SN/T 5324.1-2020 PDF EnglishUS$155.00 · In stock · Download in 9 seconds
SN/T 5324.1-2020: Determination of oxcarbazepine, amitriptyline, sertraline, paroxetine and alimemazine in exported packaged drinking water and drinking natural mineral water-LC-MS/MS method Delivery: 9 seconds. True-PDF full-copy in English & invoice will be downloaded + auto-delivered via email. See step-by-step procedure Status: Valid
Similar standardsSN/T 5324.1-2020: Determination of oxcarbazepine, amitriptyline, sertraline, paroxetine and alimemazine in exported packaged drinking water and drinking natural mineral water-LC-MS/MS method---This is an excerpt. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.), auto-downloaded/delivered in 9 seconds, can be purchased online: https://www.ChineseStandard.net/PDF.aspx/SNT5324.1-2020 Determination of oxcarbazepine, amitriptyline, sertraline, paroxetine and alimemazine in exported packaged drinking water and drinking natural mineral water-LC-MS/MS method ForewordThis standard is drafted according to GB/T 1.1— 2020, GB/T 20001.4— 2015 and SN/T 0001— 2016. Please note that some of the contents of this document may involve patents. The issuing body of this document does not undertake the responsibility of identifying these patents. This standard is proposed by and is under the jurisdiction of General Administration of Customs, P. R. China. The standard is drafted by Beijing Customs District P.R.China, Beijing Academy of Food Science. The main drafters of this standard are Liang Nana, Feng Xin, Han Shen, Wang Peiyue, Gu Jin, Liu Ying, Cui Fengyun and Qi Heming. Determination of oxcarbazepine, amitriptyline, sertraline, paroxetine and alimemazine in exported packing drinking water and drinking natural mineral water-HPLC-MS/MS method1 ScopeThis standard specifies the determination method of oxcarbazepine, amitriptyline, sertraline, paroxetine and alimemazine, in purified drinking water, natural drinking mineral water and other drinking water by HPLC-MS/ MS method. This standard is applicable to the determination of oxcarbazepine, amitriptyline, sertraline, paroxetine and alimemazine in purified drinking water, natural drinking mineral water and other drinking water.2 Normative referenceThe following document is necessary for this standard. For dated reference, only dated editions shall apply to this standard. For undated references, the latest edition of the normative document referred to apply. GB/T 33087 Ultra pure water for instrumental analysis specification and test methods3 Terms and definitionsThere are no terms and definitions to be defined in this document.4 PrincipleThe compounds in samples are separated and determinated directly by HPLC-MS/MS. External standard method is used to determine the concentration of compounds.5 Regents and materialsUnless otherwise specified, all the regents used should be chromatographic grade. “Water” is the ultra pure water for instrumental analysis prescribed by GB/T 33087. 5.1 Formic acid. 5.2 Methanol. 5.3 Acetonitrile. 5.4 0.5% Formic acid water solution: 5 mL formic acid is dissolved in water and is fixed to 1 L. 5.5 20% Methanol water solution: 20 mL methanol is dissolved in water and is fixed to 100 mL. 5.6 Oxcarbazepine standards: C15H12N2O2, CAS 28721-07-5, purity: ≥ 99%. 5.7 Amitriptyline standards: C20H23N, CAS 50-48-6, purity: ≥ 99%. 5.8 Sertraline standards: C17H17Cl2N, CAS 79617-96-2, purity: ≥ 99%. 9SN/T 5324.1—2020 5.9 Paroxetine standards: C19H20FNO3, CAS 61869-08-7, purity: ≥ 99%. 5.10 Alimemazine standards: C18H22N2S, CAS 84-96-8, purity: ≥ 99%. 5.11 Standard stock solution: separately weigh 10 mg of oxcarbazepine (5.6), amitriptyline (5.7), sertraline (5.8), paroxetine (5.9)and alimemazine (5.10)(to the nearest 0.1 mg)and dissolve in a small amount of methanol, then fill to the volume of 10 mL using methanol. The concentration of each standard stock solution is 1 000 mg/L and stored at -18 ℃ . 5.12 Standard mix intermediate concentration solution: accurately pipette 0.1 mL of each standard stock solution (5.11). Fill to the volume of 10 mL using methanol. The concentration of each standard is 10 mg/L in the mix intermediate concentration solution and stored at 4 ℃ . 5.13 Standard mix working solution: Pipette adequate amount of standard mix intermediate concentration solution (5.11), dilute with 20% Methanol water solution (5.5)to prepare appropriate concentration standard working solutions before use. For oxcarbazepine, amitriptyline, sertraline, paroxetine and alimemazine, the concentration of these working solutions are 0.1, 0.5, 5, 20, 40 ng/mL.6 Apparatus and equipment6.1 High performance liquid chromatography: equipped with electric spray ion source (ESI). 6.2 Analytical balance: a sensitivity of 0.1 mg. 6.3 Centrifuge: ≥ 10 000 r/min. 6.4 Plugged plastic centrifuge tube: 2 mL. 6.5 Millipore filter film: 0.22 μm, nylon.7 Procedure7.1 Sample preparation Stand the water samples for 10 min after shaking it. Pipet a small amount of sample to the 2 mL plug plastic centrifuge tube (6.4)and centrifuge for 5 min at 12 000 r/min. Filter the supernatant with millipore filter film (6.5)for LC-MS/MS analysis. 7.2 Sample storage The test samples should be stored at 4 ℃ . 7.3 Determination 7.3.1 HPLC operation conditions HPLC operation conditions are as follows: a) Chromatographic column: HSS T3, 100 mm×2.1 mm(inner diameter), 1.7 μm or equivalent ； b) Injection volume: 5 μL ； c) Column temperature: 40 ℃ ； d) Flow rate: 0.35 mL/min ......Source: Above contents are excerpted from the full-copy PDF -- translated/reviewed by: www.ChineseStandard.net / Wayne Zheng et al. Tips & Frequently Asked Questions:Question 1: How long will the true-PDF of English version of SN/T 5324.1-2020 be delivered?Answer: The full copy PDF of English version of SN/T 5324.1-2020 can be downloaded in 9 seconds, and it will also be emailed to you in 9 seconds (double mechanisms to ensure the delivery reliably), with PDF-invoice.Question 2: Can I share the purchased PDF of SN/T 5324.1-2020_English with my colleagues?Answer: Yes. 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