GB/T 40894-2021 English PDF

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GB/T 40894-2021: Determination of prohibited substances thiamazole in cosmetics - High performance liquid chromatography
Status: Valid

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GB/T 42425   GB/T 40146   GB/T 37625   GB/T 40895   GB/T 40891   

Basic data

Standard ID: GB/T 40894-2021 (GB/T40894-2021)
Description (Translated English): Determination of prohibited substances thiamazole in cosmetics - High performance liquid chromatography
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: Y42
Word Count Estimation: 10,173
Issuing agency(ies): State Administration for Market Regulation, China National Standardization Administration

GB/T 40894-2021: Determination of prohibited substances thiamazole in cosmetics - High performance liquid chromatography

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Determination of prohibited substances thiamazole in cosmetics - High performance liquid chromatography ICS 71.100.70 CCSY42 National Standards of People's Republic of China Determination of methimazole, a banned substance in cosmetics High performance liquid chromatography Released on 2021-11-26 2022-06-01 implementation State Administration for Market Regulation Issued by the National Standardization Management Committee

Foreword

This document is in accordance with the provisions of GB/T 1.1-2020 "Guidelines for Standardization Work Part 1.Structure and Drafting Rules of Standardization Documents" Drafting. Please note that some of the contents of this document may involve patents. The issuing agency of this document is not responsible for identifying patents. This document was proposed by the Federation of Light Industry. This document is under the jurisdiction of the National Standardization Technical Committee for Fragrance, Flavor and Cosmetics (SAC/TC257). Drafting organizations of this document. Shanghai Institute of Perfume, Shanghai Institute of Quality Supervision and Inspection Technology, Infinitus (China) Co., Ltd., Guangzhou Keneng Cosmetics Scientific Research Co., Ltd. The main drafters of this document. Nie Lei, Yang Bin, Sun Hongmei, Li Chuanmao, Yan Qing, Yu Suoyin, Gu Yuxiang, Li Meizhen.

Introduction

The tested substances in this document are prohibited raw materials stipulated in my country's "Cosmetics Safety Technical Specifications (2015 Edition)". Prohibited raw materials refer to substances that cannot be used as cosmetic raw materials. The "Cosmetics Safety Technical Specification (2015 Edition)" stipulates that if the technology When banned substances are brought into cosmetics as impurities in the above-mentioned inevitability, the state's limited amount shall comply with its regulations; if the limit is not specified, it shall be carried out. Safety risk assessment ensures that no harm to human health will occur under normal, reasonable and foreseeable use conditions. At present, my country has not stipulated the limit value of this substance. The formulation of this document only provides detection methods for the determination of this substance in cosmetics. Determination of methimazole, a banned substance in cosmetics High performance liquid chromatography

1 Scope

This document describes the principles, reagents and materials, equipment, and test procedures of the high performance liquid chromatography method for the determination of methimazole in cosmetics. Steps, test data processing, recovery rate, precision, etc. This document is applicable to the determination of methimazole in liquids, creams, and emulsion cosmetics. The detection limit of the method in this document is 0.33mg/kg, and the limit of quantification is 1.0mg/kg.

2 Normative references

The content of the following documents constitutes an indispensable clause of this document through normative references in the text. Among them, dated quotations Only the version corresponding to the date is applicable to this document; for undated reference documents, the latest version (including all amendments) is applicable to This document. GB/T 6682 Analytical laboratory water specifications and test methods

3 Terms and definitions

There are no terms and definitions that need to be defined in this document.

4 Principle

The sample is vortexed with methanol, ultrasonically extracted, centrifuged, separated and filtered, separated by reversed-phase high performance liquid chromatography, and detected by a diode array. Detector detection, qualitative according to retention time and diode array (DAD) spectrogram, quantitative with external standard method.

5 Reagents and materials

Unless otherwise specified, only use chromatographically pure reagents. 5.1 Water, GB/T 6682, level one. 5.2 Methanol. 5.3 50% (volume fraction) methanol aqueous solution. Take 50mL methanol and 50mL water, mix well. 5.4 Methimazole standard product. The purity is greater than 99%, the English name of methimazole, the international cosmetic raw material name (INCI), CAS number, and The sub-formula, relative molecular mass and structural formula are shown in Table A.1 in Appendix A. 5.5 Methimazole standard stock solution. accurately weigh 10 mg of the standard product to the nearest 0.1 mg, and place it in a 10 mL volumetric flask with methanol (5.2) Dissolve and dilute to the mark to obtain a standard stock solution with a mass concentration of methimazole of 1000 μg/mL. Store in the refrigerator at -18℃, available The validity period is 6 months.

6 Equipment

6.1 High performance liquid chromatograph. equipped with diode array detector. ......

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