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GB 30000.23-2013: Rules for classification and labelling of chemical - Part 23: Carcinogenicity Delivery: 9 seconds. True-PDF full-copy in English & invoice will be downloaded + auto-delivered via email. See step-by-step procedure Status: Valid
Similar standardsGB 30000.23-2013: Rules for classification and labelling of chemical - Part 23: Carcinogenicity---This is an excerpt. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.), auto-downloaded/delivered in 9 seconds, can be purchased online: https://www.ChineseStandard.net/PDF.aspx/GB30000.23-2013GB NATIONAL STANDARD OF THE PEOPLE’S REPUBLIC OF CHINA ICS 13.300 A 80 Replacing GB 20597-2006 Rules for classification and labelling of chemicals - Part 23. Carcinogenicity Issued on: OCTOBER 10, 2013 Implemented on: NOVEMBER 1, 2014 Issued by. General Administration of Quality Supervision, Inspection and Quarantine; Standardization Administration Committee. Table of ContentsForeword ... 3 1 Scope ... 6 2 Normative references ... 6 3 Terms and definitions ... 6 4 Classification criteria ... 7 5 Decision logic and guidance ... 12 6 Labels ... 13 Annex A ... 16 Annex B ... 18 Annex C ... 19 Annex D ... 20 Annex E ... 23 References ... 24ForewordChapter 4 and Chapter 6 of this Part are mandatory. The rest are recommended. The expected structure of "Rules for classification and labelling of chemicals" and the national standards to be replaced are as follows. - Part 1. General rules (replacing GB 13690-2009); - Part 2. Explosives (replacing GB 20576-2006); - Part 3. Flammable gases (replacing GB 20577-2006); - Part 4. Aerosols (replacing GB 20578-2006); - Part 5. Oxidizing gases (replacing GB 20579-2006); - Part 6. Gases under pressure (replacing GB 20580-2006); - Part 7. Flammable liquids (replacing GB 20581-2006); - Part 8. Flammable solids (replacing GB 20582-2006). - Part 9. Self-reactive substances and mixtures (replacing GB 20583-2006); - Part 10. Pyrophoric liquids (replacing GB 20585-2006); - Part 11. Pyrophoric solids (replacing GB 20586-2006); - Part 12. Self-heating substances and mixtures (replacing GB 20584-2006); - Part 13. Substances and mixtures which, in contact with water, emit flammable gases (replacing GB 20587-2006); - Part 14. Oxidizing liquids (replacing GB 20589-2006); - Part 15. Oxidizing solids (replacing GB 20590-2006); - Part 16. Organic peroxides (replacing GB 20591-2006); - Part 17. Corrosive to metals (replacing GB 20588-2006). - Part 18. Acute toxicity (replacing GB 20592-2006); - Part 19. Skin corrosion/irritation (replacing GB 20593-2006); - Part 20. Serious eye damage/eye irritation (replacing GB 20594 a 2006); - Part 21. Respiratory or skin sensitization (replacing GB 20595-2006); - Part 22. Germ cell mutagenicity (replacing GB 20596-2006); - Part 23. Carcinogenicity (replacing GB 20597-2006); - Part 24. Reproductive toxicity (replacing GB 20598-2006); - Part 25. Specific target organ toxicity. Single exposure (replacing GB 20599-2006); - Part 26. Specific target organ toxicity. Repeated exposure (replacing GB 20601-2006); - Part 27. Aspiration hazard; - Part 28. Hazardous to the aquatic environment (replacing GB 20602-2006); - Part 29. Hazardous to the ozone layer; - Part 30. Work safety warning signs. This Part is Part 23 of GB 30000. This Part was drafted in accordance with the rules given in GB/T 1.1-2009. This Part shall replace GB 20597-2006 "Safety rules for classification, precautionary labelling and precautionary statements of chemicals - Carcinogenicity". Compared with GB 20597-2006, the major technical content changes are as follows. - MODIFY the standard name. The Chinese name is changed to "Rules for classification and labelling of chemicals. Part 23. Carcinogenicity". The English name is changed to "Rules for classification and labelling of chemicals. Part 23. Carcinogenicity"; - MODIFY the content of Chapter 1 "Scope". The "warning label" is changed to "label". DELETE "precautionary statements"; - MODIFY the introductory phrase in Chapter 2 "Normative references"; ADD GB 13690 and GB/T 16483 as reference documents; - ADD the introductory phrase in Chapter 3 "Terms and definitions". - MODIFY the format of Table 2 according to GHS (fourth revised edition); Rules for classification and labelling of chemicals - Part 23. Carcinogenicity1 ScopeThis Part of GB 30000 specifies the terms and definitions, classification criteria, decision logic and guidance, and labels of chemicals with carcinogenicity. This Part is applicable to the classification and labelling of chemicals with carcinogenicity according to "Globally Harmonized System of Classification and Labelling of Chemicals" (hereafter referred to as GHS) of the United Nations.2 Normative referencesThe following documents are essential for the application of this document. For dated references, only the dated editions apply to this document. For undated references, the latest editions (including all corrections) of the referenced documents apply to this document. GB 13690 General rules for classification and hazard communication of chemicals GB/T 16483 Safety data sheet for chemical products - Content and order of sections United Nations “Recommendations on the transport of dangerous goods - Model regulation” (Seventeenth revised edition) United Nations "Globally Harmonized System of Classification and Labelling of Chemicals" (Fourth revised edition)3 Terms and definitionsThose defined in GB 13690 AND the following terms and definitions apply to this document. 3.1 Carcinogen A substance or a mixture which induces cancer or increases its incidence. Substances and mixtures which have induced benign and malignant tumours additional considerations, such evidence may be from either limited evidence of carcinogenicity in human studies or from limited evidence of carcinogenicity in animal studies. Classification. Category 2 Carcinogen 4.2.2 Carcinogen classification is made on the basis of evidence from reliable and acceptable methods, and is intended to be used for substances which have an intrinsic property to produce such toxic effects. The evaluations should be based on all existing data, peer-reviewed published studies and additional data accepted by regulatory agencies. 4.2.3 Carcinogen classification is a one-step, criterion-based process that involves two interrelated determinations. evaluations of strength of evidence and consideration of all other relevant information to place substances with human cancer potential into hazard categories. 4.2.4 Strength of evidence involves the enumeration of tumours in human and animal studies and determination of their level of statistical significance. Sufficient human evidence demonstrates causality between human exposure and the development of cancer, whereas sufficient evidence in animals shows a causal relationship between the agent and an increased incidence of tumours. Limited evidence in humans is demonstrated by a positive association between exposure and cancer, but a causal relationship cannot be stated. Limited evidence in animals is provided when data suggest a carcinogenic effect, but are less than sufficient. The terms “sufficient” and “limited” are used here as they have been defined by the International Agency for Research on Cancer (IARC) and are outlined in 5.1. 4.2.5 Additional considerations (weight of evidence). 4.2.5.1 The factors can be viewed as either increasing or decreasing the level of concern for human carcinogenicity. The relative emphasis accorded to each factor depends upon the amount and coherence of evidence bearing on each. Generally there is a requirement for more complete information to decrease than to increase the level of concern. Additional considerations should be used in evaluating the tumour findings and the other factors in a case-by-case manner. 4.2.5.2 Some important factors which may be taken into consideration, when assessing the overall level of concern are. - Tumour type and background incidence; - Multisite responses; - Progression of lesions to malignancy; - Reduced tumour latency. Additional factors which may increase or decrease the level of concern include. - Whether responses are in single or both sexes; - Whether responses are in a single species or several species; - Structural similarity or not to a substance(s) for which there is good evidence of carcinogenicity; - Routes of exposure; - Comparison of absorption, distribution, metabolism and excretion between test animals and humans; - The possibility of a confounding effect of excessive toxicity at test doses; - Mode of action and its relevance for humans, such as mutagenicity, cytotoxicity with growth stimulation, mitogenesis, immunosuppression. 4.2.5.3 Mutagenicity. It is recognized that genetic events are central in the overall process of cancer development. Therefore evidence of mutagenic activity in vivo may indicate that a substance has a potential for carcinogenic effect... ......Source: Above contents are excerpted from the full-copy PDF -- translated/reviewed by: www.ChineseStandard.net / Wayne Zheng et al. Tips & Frequently Asked Questions:Question 1: How long will the true-PDF of English version of GB 30000.23-2013 be delivered?Answer: The full copy PDF of English version of GB 30000.23-2013 can be downloaded in 9 seconds, and it will also be emailed to you in 9 seconds (double mechanisms to ensure the delivery reliably), with PDF-invoice.Question 2: Can I share the purchased PDF of GB 30000.23-2013_English with my colleagues?Answer: Yes. The purchased PDF of GB 30000.23-2013_English will be deemed to be sold to your employer/organization who actually paid for it, including your colleagues and your employer's intranet.Question 3: Does the price include tax/VAT?Answer: Yes. 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