GB/T 27831-2011 English PDF

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GB/T 27831-2011: Chemicals -- Genetic toxicology -- Test method of Saccharomyces cerevisiae gene mutation
Status: Valid

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 27831-2011	169	Add to Cart	3 days	Chemicals -- Genetic toxicology -- Test method of Saccharomyces cerevisiae gene mutation	Valid

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Basic data

Standard ID: GB/T 27831-2011 (GB/T27831-2011)
Description (Translated English): Chemicals -- Genetic toxicology -- Test method of Saccharomyces cerevisiae gene mutation
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: A80
Classification of International Standard: 13.300; 11.100
Word Count Estimation: 7,787
Date of Issue: 2011-12-30
Date of Implementation: 2012-08-01
Regulation (derived from): Announcement of Newly Approved National Standards No. 23 of 2011
Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China
Summary: This standard specifies the genotoxic chemicals Saccharomyces cerevisiae gene mutation test method terminology and definitions, test theory, test methods, test data and reports. This standard applies to detect genotoxic chemicals Saccharomyces cerevisiae gene mutations in eukaryotic microorganisms Saccharomyces cerevisiae forward or reverse mutation (base substitution and frameshift).

GB/T 27831-2011: Chemicals -- Genetic toxicology -- Test method of Saccharomyces cerevisiae gene mutation

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Chemicals. Genetic toxicology. Test method of Saccharomyces cerevisiae gene mutation ICS 13.300; 11.100 A80 National Standards of People's Republic of China Chemicals genotoxicity Saccharomyces cerevisiae gene mutation test method Issued on. 2011-12-30 2012-08-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released

Foreword

This standard was drafted in accordance with GB/T 1.1-2009 given rules. The Standard and Economy and Development (OECD) Chemicals Test Guidelines 480 (1986), "Genetic toxicity Saccharomyces cerevisiae gene mutation test Test "is consistent (in English) of technical content. This standard configuration and do the following editorial changes. --- Increasing the range a chapter; --- The original OECD480 the "essential information" as part of this standard 4.1.1.1; --- Change the unit of measure of legal units of measurement. This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points. This standard was drafted. Chinese Center for Disease Prevention and Control of Occupational Health and Poison Control, Guangxi Zhuang Autonomous Region Occupational Disease Prevention Research Institute, China Chemical Technology Development Center. The main drafters of this standard. Chen Xiaoqin, Chao-lin, Wang Xiaobing, Ai Wei Wu Lin Zheng. Chemicals genotoxicity Saccharomyces cerevisiae gene mutation test method

1 Scope

This standard specifies the terms and definitions, test principle, genotoxicity test methods for chemical Saccharomyces cerevisiae gene mutation test method Test data and reports. This standard is applicable to the detection of chemical genotoxicity S. cerevisiae gene mutation, eukaryotic microbes Saccharomyces projecting forward or reply Variable (base substitution and frameshift).

2 Terms and definitions

The following terms and definitions apply to this document. 2.1 Base substitution mutagens basesubstitutionmutagens Can cause DNA base changes (DeoxyribonucleicAcid, DNA) chemicals in reverse mutation test, this Base changes may occur in the genome of the primary mutation or second mutation site. 2.2 Frameshift mutagen frameshiftmutagens Caused by single or multiple base pairs to add or missing chemicals in DNA molecule.

3 Test principle

Saccharomyces cerevisiae haploid and diploid many strains can be used to detect gene mutations induced by the chemical factor product. In haploid strains forward mutation system, red colonies dependent mutant adenine (ade-1, ade-2) induced by the test substance is subjected, Adenine mutation relies on two white mutants. In the selection system may be employed canavanine and cycloheximide were resistant Induction. The most widely used and proven reverse mutation system includes haploid strains XV185-14C, this strain carries a nonsense mutation ochre Gene ade2-1, arg4-17, lys-1 and trp5-48, is through the base substitution mutations induced by specific sites or ochre suppressor gene mutation Generating reverse mutation. XV185-14C also carry his1-7 markers are missense mutations, mainly by second site mutations caused Back mutations. The hom3-10 marker is back mutations frameshift mutagen-induced. The only widely used diploid strain is D7, which is homozygous ilv1-92. Test Method 4 4.1 Test preparation 4.1.1 test substance 4.1.1.1 Basic information. a) solid, liquid, vapor or gaseous test substance; ......

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