GB/T 45213-2025 English PDFUS$279.00 · In stock
Delivery: <= 3 days. True-PDF full-copy in English will be manually translated and delivered via email. GB/T 45213-2025: Determiantion of amylocaine, butanilicaine and pramocaine in cosmetics - Liquid chromatography-tandem mass spectrometry Status: Valid
Basic dataStandard ID: GB/T 45213-2025 (GB/T45213-2025)Description (Translated English): Determiantion of amylocaine, butanilicaine and pramocaine in cosmetics - Liquid chromatography-tandem mass spectrometry Sector / Industry: National Standard (Recommended) Classification of Chinese Standard: Y42 Classification of International Standard: 71.100.70 Word Count Estimation: 14,199 Date of Issue: 2025-01-24 Date of Implementation: 2025-08-01 Issuing agency(ies): State Administration for Market Regulation, China National Standardization Administration GB/T 45213-2025: Determiantion of amylocaine, butanilicaine and pramocaine in cosmetics - Liquid chromatography-tandem mass spectrometry---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order. ICS 71.100.70 CCSY42 National Standard of the People's Republic of China Amicaine, Butancaine, and Pramocaine in Cosmetics Determination of HPLC-MS/MS Released on 2025-01-24 2025-08-01 Implementation State Administration for Market Regulation The National Standardization Administration issued ForewordThis document is in accordance with the provisions of GB/T 1.1-2020 "Guidelines for standardization work Part 1.Structure and drafting rules for standardization documents" Drafting. Please note that some of the contents of this document may involve patents. The issuing organization of this document does not assume the responsibility for identifying patents. This document was proposed by China Light Industry Federation. This document is under the jurisdiction of the National Technical Committee on Standardization of Flavors and Fragrances and Cosmetics (SAC/TC257). This document was drafted by. Tianjin Customs Animal, Plant and Food Inspection Center. The main drafters of this document. Chen Xuyan, Ma Xing, Zhang Hua, Chang Chunyan and Li Shujing.IntroductionThe substances tested in this document are prohibited raw materials as stipulated in my country's "Technical Specifications for Safety of Cosmetics (2015 Edition)". Prohibited raw materials refer to substances that cannot be used as cosmetic raw materials. The "Cosmetic Safety Technical Specifications (2015 Edition)" stipulates. If the technical When it is unavoidable to introduce prohibited substances into cosmetics as impurities, the national limit should be followed; if no limit is set, Safety risk assessment to ensure that no harm to human health occurs under normal, reasonable and foreseeable conditions of use. At present, my country has not yet stipulated the limit values of these substances. The formulation of this document only provides detection methods for the determination of these substances in cosmetics. Amicaine, Butancaine, and Pramocaine in Cosmetics Determination of HPLC-MS/MS Warning---People who use this document should have practical experience in formal laboratory work. This document does not address all possible safety issues. The user is responsible for taking appropriate safety and health measures and ensuring that the conditions are met in accordance with relevant national regulations.1 ScopeThis document describes the determination of three caine-like substances, amicaine, butancaine and pramoxine, in cosmetics by liquid chromatography-tandem mass spectrometry. The content includes the principle of the method, reagents and materials, instruments and equipment, sample preparation and test steps, test data processing, recovery rate and precision, etc. This document applies to amicaine, butancaine, pramoxine and 3 in aqueous, liquid oil, cream, emulsion and powder cosmetics. Determination of caine-like substances. The detection limit and quantification limit of the method in this document are. the detection limit of amicaine is 1μg/kg, and the quantification limit is 3μg/kg; the detection limit of butancaine is The detection limit of pramoxine was 0.3 μg/kg, and the limit of quantification was 1 μg/kg.2 Normative referencesThe contents of the following documents constitute the essential clauses of this document through normative references in this document. For referenced documents without a date, only the version corresponding to that date applies to this document; for referenced documents without a date, the latest version (including all amendments) applies to This document. GB/T 6682 Specifications and test methods for water used in analytical laboratories3 Terms and definitionsThere are no terms or definitions that require definition in this document.4 PrincipleThe samples of water-based preparations, creams, lotions, and powders were vortexed with methanol (the samples of liquid oils were vortexed with tetrahydrofuran), and the methanol was used for determination. The target solution was injected into a liquid chromatography-tandem mass spectrometer and the target solution was centrifuged and filtered. Phase chromatography separation, mass spectrometry detection, retention time and relative ion abundance of mass spectrum for qualitative analysis, external standard method for quantitative analysis.5 Reagents and MaterialsUnless otherwise specified, only analytical grade reagents were used. 5.1 Water. GB/T 6682, Grade 1. 5.2 Methanol. chromatographic grade. 5.3 Acetonitrile. chromatographic grade. 5.4 Tetrahydrofuran. chromatographically pure. 5.5 Formic acid. chromatographic grade. 5.6 Standard substance/standard sample. purity not less than 96%. English name, CAS number, molecular weight of amicaine, butancaine, and pramoxine ......Tips & Frequently Asked Questions:Question 1: How long will the true-PDF of GB/T 45213-2025_English be delivered?Answer: Upon your order, we will start to translate GB/T 45213-2025_English as soon as possible, and keep you informed of the progress. The lead time is typically 1 ~ 3 working days. The lengthier the document the longer the lead time.Question 2: Can I share the purchased PDF of GB/T 45213-2025_English with my colleagues?Answer: Yes. The purchased PDF of GB/T 45213-2025_English will be deemed to be sold to your employer/organization who actually pays for it, including your colleagues and your employer's intranet.Question 3: Does the price include tax/VAT?Answer: Yes. Our tax invoice, downloaded/delivered in 9 seconds, includes all tax/VAT and complies with 100+ countries' tax regulations (tax exempted in 100+ countries) -- See Avoidance of Double Taxation Agreements (DTAs): List of DTAs signed between Singapore and 100+ countriesQuestion 4: Do you accept my currency other than USD?Answer: Yes. If you need your currency to be printed on the invoice, please write an email to Sales@ChineseStandard.net. In 2 working-hours, we will create a special link for you to pay in any currencies. Otherwise, follow the normal steps: Add to Cart -- Checkout -- Select your currency to pay. |