SN/T 5324.3-2020 PDF EnglishUS$185.00 · In stock · Download in 9 seconds
SN/T 5324.3-2020: Determination of chlorpheniramine, cimetidine, promethazine, diphenhydramine, ranitidine, atenolol, propranolol and salbutamol in exported packaged water and drinking natural mineral water - LC-MS/MS method Delivery: 9 seconds. True-PDF full-copy in English & invoice will be downloaded + auto-delivered via email. See step-by-step procedure Status: Valid
Similar standardsSN/T 5324.3-2020: Determination of chlorpheniramine, cimetidine, promethazine, diphenhydramine, ranitidine, atenolol, propranolol and salbutamol in exported packaged water and drinking natural mineral water - LC-MS/MS method---This is an excerpt. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.), auto-downloaded/delivered in 9 seconds, can be purchased online: https://www.ChineseStandard.net/PDF.aspx/SNT5324.3-2020 Determination of chlorpheniramine, cimetidine, promethazine, diphenhydramine, ranitidine, atenolol, propranolol and salbutamol in exported packaged water and drinking natural mineral water — LC-MS/MS method ForewordPlease note that some of the contents of this document may involve patents. The issuing body of this document does not undertake the responsibility of identifying these patents. This standard is proposed by and is under the jurisdiction of General Administration of Customs, P. R. China. The standard is drafted by Beijing Customs District P.R.China, Beijing Academy of Food Science and Huangdao Customs District P.R.China, CPLA CDCP. The main drafters of this standard are Liu Ying, Liang Nana, Wang Peiyue, Han Shen, Qi Heming, Gu Jin, Cui Fengyun, Feng Xin, Guo Qinglong and Zhang Can. Determination of chlorpheniramine, cimetidine, promethazine, diphenhydramine, ranitidine, atenolol, propranolol and salbutamol in exported packaged water and drinking natural mineral water — LC-MS/MS method1 ScopeThis standard specifies the determination method of cimetidine, diphenhydramine, ranitidine, salbutamol, chlorpheniramine, promethazine, atenolol and propranolol in purified drinking water, natural drinking mineral water and other drinking water by liquid chromatography tandem mass spectrometry (LC-MS). This standard is applicable to the determination of cimetidine, diphenhydramine, ranitidine, salbutamol, chlorpheniramine, promethazine, atenolol and propranolol in purified drinking water, natural drinking mineral water and other drinking water.2 Normative referenceThe following document is necessary for this standard. For dated reference, only dated editions shall apply to this standard. For undated references, the latest edition of the normative document referred to apply. GB/T 33087 Ultra pure water for instrumental analysis specification and test methods.3 Terms and definitionsThere are no terms and definitions to be defined in this document.4 PrincipleThe PPCPs in samples are separated and determinated directly by LC-MS. External standard method is used to determine the concentration of the PPCPs.5 Regents and materialsUnless otherwise specified, all the regents used should be chromatographic grade. “Water” is the ultra pure water for instrumental analysis prescribed by GB/T 33087. 5.1 Formic acid. 5.2 Methanol. 5.3 Acetonitrile. 5.4 0.5% Formic acid water solution: dissolve 5 mL formic acid (5.1)in 1 000 mL water. 5.5 20% Methanol water solution: dissolve 20 mL methanol (5.2)in 100 mL water. 5.6 Atenolol reference standard : C14H22N2O3, CAS 29122-68-7, purity ≥ 99%. 5.7 Propranolol reference standard : C16H21NO2 ., CAS 525-66-6, purity ≥ 99%. 5.8 Salbutamol reference standard : C13H21NO3, CAS 18559-94-9, purity ≥ 99%. 5.9 Chlorpheniramine reference standard : C20H23ClN2O4, CAS 113-92-8, purity ≥ 99%. 5.10 Cimetidine reference standard : C10H16N6S, CAS 51481-61-9, purity ≥ 99%. 5.11 Promethazine reference standard : C17H20N2S, CAS 60-87-7, purity ≥ 99%. 5.12 Diphenhydramine reference standard : C17H21NO, CAS 58-73-1, purity ≥ 99%. 5.13 Ranitidine reference standard : C13H22N4O3S, CAS 66357-35-5, purity ≥ 99%. 5.14 Standard stock solution: separately weigh an adequate amount of reference standards (to the nearest 0.1 mg)and dissolve in a small amount of methanol (5.2), then fill to the volume of 10 mL using methanol. The concentration of each reference standard stock solution is 1000 mg/L. 5.15 Standard mix intermediate concentration solution: accurately pipette 0.1 mL of each standard stock solution (5.14). Fill to the volume of 10 mL using methanol (5.2). The concentration of each reference standard is 10 mg/L in the mix intermediate concentration solution. 5.16 Standard working solution: pipette adequate amount of standard mix intermediate concentration solution (5.15), dilute with 20% Methanol water solution (5.15)to prepare appropriate concentration standard working solutions. The concentration of these working solutions are 0.05 ng/mL, 0.1 ng/mL, 0.2 ng/mL,0.5 ng/mL, 2 ng/mL, 10 ng/mL,25 ng/mL,40 ng/mL.6 Apparatus and equipment6.1 High performance liquid chromatography: equipped with electric spray ion source (ESI). 6.2 Analytical balance: a sensitivity of 0.1 mg. 6.3 Centrifuge: ≥ 12 000 r/min. 6.4 Plug centrifuge tube: 2 mL. 6.5 Nylon millipore filter film: 0.22 μm.7 Procedure7.1 Sample preparation Mix the waters samples and pipet 2 mL sample to the centrifuge tube (6.4)and centrifuge for 5 min at 14 000 r/min. Filter the supernatant with Nylon millipore filter film (6.5)for LC-MS analysis. 7.2 Sample storage The test samples should be stored at 4℃ . ......Source: Above contents are excerpted from the full-copy PDF -- translated/reviewed by: www.ChineseStandard.net / Wayne Zheng et al. 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