GB/T 24800.3-2009 English PDFUS$189.00 · In stock
Delivery: <= 3 days. True-PDF full-copy in English will be manually translated and delivered via email. GB/T 24800.3-2009: Determination of spironolactone, benzoyl peroxide and tretinoin in cosmetics by high performance liquid chromatography method Status: Valid
Basic dataStandard ID: GB/T 24800.3-2009 (GB/T24800.3-2009)Description (Translated English): Determination of spironolactone, benzoyl peroxide and tretinoin in cosmetics by high performance liquid chromatography method Sector / Industry: National Standard (Recommended) Classification of Chinese Standard: Y42 Classification of International Standard: 71.100.70 Word Count Estimation: 8,833 Date of Issue: 2009-11-30 Date of Implementation: 2010-05-01 Regulation (derived from): National Standard Approval Announcement 2009 No.14 (Total No.154) Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China Summary: This standard specifies the cosmetics spironolactone, determination of benzoyl peroxide and tretinoin. This standard applies to skin care cosmetics in spironolactone, determination of benzoyl peroxide and tretinoin. GB/T 24800.3-2009: Determination of spironolactone, benzoyl peroxide and tretinoin in cosmetics by high performance liquid chromatography method---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order. Determination of spironolacton, benzoyl peroxide and tretinoin in cosmetics by high performance liquid chromatography method ICS 71.100.70 Y42 National Standards of People's Republic of China Cosmetics spironolactone, Determination of benzoyl peroxide and tretinoin High Performance Liquid Chromatography Posted 2009-11-30 2010-05-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released ForewordAppendix A of this standard is an informative annex. The standard proposed by China National Light Industry Council. This standard by the National Standardization Technical Committee of Fragrance Flavor and Cosmetic (SAC/TC257) centralized. This standard is drafted by. China Inspection and Quarantine Science Research Institute, Shanghai Daily Chemical Industry Research Institute, Shanghai Institute of spices. The main drafters of this standard. Wang Xing, Wu Ting Ma Qiang, Zhang, Xiao Haiqing, Shen Min, Kang Wei.IntroductionThe standard of the test substance spironolactone, Accutane is banned substances of "Hygienic Standard for Cosmetics" shall consist of not as a cosmetic raw Production of raw materials, component added to cosmetics. If technically unavoidable banned substances as impurities into cosmetics, then finished cosmetic products Should follow the "Hygienic Standard for Cosmetics" General requirements for cosmetics, that is, under normal and reasonably foreseeable conditions of use, the human body can not be Health hazards. At present, China has not yet specified the substance of limited value, the present standards, the determination of these substances in cosmetics only provide detection methods. Cosmetics spironolactone, Determination of benzoyl peroxide and tretinoin High Performance Liquid Chromatography1 ScopeThis standard specifies spironolactone, benzoyl peroxide and retinoic acid in cosmetic determination. This standard applies to skin care cosmetics spironolactone, benzoyl peroxide and retinoic acid determination. The standard for spironolactone, benzoyl peroxide detection limits were 2.5mg/kg, the limit of quantification are 5mg/kg; retinoic acid detection limits Of 1mg/kg, the limit of quantification of 2.5mg/kg. Principle 2 Methanol as solvent, ultrasonic extraction, centrifugation, 0.45μm organic membrane filter, the solution was injected with a diode array detector (DAD) liquid chromatography detection, external standard.3 Reagents and materialsUnless otherwise specified, reagents were of analytical grade. 3.1 Methanol. chromatographically pure. 3.2 spironolactone, purity of not less than 97%; benzoyl peroxide, purity of not less than 97%; retinoic acid, purity of not less than 99.9%. 3.3 spironolactone standard stock solution. Weigh accurately spironolactone 0.1g, accurate to 0.0001g, in 50mL beaker, add the amount dissolved in methanol After transferred to 100mL volumetric flask with methanol to volume, that was spironolactone solution concentration of 1000mg/L of standard stock solution. ice Box refrigerated. Benzoyl peroxide 3.4 standard stock solution. Weigh accurately benzoyl peroxide 0.1g, accurate to 0.0001g, in 50mL beaker, add After dissolved in methanol moved 100mL flask with methanol to volume, that was benzoyl peroxide solution concentration of 1000mg/L standard Quasi stock solution. Note. Due to the benzoyl peroxide water easily decomposed, to be using now each use. 3.5 retinoic acid standard stock solution. Weigh accurately retinoic acid 0.1g, accurate to 0.0001g, in 50mL beaker, add the amount dissolved in methanol After transferred to 100mL volumetric flask with methanol to volume, that was retinoic acid solution at a concentration of 1000mg/L of standard stock solution. ice Box dark refrigerated. Note. Because Accutane highly sensitive to light, see light easily decomposed metamorphic, the operation should be carried out under dark conditions. 3.6 standard mixed solution. Pipette 10mL of the three standard stock solution (3.3,3.4,3.5) to 100mL volumetric flask, respectively, with A Alcohol to volume, that was three substances are mixed standard stock solution 100mg/L of. 3.7 standard solution. methanol mixed solution of the above criteria (3.6) are formulated a series of concentrations of 1.0mg/L, 2.0mg/L, 5.0mg/L, 10mg/L, 20mg/L, 50mg/L, 100mg/L, 200mg/L of standard solution, using now. 3.8 0.1mol/L sodium hydroxide solution. Weigh sodium hydroxide 0.4g, accurate to 0.001g, in 50mL beaker, dissolved in water Transferred to a 100mL volumetric flask, add water to volume, that was 0.1mol/L sodium hydroxide solution. 3.9 0.025mol/L sodium dihydrogen phosphate solution (pH6.5). Weigh sodium dihydrogen phosphate (NaH2PO4 · 2H2O) 3.9g, accurate to 0.001g, in 50mL beaker, dissolved in water and transferred to 1000mL volumetric flask with water to volume, and mix to obtain 0.025mol/L of sodium dihydrogen phosphate. PH is adjusted to 6.5 with 0.1mol/L sodium hydroxide solution (3.8). ......Tips & Frequently Asked Questions:Question 1: How long will the true-PDF of GB/T 24800.3-2009_English be delivered?Answer: Upon your order, we will start to translate GB/T 24800.3-2009_English as soon as possible, and keep you informed of the progress. The lead time is typically 1 ~ 3 working days. The lengthier the document the longer the lead time.Question 2: Can I share the purchased PDF of GB/T 24800.3-2009_English with my colleagues?Answer: Yes. The purchased PDF of GB/T 24800.3-2009_English will be deemed to be sold to your employer/organization who actually pays for it, including your colleagues and your employer's intranet.Question 3: Does the price include tax/VAT?Answer: Yes. 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