GB/T 21610-2025 English PDF

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 21610-2025	RFQ	ASK	3 days	Chemicals - Test method of rodent dominant lethal	Valid
GB/T 21610-2008	169	Add to Cart	3 days	Test method of rodent dominant lethal for chemicals	Valid

Basic data

Standard ID: GB/T 21610-2025 (GB/T21610-2025)
Description (Translated English): Chemicals - Test method of rodent dominant lethal
Sector / Industry: National Standard (Recommended)
Date of Implementation: 2025-12-01
Older Standard (superseded by this standard): GB/T 21610-2008

GB/T 21610-2008: Test method of rodent dominant lethal for chemicals

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Test method of rodent dominant lethal for chemicals ICS 13.300; 11.100 A80 National Standards of People's Republic of China Chemicals Rodent dominant lethal test methods Posted 2008-04-01 2008-09-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released

Foreword

This revised standard adopts the United Nations Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 478 "Rodent dominant cause Death Test "(1997) (in English). This standard OECD Chemicals Test Method No. 478 compared with the following differences. --- To OECD Chemicals Test Method No. 478 were editorial changes; --- Increased the preamble; --- Rearing environment contextually GB 14924-2001 and GB 14925-2001 provisions. This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points. This standard is drafted by. China Center for Disease Control and Prevention of Occupational Health and Poison Control. Participated in the drafting of this standard. Tianjin Inspection and Quarantine Institute of Science and Technology, Hunan labor health occupational disease prevention. The main drafters of this standard. Ai Wei Wu, Chao-lin, Xu Jianning, Zheng Lin, Sun Jinxiu Shi Xiao , Zhang Yuan, in Chi Rui, Lining Tao, Lu Dan. Chemicals Rodent dominant lethal test methods

1 Scope

This standard specifies the test object, the terms and definitions, basic test principle, test procedures Rodent dominant lethal test results Review Price, test reports and interpretation of results. This standard is applicable to the detection of chemical damage to the overall rodent germ cell chromosomes.

2 Normative references

The following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard. GB 14924-2001 standard laboratory animals and feed GB 14925-2001 Laboratory Animal Facilities and Environment Chemical Abstracts Registry Number CAS No. 50-18-0 Chemical Abstracts Registry Number CAS No. 51-18-3 Chemical Abstracts Registry Number CAS No. 62-50-0 Chemical Abstracts Registry Number CAS No. 6055-19-2

3 Terms and Definitions

3.1 It means causing the embryo or fetal death. When this effect was produced by exposure to a chemical test sample showed reproductive effects in laboratory animals Organizations, generally considered to be a result cause reproductive changes in chromosome structure and number of cells. Does not rule out gene mutations and toxic effects. 3.2 Refers to the development of sperm or eggs in the physical or chemical factors, chromosomal damage occurs, thus resulting in the development of a fertilized egg death. Fertilization does not cause disorder, but cause of death of a fertilized egg.

4 test purposes

This trial is a germ cell mutagenicity test for detecting the overall rodent germ cells chromosomal aberrations, further confirmed the body Field test, or other test systems to obtain positive results in order to evaluate the test sample can reach the gonads produce genetic damage.

5 Test Fundamentals

Through appropriate means to make contact with a test sample of male animals, and then exposed and not without a mated female animals mating, mating end After removing the female animals. Female animals were sacrificed after half of pregnancy, cut open the abdominal cavity, the uterus is removed, check the number of implants on both sides of the uterus (implantation Number), as early as the number of stillbirths and late stillbirth numbers and number of live births. Male animal is in a certain interval of time and then another group without the exposure and not mated Female animals mate, so a total number of batches, to ensure that the sperm cover a period (6 weeks to 9 weeks).

6 Test Procedure

6.1 test sample The test sample should be freshly prepared. Unless there is information to indicate that this solution (or emulsion, suspension, etc.) preservation of stability. Solid test ......

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