GB/T 21606-2022 English PDF

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GB/T 21606-2022: Chemicals - Test method of acute dermal toxicity
Status: Valid

GB/T 21606: Historical versions

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 21606-2022	289	Add to Cart	3 days	Chemicals - Test method of acute dermal toxicity	Valid
GB/T 21606-2008	879	Add to Cart	4 days	Test method of acute dermal toxicity for chemicals	Obsolete

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Basic data

Standard ID: GB/T 21606-2022 (GB/T21606-2022)
Description (Translated English): Chemicals - Test method of acute dermal toxicity
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: A80
Word Count Estimation: 14,117
Issuing agency(ies): State Administration for Market Regulation, China National Standardization Administration

GB/T 21606-2008: Test method of acute dermal toxicity for chemicals

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Test method of acute dermal toxicity for chemicals ICS 13.300; 11.100 A80 National Standards of People's Republic of China Chemicals acute dermal toxicity test methods Posted 2008-04-01 2008-09-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released

Foreword

This revised standard adopts the United Nations Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 402 "Acute dermal toxicity test Test "(1992.7) (in English). This standard OECD Chemicals Test Method No. 402 compared with the following differences. --- To OECD Chemicals Test Method No. 402 were editorial changes; --- Increased the preamble; --- Added Appendix section. The Standard Appendix B, Appendix D normative appendix; Appendix A, Appendix C is informative appendix. This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points. This standard is drafted by. China Center for Disease Control and Prevention of Occupational Health and Poison Control. Participated in the drafting of this standard. Tianjin Inspection and Quarantine Institute of Science and Technology, Henan Province Occupational Disease Prevention Hospital. The main drafters of this standard. Ai Wei Wu, Chao-lin, HOU powder Xia Lin Zheng, Sun Jinxiu, LI Shuang, Zhang Yuan, in Chi Rui, Lining Tao, Tao. Chemicals acute dermal toxicity test methods

1 Scope

This standard specifies the test object, test the basic principles, test methods, evaluation of the test results, the test animals reported acute dermal toxicity test Reporting and interpretation of results. This standard applies to the evaluation of acute dermal toxicity of chemicals.

2 Terms and definitions

2.1 Test samples once or several times within 24h after the health effects of skin damage arising from exposure. 2.2 Once or several times within 24h dermal exposure test sample, the test animals caused by the occurrence probability of death of 50% of the dose, in a unit body Re-acceptance of the quality of the test sample [mg/kg or g/kg] to represent. 2.3 Chemical poisons represent the relationship between the dose of a particular group in the incidence of mass effect.

3 test purposes

Determining whether the test sample is absorbed through the skin and short-term percutaneous exposure arising from acute toxicity and strength, and to determine the subacute (slowly) Percutaneous dose toxicity and other tests designed to provide experimental basis.

4 Test the basic principles

Before the test, the first test site to remove the animal's coat. The experimental animals were divided into several dose groups receiving different doses applied Test samples, and then observed in experimental animals toxic reactions and death, calculated LD50. The test animals died in the gross anatomy and pathology Histological examination of the surviving animals at the end of the test should also be done gross anatomy. Note that the test sample excluded due to local skin irritation or rot Erosion effects caused by systemic effects.

5 Test methods

5.1 test sample Insoluble or poorly soluble or particulate solid test sample to be milled through 100 mesh screen. With the amount of non-toxic and non-irritating excipient mix, in order to maintain Contacting the sample with a test certificate good skin. Commonly used excipients are water, vegetable oils, vaseline, lanolin and the like. Liquid test sample is generally not Will be diluted, it can be directly used dope test. 5.2 Experimental Animals Preferred rats, rabbits or guinea pigs can also be used. Experimental animals were weight range requirements. rat 200g ~ 300g, guinea pigs 350g ~ 450g, rabbits 2000g ~ 3000g. During the test, in order to avoid scratching each other experimental animals, should be adopted in a single cage feeding. Before the test, 24h, in the back of the animal to the hair on both sides of the midline, carefully check the skin, requiring intact, so as not to alter the permeability of the skin. To the gross area of \u200b\u200bnot less than 10% of the body surface area of \u200b\u200bexperimental animals. Values \u200b\u200band calculation methods of various types of animals, body surface area, see Appendix D. ......

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