GB/T 15670.4-2017 English PDF

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GB/T 15670.4-2017: Toxicological test methods for pesticides registration -- Part 4: Acute oral toxicity test -- Miller and Tainter method
Status: Valid

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 15670.4-2017	179	Add to Cart	3 days	Toxicological test methods for pesticides registration -- Part 4: Acute oral toxicity test -- Miller and Tainter method	Valid

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Basic data

Standard ID: GB/T 15670.4-2017 (GB/T15670.4-2017)
Description (Translated English): Toxicological test methods for pesticides registration -- Part 4: Acute oral toxicity test -- Miller and Tainter method
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: B17
Classification of International Standard: 65.100
Word Count Estimation: 9,918
Date of Issue: 2017-07-12
Date of Implementation: 2018-02-01
Older Standard (superseded by this standard): GB/T 15670-1995 Partly
Quoted Standard: GB 14925
Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China
Summary: This standard specifies the basic principles, methods and requirements for the probabilistic unit method of acute oral toxicity test. This standard applies to acute oral toxicity tests for pesticide registration.

GB/T 15670.4-2017: Toxicological test methods for pesticides registration -- Part 4: Acute oral toxicity test -- Miller and Tainter method

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Toxicological test methods for pesticides registration. Part 4. Acute oral toxicity test. Miller and Taninter "" s method ICS 65.100 B17 National Standards of People's Republic of China Partially replace GB/T 15670-1995 Pesticide registration Toxicology test methods Part 4. Acute oral toxicity test Probability unit method Part 4.Acuteoraltoxicitytest-MilerandTaninter'smethod 2017-07-12 Posted 2018-02-01 implementation General Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China China National Standardization Administration released

Foreword

GB/T 15670 "pesticide registration toxicology test method" is divided into the following sections. --- Part 1. General principles; --- Part 2. Acute oral toxicity test Horn's method; --- Part 3. Acute oral toxicity test sequential method; --- Part 4. Acute oral toxicity test probability unit method; --- Part 5. Acute dermal toxicity test; --- Part 6. Acute inhalation toxicity test; --- Part 7. Skin irritation/corrosivity test; --- Part 8. Acute eye irritation/corrosiveness test; --- Part 9. Skin allergy (sensitization) test; --- Part 10. Short-term repeated oral toxicity (28 days) toxicity test; --- Part 11. Short-term repeated transdermal (28 days) toxicity test; --- Part 12. Short-term repeated inhalation exposure (28 days) toxicity test; --- Part 13. Subchronic toxicity test; --- Part 14. bacterial recovery mutation test; --- Part 15. In vivo mammalian bone marrow polychromatic erythrocyte micronucleus test; --- Part 16. In vivo mammalian bone marrow cell chromosome aberration test; --- Part 17. Mammalian spermatogonial/spermatocyte chromosome aberration test; --- Part 18. Rodent dominant lethality test; --- Part 19. In vitro mammalian chromosome aberration test; --- Part 20. In vitro mammalian cell gene mutation test; --- Part 21. In vivo mammalian hepatocyte extracellular DNA synthesis (UDS) test; --- Part 22. DNA damage and repair in vitro mammalian cells/DNA synthesis test outside the program; --- Part 23. Teratogenicity test; --- Part 24. Two generations of reproductive toxicity test; --- Part 25. Acute delayed neurotoxicity test; --- Part 26. Chronic toxicity test; --- Part 27. Carcinogenicity test; --- Part 28. Chronic toxicity and carcinogenicity combined test; --- Part 29. Metabolism and toxicokinetic tests. This section GB/T 15670 Part 4. This section drafted in accordance with GB/T 1.1-2009 given rules. Part of this section instead of GB/T 15670-1995 "pesticide registration toxicology test methods." This section and GB/T 15670-1995 Acute oral toxicity test section compared to the main changes. --- Modify and adjust the overall structure and layout format; --- Added some clauses (see Chapter 1, Chapter 2, Chapter 3, Chapter 5, 6.4, Chapter 8); --- Added Appendix A "response rate - probability table" and Appendix B "response rate 0% and 100% of the approximate value of the unit of probability." This part is proposed and managed by the Ministry of Agriculture of the People's Republic of China. This part of the drafting unit. Ministry of Agriculture pesticide test. The main drafters of this section. He Xiwen, Zhang Liying, Qu 甍 甍, Tao Chuanjiang. This part replaces the standards previously issued as. --- GB/T 15670-1995. Pesticide registration Toxicology test methods Part 4. Acute oral toxicity test Probability unit method

1 Scope

This section GB/T 15670 specifies the basic principles, methods and requirements of the acute oral toxicity test probability unit method. This section applies to pesticides registered acute oral toxicity test.

2 Normative references

The following documents for the application of this document is essential. For dated references, only the dated version applies to this article Pieces. For undated references, the latest edition (including all amendments) applies to this document. GB 14925 laboratory animal environment and facilities Pesticide registration information requirements (People's Republic of China Ministry of Agriculture Order 〔2007〕 No. 10)

3 Terms and definitions

The following terms and definitions apply to this document. 3.1 Acute oral toxicity of acuteoraltoxicity The effects of health damage to animals in the short term after one or more oral administration of the test animal substance within 24 hours. 3.2 Dose dose The amount of test substance given is expressed as mass of test article received per unit body weight of test animal (mg/kg body weight). 3.3 Median lethal dose medianlethaldose LD50 Once or within 24 hours of repeated administration of test animal compounds, the overall experimental animals caused half of the total dose of toxicants statistics. The test animal's body weight to accept the test substance mass (mg/kg body weight). 3.4 Dose-response relationship dose-responserelationship Relationship between dose and incidence of specific effects.

4 test purposes

Acute oral toxicity test is the first step to evaluate the toxicity of pesticides. The toxicity characteristics of the test substance are first understood through short-term oral exposure. Dose-response relationship for the acute toxicity grading, label management and other toxicology test dose basis. ......

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