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GB/T 40845-2021 English PDF

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GB/T 40845-2021: Determination of azelaic acid in cosmetics - Gas chromatography method
Status: Valid
Standard IDUSDBUY PDFLead-DaysStandard Title (Description)Status
GB/T 40845-2021159 Add to Cart 3 days Determination of azelaic acid in cosmetics - Gas chromatography method Valid

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Basic data

Standard ID: GB/T 40845-2021 (GB/T40845-2021)
Description (Translated English): Determination of azelaic acid in cosmetics - Gas chromatography method
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: Y42
Word Count Estimation: 8,868
Issuing agency(ies): State Administration for Market Regulation, China National Standardization Administration

GB/T 40845-2021: Determination of azelaic acid in cosmetics - Gas chromatography method

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Determination of azelaic acid in cosmetics - Gas chromatography method ICS 71.100.70 CCSY42 National Standards of People's Republic of China Determination of Azelaic Acid in Cosmetics by Gas Chromatography Released on 2021-10-11 2022-05-01 implementation State Administration for Market Regulation Issued by the National Standardization Management Committee

Foreword

This document is in accordance with the provisions of GB/T 1.1-2020 "Guidelines for Standardization Work Part 1.Structure and Drafting Rules of Standardization Documents" Drafting. Please note that some of the contents of this document may involve patents. The issuing agency of this document is not responsible for identifying patents. This document was proposed and managed by the National Standardization Technical Committee on Inspection Methods for Key Products of Quality Supervision (SAC/TC374). Drafting organizations of this document. Shanghai Institute of Quality Supervision and Inspection Technology, CCIC Warner (Beijing) Quality Technology Center Co., Ltd., Shanghai Municipal Medical Device Cosmetics Review and Inspection Center, Yujiahui Co., Ltd., Guangdong Marumi Biotechnology Co., Ltd., Warner Pass (Beijing) Certification Co., Ltd., China Inspection Alliance (Beijing) Quality Inspection Technology Research Institute Co., Ltd. The main drafters of this document. Zhou Yaobin, Zhao Yanju, Ning Xiaojun, Lan Xu, Lu Zhiyun, Yu Chenghua, Yi Jing, Zhou Jing, Liu Shu, Gu Yuxiang, Meng Jie, Dai Yuefeng, Sun Yunqi, Zou Yaxiong, Zheng Cunzhe, Chen Dongyang. Determination of Azelaic Acid in Cosmetics by Gas Chromatography

1 Scope

This document specifies the principle, reagents and materials, equipment, test procedures, and calculation of results for the determination of azelaic acid in cosmetics by gas chromatography And precision. This document is applicable to the determination of azelaic acid in lotions, creams, lotions and facial mask cosmetics.

2 Normative references

The content of the following documents constitutes an indispensable clause of this document through normative references in the text. Among them, dated quotations Only the version corresponding to the date is applicable to this document; for undated reference documents, the latest version (including all amendments) is applicable to This document. GB/T 6682 Analytical laboratory water specifications and test methods

3 Terms and definitions

There are no terms and definitions that need to be defined in this document.

4 Principle

The sample is derived under the conditions of concentrated sulfuric acid and ethanol, extracted with n-hexane, concentrated, separated by gas chromatography, and detected by a hydrogen flame ionization detector. Measured, qualitatively based on retention time, and quantified by external standard method.

5 Reagents and materials

Unless otherwise specified, only use analytical reagents. 5.1 Water, GB/T 6682, Class II. 5.2 Methanol-free ethanol, chromatographically pure, take 1.0μL into the gas chromatograph, there should be no impurity peaks, no methanol detected. 5.3 n-hexane, chromatographically pure. 5.4 Concentrated sulfuric acid. 5.5 Sodium bicarbonate. 5.6 Saturated sodium bicarbonate solution. Take a sufficient amount of sodium bicarbonate (5.5) in a 500mL beaker, dissolve it with water until sodium bicarbonate precipitates, and store it. In a 500mL reagent bottle, keep sodium bicarbonate powder at the bottom of the bottle. 5.7 Standard azelaic acid. purity not less than 98.0%, CAS number. 123-99-9, molecular formula C9H16O4, relative molecular mass 188.22. 5.8 Standard stock solution of azelaic acid, 10.0mg/mL. accurately weigh 1g of standard azelaic acid (5.7), accurate to 0.0001g, in 100mL In the volumetric flask, dissolve (5.2) with methanol-free ethanol and dilute the volume to obtain a standard stock solution of azelaic acid with a mass concentration of 10.0 mg/mL. Store at -18℃, the shelf life is 6 months. 5.9 Standard working curve solution. Use methanol-free ethanol (5.2) to prepare the above standard stock solution (5.8) into a series of mass concentrations. Standard working solutions of 50mg/L, 100mg/L, 250mg/L, 500mg/L, 1000mg/L, 2500mg/L, 5000mg/L,
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