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Delivery: <= 4 days. True-PDF full-copy in English will be manually translated and delivered via email. GB/T 21826-2008: Chemicals -- Test method of acute oral toxicity -- Up and down procedure (UDP) Status: Valid
Basic dataStandard ID: GB/T 21826-2008 (GB/T21826-2008)Description (Translated English): Chemicals -- Test method of acute oral toxicity -- Up and down procedure (UDP) Sector / Industry: National Standard (Recommended) Classification of Chinese Standard: A80 Classification of International Standard: 13.300; 11.100 Word Count Estimation: 24,279 Date of Issue: 2008-05-12 Date of Implementation: 2008-09-01 Quoted Standard: ASTM E1163-1987 Adopted Standard: OECD No.425-2006, IDT Regulation (derived from): Announcement of Newly Approved National Standards 2008 No. 8 (No. 121 overall) Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China Summary: This standard specifies the chemical acute oral toxicity test methods Up and down the scope of law, terms and definitions, test principles, test methods, data and reports. This standard applies to chemicals acute oral toxicity test methods Up and down France. GB/T 21826-2008: Chemicals -- Test method of acute oral toxicity -- Up and down procedure (UDP)---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.Chemicals. Test method of acute oral toxicity. Up and down procedure (UDP) ICS 13.300; 11.100 A80 National Standards of People's Republic of China Chemicals acute oral toxicity test method Up and down - dose (UDP) Posted 2008-05-12 2008-09-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released ForewordThis standard is identical with the Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 425 (2006), "The acute oral toxicity --- Up and down method of dose (UDP) "(in English). This standard made the following editorial changes. --- Press on the text format GB/T 1.1-2000 made editorial changes; --- Increasing the "OECD Introduction" section, the OECD Chemical Test Method No. Test Notes 425 Part included "OECD Introduction" of; --- To increase the "scope" chapter; --- OECD Chemical Test Method No. 425 Appendix (definitions) section of this standard to Chapter 2, "Terms and Definitions"; --- Remove the OECD Chemical Test Method No. 425 "References" parts. The Standard Appendix A and Appendix C is a normative appendix, Appendix B is an informative annex. This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points. This standard is drafted by. SZCIQ. Participated in the drafting of this standard. Guangdong CIQ. The main drafters of this standard. Zhihong, Li Bin, Liu Li, Liu Xianjie, Chen Xiangyang, Wang Hongju, Chen Meirong, Lizhi Ru, Liu Yuhong, Chen Qiang, Xuchong Hui. OECD IntroductionIntroductionOrganisation for Economic Co-operation and Development (OECD) Chemicals testing guidelines in accordance with scientific progress or changing assessment practices carried out periodic assessment On. Up and down dose method originally proposed by Dixon and Mood. In 1985, Bruce recommends the use of more or dose method (UDP) Determination of the acute toxicity of chemicals. Up and down LD50 dose experimental design method has several times changed. This guide is based on the proposed Bruce Test method This test method was adopted in 1987 ASTM, and revised in 1990. Published in 1995 using UDP, Biography EC LD50 test methods and fixed dose method (FDP, OECD Test Guidelines 420) The results obtained by the three methods. And from Dixon Mood papers early start, a lot of research using these methods were optimized conditions have emerged in the application of biological and thesis. based on Several recommendations of the 1999 Expert Meeting on methods for the following reasons need timely amendments. i) the use of internationally coordinated LD50 cut-off value Have reached a consensus on the classification of chemicals issues; i) test is generally considered one sex (usually the female) is sufficient; ii) To make single Site assessment more meaningful, the need for confidence intervals (CI) were evaluated. This guidance given in the test program is designed to measure the minimum amount of animal acute oral toxicity of chemicals. In addition to evaluating LD50 And confidence intervals, tests were also observed toxicity performance, the revised Test Guidelines 420, 430 and 425 are performed simultaneously. In the guidance document oral toxicity test section you can choose the most appropriate test method for testing a specific target. This means Southern file also includes additional information on the implementation of 425 guidance documents and interpretation. Test Conditions Laboratory should consider all available information on the test substance prior to conducting the test. Information includes test substance identification and chemical structure Structurally related substances toxicological or similar compounds; any in vitro or in vivo toxicity test results of the test substance; physicochemical properties; structure Data; also includes a test substance is expected to use the information. This information helps to infer human health and environmental protection in terms of the relevance of the test, and the other Outside also helps select the appropriate starting dose. This method allows an assessment of the LD50 is provided with a confidence interval, according to the classification and labeling of chemicals Globally Harmonized System of acute toxicity Chemicals classification criteria, based on the results of these tests can be rated and classified material. When there is no information on LD50 and dose - response curve slope when the preliminary evaluation, it is recommended to use computer simulation results, from 175mg/kg near the beginning, the use of semi-logarithmic unit dose (corresponding to a dose progression factor 3.2) can produce the best results. If the matter Quality may be highly toxic, the starting dose should be corrected. Semi-logarithmic spacing can be more efficient use of animals, increasing the LD50 prediction accuracy. Since this method of starting dose biased, so be sure to select the initial dose below the estimated LD50. However And, similar to other acute toxicity method, large variability of chemicals (eg, low dose - response curve slope) or will assess the lethal dose Introducing bias, LD50 have a large statistical error. The main part of the test to stop this rule can be corrected without stopping rule Experimental observation is merely a fixed number (see 5.3.2.2.3), to assess its accuracy is critical. This method is easier to apply to a day after exposure to substances causing death within two days or. Does not apply to post-exposure may occur delayed dead Death (5d or above) substances. The establishment of a computer test sequence and provides a final evaluation, simplifies the calculation of the animals one by one. If you know the test substance at a dose of corrosive or severely irritating behavior resulted in significant pain, you do not need to conduct the trial. Should be humane The animals were sacrificed or obvious pain dying or showing severe and persistent pain in animals, it should be the same as the test results in experimental animals died Explained. Limited test can be effectively applied to the low toxicity of chemicals. Chemicals acute oral toxicity test method Up and down - dose (UDP)1 ScopeThis standard specifies the range of chemicals the acute oral toxicity test method --- more or dose method (UDP), the terms and definitions, test Test principle, test methods, data and reports. This standard applies to chemicals of acute oral toxicity test method --- more or dose method (UDP).2 Normative referencesThe following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard. ASTME1163-1987 Test Method Evaluation Acute Oral rodenticides3 Terms and DefinitionsThe following terms and definitions apply to this standard. 3.1 The test was within 24h to test animals exposed orally once or more deleterious effects after oral exposure arising. 3.2 Within 48h test animals appear not cause death or near-death state, but the deaths occurred during the period of observation 14d. 3.3 The amount of administration of the test substance during the test animals were exposed to the test, the quality of (g, mg) expressed in animal or per unit weight of test substance Expressed in the amount (e.g., mg/kg). 3.4 Sometimes referred to as a stepping dose factor. Means that when an animal alive under an animal increases exponentially dose (ie, dose series); or when When an animal dies, the animal under a double dose reduction. Dose series recommended that factor 1/(estimated dose - response curve slope) of number. The default dose progression factor of 3.2, that is opposed to the number of 0.5 or 1/2. 3.5 Chemicals Globally Harmonized System of Classification and Labeling, the Organization for Economic Cooperation and Development (OECD) (human health and the environment), the United Nations dangerous Joint Committee of Experts on the transport of goods (UNCETDG) (physicochemical properties) and the International Labour Organization (ILO) (transport of dangerous goods information transfer) of action. And with the inter-agency planning sound management of chemicals Organization (IOMC) coordinated. 3.6 Before the next scheduled observation period appear moribund state or death. Performance near death state rodent convulsions, lateral, reclining And tremor (details visible humanely sacrificed end guidance document). ......Tips & Frequently Asked Questions:Question 1: How long will the true-PDF of GB/T 21826-2008_English be delivered?Answer: Upon your order, we will start to translate GB/T 21826-2008_English as soon as possible, and keep you informed of the progress. The lead time is typically 2 ~ 4 working days. The lengthier the document the longer the lead time.Question 2: Can I share the purchased PDF of GB/T 21826-2008_English with my colleagues?Answer: Yes. The purchased PDF of GB/T 21826-2008_English will be deemed to be sold to your employer/organization who actually pays for it, including your colleagues and your employer's intranet.Question 3: Does the price include tax/VAT?Answer: Yes. 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