer: Yes. 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