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GB/T 28236-2011 English PDF

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GB/T 28236-2011: Method of chromosome aberration analysis for biological dose assessment
Status: Valid
Standard IDUSDBUY PDFLead-DaysStandard Title (Description)Status
GB/T 28236-2011399 Add to Cart 3 days Method of chromosome aberration analysis for biological dose assessment Valid

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Basic data

Standard ID: GB/T 28236-2011 (GB/T28236-2011)
Description (Translated English): Method of chromosome aberration analysis for biological dose assessment
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: C60
Classification of International Standard: 13.100
Word Count Estimation: 17,128
Date of Issue: 2011-12-30
Date of Implementation: 2012-05-01
Older Standard (superseded by this standard): GB/T 12715-1991
Regulation (derived from): Announcement of Newly Approved National Standards No. 23 of 2011
Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China
Summary: This standard specifies the ionizing radiation-induced chromosomal aberrations in human peripheral blood lymphocytes in a dose response curve for the establishment and use it to estimate the biological dose approach. This standard applies to a relatively uniform body external radiation accident exposed personnel dose estimation. This standard also applies to a relatively uniform body external radiation dose estimation and burn cases. This standard does not apply to fractionated irradiation, the cumulative long-term low-dose radiation and internal irradiation of biological dose estimates.

GB/T 28236-2011: Method of chromosome aberration analysis for biological dose assessment

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Method of chromosome aberration analysis for biological dose assessment ICS 13.100 C60 National Standards of People's Republic of China Chromosome aberrations biological dose estimation method Issued on. 2011-12-30 2012-05-01 implementation People's Republic of China Ministry of Health Standardization Administration of China released

Foreword

This standard replaces GB/T 12715-1991 "chromosome aberration analysis method of estimating biological dose." This standard compared with GB/T 12715-1991 main changes are as follows. --- Complement the scope of the standard "applies to a relatively uniform biological dose whole body irradiation and burn the outer case estimate"; --- Will be a more accurate estimate of the time change amount of blood 60d. --- Culture began to increase its emphasis on law and colchicine dose estimates with dic (or "dic r"); --- Increasing the statistical test and the biological dose estimation methods and local non-uniform irradiation; --- Original basic standards is quoted IAEA Technical Report Series No. 260 (1986), to maximize the use of this standard information, such as dyeing Figure aberrations, biological dose estimates, for example, some of the statistical analysis method, the effective time and estimated blood dose precautions. It also cited references and IAEA Technical Report Series No. 405 (2001) of the content. This standard is a normative appendix Appendix A and Appendix B is an informative annex. This standard is proposed and administered by the People's Republic of China Ministry of Health. This standard was drafted. Chinese Center for Disease Control Radiation Protection and Nuclear Safety of the medicine. The main drafters of this standard. white book. This standard by the People's Republic of China Ministry of Health is responsible for interpretation. This standard replaces the previous standard release case. GB/T 12715-1991. Chromosome aberrations biological dose estimation method

1 Scope

This standard gives a dose of ionizing radiation-induced chromosomal aberrations in human peripheral blood lymphocytes - established with effect curve and estimate its students It was dose approach. This standard applies to a relatively homogeneous body external irradiation dose by accident according to staff estimates. This standard also applies to cases of a uniform dose of external radiation and burn body estimates. This standard does not apply to fractionated irradiation, the cumulative long-term low-dose radiation and internal radiation biological dose estimation.

2 Terms and definitions

The following terms and definitions apply to this standard. 2.1 Biological dosimeter biologicaldosimeter To estimate radiation dose of biological systems, there is a certain clearance between the quantitative reaction of the biological system by irradiation with radiation dose Department, which can be used for estimating radiation doses. 2.2 Dose - effect curve dose-responsecurve A substance or biological system by the presence of some kind of quantitative relationship between radiation dose and the response after irradiation, can be fitted to both fitness When the mathematical models, and prepare the corresponding scale curve, called the dose - response curve, which can be used to estimate radiation doses. 2.3 Chromosome chromosome Vector genes. Present in the nucleus when cells divide, under the effect of colored basic dye darker. The DNA (DNA), a small amount of protein and ribonucleic acid (RNA) components. 2.4 Chromosome aberrations chromosomeaberration The number of normal and abnormal structure of chromosomes in the factors of physical, chemical or biological on. 2.5 Chromosome aberrations chromosome-typeaberration Irradiation in Go or G1 phase of the cell, since before DNA synthesis, a single chromosome to the exercise of its function, then induced Distortion, after S phase replication, involves the formation of two single chromosomal aberrations, including non-centromeric fragments, small body, no centromere Ring, ring centromere, centromere or double body, inversions, translocations, insertions and deletions and the like. 2.6 Chromatid aberrations chromatid-typeaberration Most cells in the S phase and G2 phase irradiated cells according to the subject, has been subjected to DNA synthesis, already formed two separate monomers. The In only induced chromatid aberrations, including chromatid breaks, chromatid exchange, and the like chromatid chromatid gap and gap. 2.7 Unstable chromosome aberrations unstablechromosomeaberration Unstable chromosome aberrations including non-centromeric fragments, small body, no centromere rings, dicentric ring body and the centromere. No centromere fragments, small body, no centromere ring, because no centromere on the spindle orientation can not be quickly lost from the dividing cells. Dicentric ring body and the centromere is often formed during anaphase chromosome bridge or tetraploid and often lead to cell death caused by the above five abnormal
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