GB/T 21852-2008 English PDF

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GB/T 21852-2008: Testing of chemicals -- Partition coefficient (n-octanol/water) -- High performance liquid chromatography (HPLC) method
Status: Valid

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 21852-2008	254	Add to Cart	3 days	Testing of chemicals -- Partition coefficient (n-octanol/water) -- High performance liquid chromatography (HPLC) method	Valid

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Basic data

Standard ID: GB/T 21852-2008 (GB/T21852-2008)
Description (Translated English): Testing of chemicals -- Partition coefficient (n-octanol/water) -- High performance liquid chromatography (HPLC) method
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: A80
Classification of International Standard: 13.300
Word Count Estimation: 13,117
Date of Issue: 2008-05-12
Date of Implementation: 2008-09-01
Adopted Standard: OECD No.117-2004, IDT
Regulation (derived from): Announcement of Newly Approved National Standards 2008 No. 8 (No. 121 overall)
Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China
Summary: This standard specifies the chemical partition coefficient HPLC testing method outlined, test systems, test procedures, quality assurance and quality control, data and reports. This standard applies to the determination of a value of 0 to 6 1gPow chemicals within the scope partition coefficient [ 1 ], [ 2 ], [ 3 ], [ 4 ], [ 5 ], a special case can also be extended to 1gPow 6 to 10 chemicals. This standard does not apply to acids, bases, metal complexes, compounds that react with the eluent and surfactants.

GB/T 21852-2008: Testing of chemicals -- Partition coefficient (n-octanol/water) -- High performance liquid chromatography (HPLC) method

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Testing of chemicals. Partition coefficient (n-octanol/water). High performance liquid chromatography (HPLC) method ICS 13.300 A80 National Standards of People's Republic of China Chemical Distribution coefficient (n-octanol - water) HPLC test Posted 2008-05-12 2008-09-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released

Foreword

This standard is identical with the Organisation for Economic Co-operation and Development Guidelines for Testing of Chemicals No. 117 (2004), "partition coefficient (octanol - water). High performance liquid chromatography "(in English). The editorial changes made the following standard. --- The original text of the recommended reference substances added to adjust the table in Appendix A; --- The units of measurement to our legal units of measurement. The Standard Appendix A, Appendix B is an informative annex. This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points. This standard is drafted by. Environmental Protection Department of Chemical Registration Center. Participated in the drafting of this standard. Shenyang Research Institute of Chemical Safety Evaluation Center, Ministry of Environmental Protection, Nanjing Institute of Environmental Sciences, Shanghai ring Habitat Research Institute, Chinese Academy of Environmental Sciences. The main drafters of this standard. Cheng Ji, Liu Chun new, Ge Haihong, Cailei Ming, Li Ying, Yang Conde, root Shen Xiang, Li Handong. This standard was first formulated. Chemical Distribution coefficient (n-octanol - water) HPLC test

1 Scope

This standard specifies the chemical distribution coefficient (n-octanol - water) method of high performance liquid chromatography test summary, test systems, test drive Order, quality assurance and quality control, data and reports. This standard applies to the determination of the range is 0 to 6 lgPow chemicals distribution coefficient [1], [2], [3], [4], [5], special circumstances may be LgPow was extended to 6 to 10 chemicals. This standard does not apply to compound strong acids, bases, metal complexes, react with the eluent Substance and a surfactant.

2 Terms and definitions

The following terms and definitions apply to this standard. 2.1 Than the equilibrium concentration of the test substance reached the immiscible two-phase medium. 2.2 Test substance in n-octanol - reach equilibrium water concentration ratio of the two-phase medium when to Pow expressed. Pow dimensionless, generally for 10 Logarithm (lgPow) represented.

3 Methods Summary

3.1 Principle RP-HPLC is the process of separating the analytical column. After the test material into the column, with mobile phase solvent flow Partitioned between phase and the hydrocarbon stationary phase. Compounds in the column Retention Time and hydrocarbons - water partition coefficient is proportional to the first wash hydrophilic compound Off, after lipophilic compounds eluted. Retention time in the capacity factor k represented, see (1). (1) Where. This method does not require a quantitative analysis method, the determination of the retention time values \u200b\u200bonly. Test substance octanol - water partition coefficient can be measured by testing their capacity factor k, substituted into the formula (2) is calculated. lgPow = Rao + Chou × lg k (2) Where. Pow --- octanol - water partition coefficient; A, b --- linear regression coefficients. (2) by the lgPow reference material (n-octanol - water partition coefficient) of its lg k (capacity factor) for the resulting linear regression. For ionic compounds which can be measured the partition coefficient of non-ionic form (free acid or free base) under suitable test medium for the case When the buffer. For free acid buffer pH below pKa; for free base, buffer pH higher than pKa. In addition, pH-metric method can also be used to determine the partition coefficient of the ionic compound [6]. If lgPow value or classification for environmental hazards ......

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