GB/T 15670.23-2017 English PDF

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GB/T 15670.23-2017: Toxicological test methods for pesticides registration -- Part 23: Teratogenicity study
Status: Valid

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 15670.23-2017	159	Add to Cart	3 days	Toxicological test methods for pesticides registration -- Part 23: Teratogenicity study	Valid

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GB/T 15670.3   GB/T 15670.16   GB/T 15670.21   GB/T 15670.17   GB/T 15670.18   GB/T 15670.15   

Basic data

Standard ID: GB/T 15670.23-2017 (GB/T15670.23-2017)
Description (Translated English): Toxicological test methods for pesticides registration -- Part 23: Teratogenicity study
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: B17
Classification of International Standard: 65.100
Word Count Estimation: 8,826
Date of Issue: 2017-07-12
Date of Implementation: 2018-02-01
Older Standard (superseded by this standard): GB/T 15670-1995 Partly
Quoted Standard: GB 14925
Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China
Summary: This standard specifies the basic principles, methods and requirements for teratogenic testing. This standard applies to teratogenic tests for pesticide registration.

GB/T 15670.23-2017: Toxicological test methods for pesticides registration -- Part 23: Teratogenicity study

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Toxicological test methods for pesticides registration. Part 23. Teratogenicity study ICS 65.100 B17 National Standards of People's Republic of China Partially replace GB/T 15670-1995 Pesticide registration Toxicology test methods Part 23. Teratogenicity test Part 23 .Teratogenicitystudy 2017-07-12 Posted 2018-02-01 implementation General Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China China National Standardization Administration released

Foreword

GB/T 15670 "pesticide registration toxicology test method" is divided into the following sections. --- Part 1. General principles; --- Part 2. Acute oral toxicity test Horn's method; --- Part 3. Acute oral toxicity test sequential method; --- Part 4. Acute oral toxicity test probability unit method; --- Part 5. Acute dermal toxicity test; --- Part 6. Acute inhalation toxicity test; --- Part 7. Skin irritation/corrosivity test; --- Part 8. Acute eye irritation/corrosiveness test; --- Part 9. Skin allergy (sensitization) test; --- Part 10. Short-term repeated oral toxicity (28 days) toxicity test; --- Part 11. Short-term repeated transdermal (28 days) toxicity test; --- Part 12. Short-term repeated inhalation exposure (28 days) toxicity test; --- Part 13. Subchronic toxicity test; --- Part 14. bacterial recovery mutation test; --- Part 15. In vivo mammalian bone marrow polychromatic erythrocyte micronucleus test; --- Part 16. In vivo mammalian bone marrow cell chromosome aberration test; --- Part 17. Mammalian spermatogonial/spermatocyte chromosome aberration test; --- Part 18. Rodent dominant lethality test; --- Part 19. In vitro mammalian chromosome aberration test; --- Part 20. In vitro mammalian cell gene mutation test; --- Part 21. In vivo mammalian hepatocyte extracellular DNA synthesis (UDS) test; --- Part 22. DNA damage and repair in vitro mammalian cells/DNA synthesis test outside the program; --- Part 23. Teratogenicity test; --- Part 24. Two generations of reproductive toxicity test; --- Part 25. Acute delayed neurotoxicity test; --- Part 26. Chronic toxicity test; --- Part 27. Carcinogenicity test; --- Part 28. Chronic toxicity and carcinogenicity combined test; --- Part 29. Metabolism and toxicokinetic tests. This section GB/T 15670 Part 23. This section drafted in accordance with GB/T 1.1-2009 given rules. Part of this section instead of GB/T 15670-1995 "pesticide registration toxicology test methods." This section and GB/T 15670-1995 teratogenic test section compared to the main changes are as follows. --- Modify and adjust the standard of the overall structure and layout format; --- Added some sections (see Chapter 1, Chapter 2, Chapter 3, Chapter 5, Chapter 6, 7.1 and Chapter 9); --- Modify the requirements of experimental animals (see 7.2,.1995 edition of 15.3); --- Modified dose and grouping (see 7.3,.1995 version 15.5); --- In the body surface, visceral and skeletal items, the examination item list is deleted (see 7.4.4.2, 7.4.4.3 and 7.4.4.4.1995 Version 15.9.3 and 15.9.4); --- Visceral and skeletal observation, an increase of the observation program, bone staining methods and rabbit visceral observation and bone observation content (see 7.4.4.3 and 7.4.4.4.4,.1995 edition 15.9.4). This part is proposed and managed by the Ministry of Agriculture of the People's Republic of China. This part of the drafting unit. Ministry of Agriculture pesticide test. The main drafters of this section. Li Ning, Zhang Liying, Tao Chuanjiang. This part replaces the standards previously issued as. --- GB/T 15670-1995. Pesticide registration Toxicology test methods Part 23. Teratogenicity test

1 Scope

GB/T 15670 provisions of this part of the teratogenicity test the basic principles, methods and requirements. This section applies to pesticide registration teratogenicity test.

2 Normative references

The following documents for the application of this document is essential. For dated references, only the dated version applies to this article Pieces. For undated references, the latest edition (including all amendments) applies to this document. GB 14925 laboratory animal environment and facilities

3 Terms and definitions

The following terms and definitions apply to this document. 3.1 Teratogenicity The characteristics of chemicals that cause permanent structural and functional abnormalities in offspring during embryonic development. 3.2 Maternal toxicity Cause direct or indirect effects of health damage on the parent female pregnancy animal.

4 test purposes

Detection of gestational animal exposure to test substance caused by the generation of teratogenic potential.

5 Test Overview

Sexually matured female animals are mated with male animals, pregnant women are randomly assigned to each dose group, Pregnancy animal embryonic developmental organism given to the test substance exposure, and the offspring are expected to be born before the birth of the mother, remove the uterus, check the absorption Fetal, live, stillbirth and fetal appearance, visceral and skeletal deformities.

6 instruments and reagents

6.1 Instrument Laboratory equipment, biological microscopes and stereomicroscopes, vernier caliper (scale) and so on. ......

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