GB/T 21603-2008 English PDFUS$199.00 ยท In stock
Delivery: <= 2 days. True-PDF full-copy in English will be manually translated and delivered via email. GB/T 21603-2008: Chemicals -- Test method of acute oral toxicity Status: Obsolete
Basic dataStandard ID: GB/T 21603-2008 (GB/T21603-2008)Description (Translated English): Chemicals -- Test method of acute oral toxicity Sector / Industry: National Standard (Recommended) Classification of Chinese Standard: A80 Classification of International Standard: 13.300; 11.100 Word Count Estimation: 5,567 Date of Issue: 2008-04-01 Date of Implementation: 2008-09-01 Quoted Standard: GB/T 21605-2008 Adopted Standard: OECD No.401-1987, MOD Regulation (derived from): Announcement of Newly Approved National Standards No. 5, 2008 (No. 118 overall) Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China Summary: This standard specifies the animals of chemicals acute oral toxicity test methods, test procedures and test results. This standard applies to chemicals Determination of acute oral toxicity. GB/T 21603-2008: Chemicals -- Test method of acute oral toxicity---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.Chemicals. Test method of acute oral toxicity ICS 13.300; 11.100 A80 National Standards of People's Republic of China Chemicals acute oral toxicity test method Posted 2008-04-01 2008-09-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released Book ` ForewordThis revised standard adopts the United Nations Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 401 "acute oral toxicity test Test "(1987). This standard OECD Chemicals Test Method No. 401, the following differences. --- To OECD Chemicals Test Method No. 401 were editorial changes; --- Increase the preamble. This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points. This standard is drafted by. Tianjin Inspection and Quarantine Institute of Science and Technology. Participated in the drafting of this standard. Tianjin Inspection and Quarantine Institute of Science and Technology, Jiangnan University, China Chemical standardization, Tianjin Entry Inspection and Quarantine Bureau, Chinese Center for Disease Prevention and Control of Occupational Health and Poison Control. The main drafters. Zhang Yuan, Wangli Bing, Zhao Zhuo, Xu came, Wang Xiaobing, in Chi Rui, Li Chaoyang. This standard was first formulated. Chemicals acute oral toxicity test method1 ScopeThis standard specifies the chemical animal acute oral toxicity test of the test methods, test procedures and test results. This standard applies to the determination of acute oral toxicity of chemicals.2 Normative referencesThe following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard. GB/T 21605-2008 Chemical Acute inhalation toxicity testing The Ministry of Health "toxic chemicals identified technical specifications" (2005)3 Terms and DefinitionsThe following terms and definitions apply to this standard. 3.1 Once or several times in the 24h of experimental animals after oral administration of the test sample, animals health damage effect in the short term. 3.2 After orally once or several times within 24h oral administration of the test sample, causing the death of half of the population of experimental animals poison statistical agent the amount. Accept the test sample per body mass (mg/kg or g/kg) is represented. 3.3 Chemical poisons represent the relationship between the dose of a particular group in the incidence of mass effect. Test Method 4 4.1 Processing of the test sample The test sample should be dissolved or suspended in a suitable vehicle, we recommend preferred vegetable oil or water as a solvent, may also consider the use of other excipients (E.g., carboxymethyl cellulose, gelatin, starch, etc.) were prepared at a suspension; can not be formulated as a suspension, it may be formulated into other forms (e.g. a paste); not The solvent can be employed in organic chemistry has significant toxicity, such as the use of toxic solvents should be single-vehicle control group was observed. 4.2 Experimental Animals Preferred healthy adult mice (18g ~ 22g) and rats (180g ~ 220g), can also be used other sensitive animals. Sex with animals The difference between the weight of the individual shall not exceed 20% of the average weight. Before the test animals to adapt to the 3d ~ 5d time at least in the test environment. 4.3 dose design According to the requirements of the selected method, it should be located 4 to 5 dose groups, in principle, each animal is usually 10, male and female. Each dose group From size to accommodate the size of toxicity and death is appropriate, usually in large groups, and a lesser amount from the pre-test animals. If the toxicity of the test sample Low, may also limit the maximum method, which uses 20 animals (male and female), using 5000mg/kg dose, not resulting in death of the animal can be No multiple doses of acute oral toxicity test. ......Tips & Frequently Asked Questions:Question 1: How long will the true-PDF of GB/T 21603-2008_English be delivered?Answer: Upon your order, we will start to translate GB/T 21603-2008_English as soon as possible, and keep you informed of the progress. The lead time is typically 1 ~ 2 working days. 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