GB/T 37644-2019 English PDF

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GB/T 37644-2019: Determination of oxyquinoline and nitroxoline in cosmetics - High performance liquid chromatography
Status: Valid

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 37644-2019	199	Add to Cart	3 days	Determination of oxyquinoline and nitroxoline in cosmetics - High performance liquid chromatography	Valid

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Basic data

Standard ID: GB/T 37644-2019 (GB/T37644-2019)
Description (Translated English): Determination of oxyquinoline and nitroxoline in cosmetics - High performance liquid chromatography
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: Y42
Classification of International Standard: 71.100.70
Word Count Estimation: 10,178
Date of Issue: 2019-06-04
Date of Implementation: 2020-01-01
Issuing agency(ies): State Administration for Market Regulation, China National Standardization Administration

GB/T 37644-2019: Determination of oxyquinoline and nitroxoline in cosmetics - High performance liquid chromatography

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Determination of oxyquinoline and nitroxoline in cosmetics--High performance liquid chromatography ICS 71.100.70 Y42 National Standards of People's Republic of China Determination of 8-hydroxyquinoline and nitroquinoline in cosmetics High performance liquid chromatography Published on.2019-06-04 2020-01-01 implementation State market supervision and administration China National Standardization Administration issued

Foreword

This standard was drafted in accordance with the rules given in GB/T 1.1-2009. This standard was proposed by the China Light Industry Association. This standard is under the jurisdiction of the National Spice and Fragrance Cosmetics Standardization Technical Committee (SAC/TC257). This standard was drafted. Suzhou Shipu Testing Technology Co., Ltd., Yangzhou Perfect Daily Necessities Co., Ltd., Jiangsu Longliqi Biotechnology Co., Ltd. Co., Ltd., Shanghai Daily Chemical Industry Research Institute, Guangzhou Huaxin Testing Technology Co., Ltd., Guangzhou Quality Supervision and Testing Institute, Shanghai China Pharmaceutical Nantong Co., Ltd., Oushi Man Bio Co., Ltd., Suzhou Food and Drug Administration, Suzhou Drug Testing Research Center, Zhejiang Fangyuan Testing Group Co., Ltd., Suzhou Quality Inspection Science Research Institute, Hebei Food Inspection Institute, Jiangsu Province Product Quality Supervision and Inspection Institute, Jiangsu Food and Drug Administration and Inspection Institute, Infinitus (China) Co., Ltd. The main drafters of this standard. Zhang Zheng, Liu Donghong, Tong Yan, Dai Dan, Huang Hongxia, Zhou Jianqing, Wang Li, Qi Yeguo, Liao Huayong, Chen Wei, Shen Min, Zhao Yongguo, Zhang Lihua, Lu Xiaoyu, Jin Jiayu, Yang Wei, Zhang Fang, Zhang Yan, Kang Wei, Fan Sufang, Ye Zhuhong, Yan Xin, Liang Ming, Wang Bin, Jin Feng, Huang Yufeng, Xun Zhiqing, Yan Yanping, Shi Bing, Liu Qunlin, Zhi Zijin, Zhu Yan, Hou Xiangyu, Wu Yuxi, Guo Xindong, Lu Jian, Sun Hongmei.

Introduction

The test substance of this standard, nitroquinoline, is a banned substance stipulated in China's Cosmetic Safety Technical Specification (2015 Edition). A banned substance is a substance that cannot be added to a cosmetic as a raw material for cosmetic production. Cosmetics Safety Technical Specifications (2015 edition) stipulates. If it is technically impossible to avoid the banned substances as impurities into the cosmetics, a safety risk assessment should be carried out to ensure Under normal, reasonable and foreseeable conditions of use, no harm may be caused to human health. At present, China has not specified the limit value of these substances. This standard only provides testing methods for the determination of these substances in cosmetics. Determination of 8-hydroxyquinoline and nitroquinoline in cosmetics High performance liquid chromatography

1 Scope

This standard specifies the principles, reagents and materials for the HPLC method for the determination of 8-hydroxyquinoline and nitroquinoline in cosmetics. Equipment, test procedures, calculation of results, recovery and precision, allowable difference, etc. This standard applies to the determination of 8-hydroxyquinoline and nitroquinoline in cosmetics. The detection limit and limit of quantification of this standard. cosmetics (except wax base, powder). the detection limit of 8-hydroxyquinoline and nitroquinoline is 1.5mg/kg, the limit of quantification is 5.0mg/kg; the detection limit of wax-based and powder cosmetics. 8-hydroxyquinoline and nitroquinoline is 3.0mg/kg, quantitative The limit is 10.0 mg/kg.

2 Normative references

The following documents are indispensable for the application of this document. For dated references, only dated versions apply to this article. Pieces. For undated references, the latest edition (including all amendments) applies to this document. GB/T 6682 Analytical laboratory water specifications and test methods

3 Principle

The 8-hydroxyquinoline and nitroquinoline in the sample were ultrasonically extracted by solvent, and the high performance liquid chromatograph equipped with a diode array detector was used. Determination, retention time and spectrogram qualitative, external standard method for quantification. High performance liquid chromatography-mass spectrometry/mass spectrometry legal confirmation.

4 reagents and materials

4.1 Water. Primary water specified in GB/T 6682. 4.2 Methanol. Chromatographically pure. 4.3 Acetonitrile. Chromatographically pure. 4.4 Formic acid. chromatographically pure. 4.5 Phosphoric acid. analytically pure. 4.6 Sodium octane sulfonate. analytically pure. 4.7 Reference material. The purity is not less than 98%. Chinese name and INCI name of 8-hydroxyquinoline and nitroquinoline (International cosmetic raw material name) See)/English name, CAS number, molecular formula, relative molecular mass and structural formula, see Table A.1 in Appendix A. 4.8 0.01mol/L sodium octane sulfonate solution. Weigh 1.08g sodium octane sulfonate (4.6), dilute with water to 500mL, and adjust with phosphoric acid (4.5) The pH is adjusted to 2.5. 4.9 Aqueous Phosphoric Acid Solution. Pipette an appropriate amount of water and adjust the pH to 2.5 with phosphoric acid (4.5). 4.10 Methanol - 0.01 mol/L sodium octane sulfonate solution. methanol 0.01 mol/L sodium octane sulfonate solution = 7 3 (volume ratio). 4.11 Formic acid-acetonitrile solution. acetonitrile formic acid = 1 99 (volume ratio). 4.12 Aqueous solution of methanol-phosphoric acid. aqueous solution of methanolic phosphoric acid = 7 3 (volume ratio). 4.13 Mixed standard working solution. Accurately weigh the standard substance (4.7) 10.0mg (accurate to 0.1mg) with methanol-0.01mol/L octane Dissolve sodium sulfonate solution (4.10) and dilute to 10mL to obtain standard stock solution (ρ=1000.0mg/L, preserved at 4°C from light, can be protected Save for 2 months). Transfer the appropriate amount of standard stock solution separately and dilute to mass with methanol-0.01mol/L sodium octane sulfonate solution (4.10). ......

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