GB/T 39650-2020 English PDF

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GB/T 39650-2020: Laboratory animal - Rules for nomenclature of mouse and rat strains
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Basic data

Standard ID: GB/T 39650-2020 (GB/T39650-2020)
Description (Translated English): Laboratory animal - Rules for nomenclature of mouse and rat strains
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: B44
Classification of International Standard: 65.020.30
Word Count Estimation: 14,166
Date of Issue: 2020-12-14
Date of Implementation: 2020-12-14
Quoted Standard: GB 14923
Regulation (derived from): National Standard Announcement No. 28 of 2020
Issuing agency(ies): State Administration for Market Regulation, China National Standardization Administration
Summary: This standard specifies the naming rules for experimental animal mouse and rat strains, including genetic classification of experimental animals, laboratory codes, inbred lines, inbred lines from multiple sources, homologous mutation inbred lines, and homologous inbred lines. The naming of crossed and separated inbred lines, the naming of closed groups (outbred groups) and hybrid groups. This standard applies to the naming of experimental animal mouse and rat strains.

GB/T 39650-2020: Laboratory animal - Rules for nomenclature of mouse and rat strains

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
(Laboratory animals Mouse and rat strain naming rules) ICS 65:020:30 B44 National Standards of People's Republic of China The naming rules of experimental animal mouse and rat strain 2020-12-14 release 2020-12-14 implementation State Administration for Market Regulation Issued by the National Standardization Management Committee

Foreword

This standard was drafted in accordance with the rules given in GB/T 1:1-2009: This standard was proposed and managed by the National Laboratory Animal Standardization Technical Committee (SAC/TC281): Drafting organizations of this standard: Institute of Medical Laboratory Animals, Chinese Academy of Medical Sciences, China Institute for Food and Drug Control, Shandong Laboratory Center for Medical Sciences, Xi’an Jiaotong University, Beijing Jishuitan Hospital, Laboratory Animal Center of China Center for Disease Control and Prevention, Shanghai Municipal Office of Fudan University Public Health Clinical Center, Occupational Hygiene and Poisoning Control Institute of Chinese Center for Disease Control and Prevention, Chinese Center for Disease Control and Prevention Health: The main drafters of this standard: Qin Chuan, Kong Qi, Yue Bingfei, Wei Qiang, Jin Dongqing, Liu Enqi, Zhao Danhui, Gao Hong, Lu Xuancheng, Zhou Xiaohui, Li Junyan, Wang Zhu, Shao Qiming, Xiang Zhiguang:

Introduction

There are many strains of experimental animals, mice and rats, which come from different laboratories all over the world, and their genetic backgrounds are quite different: Various mice and rats The standardized naming of strains is very important for cultivating and using these mice and rats worldwide: Especially between individuals of the same strain There is also the possibility of genetic drift, and the same strains cultivated in different laboratories should also be distinguished: This standard refers to the International Committee on Mouse Standardized Genetic Naming (InternationalCommitteeon Standardized Genetic NomenclatureforMice) formulated the "Mice and Rat Strain Naming Guidelines" (revised in January:2016): The naming rules of experimental animal mouse and rat strain

1 Scope

This standard specifies the naming rules for experimental animal mouse and rat strains, including the genetic classification of experimental animals, laboratory codes, and inbreeding Lines, multiple source inbred lines, homologous mutant inbred lines, homologous introduction inbred lines and isolated inbred lines, closed group (outbred group) and hybrid group Naming: This standard applies to the naming of experimental animal mouse and rat strains:

2 Normative references

The following documents are indispensable for the application of this document: For dated reference documents, only the dated version applies to this article Pieces: For undated references, the latest version (including all amendments) applies to this document: GB 14923 Laboratory Animals Genetic Quality Control of Mammals Laboratory Animals

3 Terms and definitions

The following terms and definitions defined in GB 14923 apply to this document: 3:1 Segregatinginbredstrains Through inbred breeding (usually sibling mating), each generation performs heterozygosity screening to isolate inbred lines to make a specific allele or mutation An inbred line that remains heterozygous: 3:2 Colaborative crossstrains; CC; GC Contains from 8 progenitor lines (A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, NZ/HILtJ, CAST/EiJ, PWK/ PhJ and WSB/EiJ) genetic genes: The funnel breeding strategy is adopted to incorporate all 8 ancestral lines into 3 breeding populations, and successive generations of brothers A multi-parental recombinant inbred line derived from the mating of sisters:

4 Classification of laboratory animal genetics

According to the different breeding methods and genetic characteristics of experimental animals, the classification is as follows: a) Inbred strains: 1) Recombinantinbredstrains, RI; 2) Recombinant congenicstrains, RC; 3) Colaborative crossstrains, CC, GC; 4) Mixed systems mixedinbredstrains, MI; 5) Advanced intercrosslines, AIL; 6) Homologous mutation inbred lines coisogenicinbredstrains; 7) Homologous introduction of inbred lines (same inbred lines) congenicinbredstrains; 8) Chromosome substitution system consomicstrainsorchromosomesubstitutionstrains; ......

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