GB/T 41623-2022 English PDF

US$449.00 · In stock
Delivery: <= 4 days. True-PDF full-copy in English will be manually translated and delivered via email.
GB/T 41623-2022: Chemicals - Avian acute oral toxicity test
Status: Valid

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 41623-2022	449	Add to Cart	4 days	Chemicals - Avian acute oral toxicity test	Valid

Similar standards

GB/T 42368   GB/T 41854   GB/T 39093   GB 12268   GB/T 41622   

Basic data

Standard ID: GB/T 41623-2022 (GB/T41623-2022)
Description (Translated English): Chemicals - Avian acute oral toxicity test
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: A80
Word Count Estimation: 24,218
Issuing agency(ies): State Administration for Market Regulation, China National Standardization Administration

GB/T 41623-2022: Chemicals - Avian acute oral toxicity test

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Chemicals - Avian acute oral toxicity test ICS 13.300 CCSA80 National Standards of People's Republic of China Avian Acute Oral Toxicity Test for Chemicals Published on 2022-07-11 2023-02-01 Implementation State Administration for Market Regulation Released by the National Standardization Administration

foreword

This document is in accordance with the provisions of GB/T 1.1-2020 "Guidelines for Standardization Work Part 1.Structure and Drafting Rules of Standardization Documents" drafted. Please note that some content of this document may be patented. The issuing agency of this document assumes no responsibility for identifying patents. This document is proposed and managed by the National Standardization Technical Committee for Management of Hazardous Chemicals (SAC/TC251). This document was drafted by. Solid Waste and Chemicals Management Technology Center, Ministry of Ecology and Environment, China Academy of Inspection and Quarantine, Shanghai Testing Center, China Chemical Economic and Technological Development Center, Xiamen Yinchao Technology Co., Ltd., National Low-carbon Technology Engineering Center, Ministry of Ecology and Environment South Beijing Environmental Science Research Institute, Shenyang Chemical Research Institute Co., Ltd., Guizhou Provincial Institute of Analysis and Testing, Guangdong Quanqing Testing Co., Ltd. The main drafters of this document. Liu Chunxin, Zhou Lili, Xue Ningning, Xu Shumin, Dou Congcong, Zhang Kun, Cao Mengran, Zhao Xuming, Wang Lei, Zhao Yu, Lin Shaoxia.

Introduction

This document mainly describes three test methods used to evaluate the acute oral toxicity of chemicals to birds. limit dose test, LD50-slope rate test, LD50-single test. The LD50-slope test and the LD50-single test were performed sequentially. Depending on whether The precise oral median lethal dose (LD50) and the slope of the dose-response curve data are used to select the specific test method. Sequential test procedure The aim is to harmonize dose design, trial requirements, and precision of toxicity endpoints. Sequential testing procedures minimize the number of test birds. Curve slope and confidence interval (see 9.2). These methods were initiated by the.1994 Symposium on Avian Toxicity Testing held in Pensacola, Florida, USA, by SETAC/ OECD1) Drafted by the Working Group on Bird Toxicity Testing, and subsequently passed through SETAC open meetings in Europe and the United States and closed meetings of the OECD expert group After discussion, the sequential experimental design was revised and improved. This sequential experimental design procedure has undergone extensive statistical validation. The applicable conditions of these three test methods are as follows. ---Limited dose test. When the toxicity of the test substance is predicted to be low, and the death of the test bird is unlikely to occur under the condition of the limited dose, the test is carried out. the test. The limit dose corresponds to the purpose of evaluation and is usually set at.2000 mg/kg. Except for the control group, at the limited dose 5 or 10 test birds were tested (see Figure 1). --- LD50-slope test. when regulatory authorities or others require measurement of the slope of the dose-response curve, and/or estimated LD50 data and confidence zones time, use this method. In addition to the control group, 24 or 34 test birds were required for phase 3 or phase 4, respectively (see ---LD50-single test. when only oral median lethal dose data are required, and no dose-response curve slope or LD50 confidence interval is required , this method can be used. Can be used to estimate percentages of LD50 species sensitivity distributions and inform product labelling. the test The experiment consisted of two phases, in which 14 test birds were used in addition to the control group (see Figure 2). The LD50-slope test and the LD50-single test consist of multiple test phases performed sequentially (Figure 2). "Sequential Design" in this document "Sequential test" refers to LD50-slope test and LD50-single test. See Appendix A for the relevant design logic and statistical rationale. The parameters obtained by designing the LD50-slope test can be used for computer simulation test to achieve the purpose of hazard assessment. These parameters include LD50 values, confidence intervals and slopes of dose-response curves. At each stage of the LD50-slope test or LD50-single test design, one or more test The test birds were administered orally at one time, and the dosage unit was "mg/kg". These doses can be used to estimate LD50.The observation period after exposure was 14 days, but the main The test dose is selected according to the mortality and toxicity symptoms of the test bird three days after exposure. If the test bird dies or the symptoms recover quickly, it can be shortened. The period; if the test bird died slowly, extend the period. A sequential test (LD50-slope test or LD50-single test) is initially available from a failed limit-dose test (where one or more Try bird death) or other means to obtain information to begin. For test substances predicted to be potentially highly toxic, the test may start from Phase 1, with each There were 4 test birds in the group, and they were exposed to different doses. The dose chosen should cover the estimated LD50 range (e.g. in rodents or Based on LD50 data for other bird species). LD50 was estimated from the results of Phase 1.Stage 2 uses Maximum Likelihood Estimation (MLE) to determine A fixed dose, a total of 10 doses, each dose of 1 test bird. If the LD50 can be estimated from the failed limiting dose test, the sequential test can also be used From stage 2, the LD50-slope test can be continued to stage 3 and possibly to stage 4 (see 7.2.2.3~ 7.2.2.6). Avian Acute Oral Toxicity Test for Chemicals Caution - Persons using this document should have practical experience in formal laboratory work. This document does not address all possible security issues question. It is the user's responsibility to take appropriate safety and health measures and to ensure compliance with the conditions stipulated by relevant national regulations.

1 Scope

This document specifies the test substance information, test principle, test method, test procedure, quality assurance and quality assurance of bird acute oral toxicity test. Volume control, data and reporting. This document applies to the evaluation of acute oral exposure to birds of chemicals of low volatility and of adequate accuracy and sensitivity. toxicity. This document does not apply to acute oral toxicity testing of highly volatile chemicals.

2 Normative references

The contents of the following documents constitute essential provisions of this document through normative references in the text. Among them, dated citations documents, only the version corresponding to that date applies to this document; for undated references, the latest edition (including all amendments) applies to this document. GB/T 21801 Chemical Rapid Biodegradability Respirometry Test GB/T 21802 Chemical Rapid Biodegradability Improvement MITI Test (I) GB/T 21803 Chemical Rapid Biodegradability DOC Reduction Test GB/T 21810 Chemical Bird Diet Toxicity Test GB/T 21811 Chemical Bird Breeding Test GB/T 21831 Chemical rapid biodegradability closed bottle method test GB/T 21845 Chemical Water Solubility Test GB/T 21852 Chemical Partition Coefficient (n-Octanol-Water) High Performance Liquid Chromatography Test GB/T 21853 Chemical Partition Coefficient (n-Octanol-Water) Shake Flask Test GB/T 21855 Hydrolysis test of chemicals related to pH GB/T 21856 Chemical Rapid Biodegradable Carbon Dioxide Generation Test GB/T 21857 OECD Screening Test for Improved Rapid Biodegradability of Chemicals GB/T 22052 Method for Determining Liquid Vapor Pressure Temperature Relationship and Initial Decomposition Temperature with Liquid Vapor Manometer GB/T 22228 Static method for the determination of the vapor pressure of solids and liquids in industrial chemicals in the range of 10-1Pa to 105Pa GB/T 22229 Determination of the vapor pressure of solids and liquids of industrial chemicals in the range of 10-3Pa to 1Pa Vapor pressure level balance method GB/T 27850 General rules for rapid biodegradability of chemicals OECD Chemical Testing Guideline No.104 Vapor Pressure (VapourPressure)

3 Terms and Definitions

The following terms and definitions apply to this document. ......

Image     

Tips & Frequently Asked Questions:

Question 1: How long will the true-PDF of GB/T 41623-2022_English be delivered?

Answer: Upon your order, we will start to translate GB/T 41623-2022_English as soon as possible, and keep you informed of the progress. The lead time is typically 2 ~ 4 working days. The lengthier the document the longer the lead time.

Question 2: Can I share the purchased PDF of GB/T 41623-2022_English with my colleagues?

Answer: Yes. The purchased PDF of GB/T 41623-2022_English will be deemed to be sold to your employer/organization who actually pays for it, including your colleagues and your employer's intranet.

Question 3: Does the price include tax/VAT?

Answer: Yes. Our tax invoice, downloaded/delivered in 9 seconds, includes all tax/VAT and complies with 100+ countries' tax regulations (tax exempted in 100+ countries) -- See Avoidance of Double Taxation Agreements (DTAs): List of DTAs signed between Singapore and 100+ countries

Question 4: Do you accept my currency other than USD?

Answer: Yes. If you need your currency to be printed on the invoice, please write an email to Sales@ChineseStandard.net. In 2 working-hours, we will create a special link for you to pay in any currencies. Otherwise, follow the normal steps: Add to Cart -- Checkout -- Select your currency to pay.