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GB/T 40895-2021 English PDF

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GB/T 40895-2021: Determination of prohibited tetracaine and its salts in cosmetics - Ion chromatography
Status: Valid
Standard IDUSDBUY PDFLead-DaysStandard Title (Description)Status
GB/T 40895-2021189 Add to Cart 3 days Determination of prohibited tetracaine and its salts in cosmetics - Ion chromatography Valid

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Basic data

Standard ID: GB/T 40895-2021 (GB/T40895-2021)
Description (Translated English): Determination of prohibited tetracaine and its salts in cosmetics - Ion chromatography
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: Y42
Word Count Estimation: 10,121
Issuing agency(ies): State Administration for Market Regulation, China National Standardization Administration

GB/T 40895-2021: Determination of prohibited tetracaine and its salts in cosmetics - Ion chromatography


---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Determination of prohibited tetracaine and its salts in cosmetics - Ion chromatography ICS 71.100.70 CCSY42 National Standards of People's Republic of China Determination of Prohibited Substance Tetracaine and Its Salts in Cosmetics Ion chromatography Released on 2021-11-26 2022-06-01 implementation State Administration for Market Regulation Issued by the National Standardization Management Committee

Foreword

This document is in accordance with the provisions of GB/T 1.1-2020 "Guidelines for Standardization Work Part 1.Structure and Drafting Rules of Standardization Documents" Drafting. Please note that some of the contents of this document may involve patents. The issuing agency of this document is not responsible for identifying patents. This document was proposed by the China National Light Industry Council. This document is under the jurisdiction of the National Standardization Technical Committee for Fragrance, Flavor and Cosmetics (SAC/TC257). Drafting organizations of this document. China Academy of Inspection and Quarantine Sciences, Shanghai Perfume Research Institute. The main drafters of this document. Guo Xiangyu, Ma Qiang, Yang Haifeng, Li Wentao, Chen Meng, Meng Xianshuang.

Introduction

The tested substances in this document are prohibited raw materials stipulated in my country's "Cosmetics Safety Technical Specifications (2015 Edition)". Prohibited raw materials refer to substances that cannot be used as cosmetic raw materials. The "Cosmetics Safety Technical Specification (2015 Edition)" stipulates that if the technology When banned substances are brought into cosmetics as impurities in the above-mentioned inevitability, the state's limited amount shall comply with its regulations; if the limit is not specified, it shall be carried out. Safety risk assessment ensures that no harm to human health will occur under normal, reasonable and foreseeable use conditions. At present, my country has not stipulated the limit value of these substances. The formulation of this document only provides detection methods for the determination of these substances in cosmetics. Determination of Prohibited Substance Tetracaine and Its Salts in Cosmetics Ion chromatography Warning---Personnel using this document should have practical experience in formal laboratory work. This document does not indicate all possible safety issues question. The user is responsible for taking appropriate safety and health measures and ensuring compliance with the relevant state regulations.

1 Scope

This document describes the principles, reagents and materials, and instrument design of the ion chromatography method for the determination of tetracaine and its salts, which are prohibited substances in cosmetics. Preparation, test procedures, test data processing, recovery rate, precision, etc. This document is applicable to the determination of tetracaine and its salts in emulsions, liquids, facial cleansers and facial mask cosmetics. In this document, the detection limit of tetracaine and its salts (in tetracaine) is 10mg/kg, and the limit of quantification is 25mg/kg.

2 Normative references

The content of the following documents constitutes an indispensable clause of this document through normative references in the text. Among them, dated quotations Only the version corresponding to the date is applicable to this document; for undated reference documents, the latest version (including all amendments) is applicable to This document. GB/T 6682 Analytical laboratory water specifications and test methods

3 Terms and definitions

There are no terms and definitions that need to be defined in this document.

4 Principle

After the sample is extracted by solvent ultrasonic, filtered by microporous membrane and purified by solid phase extraction column, the sample liquid is separated by ion chromatography, using a conductivity detector Carry out the determination, preliminary qualitative according to the retention time, quantification by external standard method.

5 Reagents and materials

Unless otherwise specified, only use analytical reagents. 5.1 Water, GB/T 6682, level one. 5.2 Methanol. chromatographically pure. 5.3 Concentrated nitric acid. the concentration is 16mol/L. 5.4 Hydrochloric acid. 36% mass fraction. 5.5 Sodium chloride. solid. 5.6 Tetracaine standard substance. molecular formula C15H24N2O2, CAS number 94-24-6, purity not less than 99%, structural formula see Appendix A Figure A.1. 5.7 4mmol/L nitric acid solution. Take 0.25mL concentrated nitric acid (5.3) and add it to a 1000mL volumetric flask, dilute with water and dilute to the mark.
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