GB/T 21605-2025 English PDF

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 21605-2025	RFQ	ASK	3 days	Chemicals - Test method of acute inhalation toxicity	Valid
GB/T 21605-2008	489	Add to Cart	4 days	Chemicals -- Test method of acute inhalation toxicity	Valid

Basic data

Standard ID: GB/T 21605-2025 (GB/T21605-2025)
Description (Translated English): Chemicals - Test method of acute inhalation toxicity
Sector / Industry: National Standard (Recommended)
Date of Implementation: 2025-12-01
Older Standard (superseded by this standard): GB/T 21605-2008

GB/T 21605-2008: Chemicals -- Test method of acute inhalation toxicity

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Chemicals. Test method of acute inhalation toxicity ICS 13.300; 11.100 A80 National Standards of People's Republic of China Chemical Acute inhalation toxicity testing Posted 2008-04-01 2008-09-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released

Foreword

This revised standard adopts the United Nations Organisation for Economic Co-operation and Development (OECD) Chemicals Test Method No. 403 "acute inhalation toxicity test Method "(1981.2) and No. 433 "acute inhalation toxicity test methods --- Fixed Dose Method" (2002.2) (in English). This standard OECD Chemicals Test Method No. And No. 403 433 compared with the following differences. --- To OECD Chemicals Test Method No. And No. 403 433 were editorial changes; --- Increased the preamble; --- Added Appendix section. Appendix B of this standard is a normative appendix; Appendix A, Appendix C is informative appendix. This standard is managed by the National Standardization Technical Committee chemicals dangerous (SAC/TC251) and focal points. This standard is drafted by. China Center for Disease Control and Prevention of Occupational Health and Poison Control. Participated in the drafting of this standard. Tianjin Inspection and Quarantine Institute of Science and Technology, Anhui Province Center for Disease Control and Prevention. The main drafters of this standard. Sun Jinxiu, Chao-lin, Ai Wei Wu Lin Zheng Hou Fenxia, \u200b\u200bLee Frost, Zhang Yuan, in Chi Rui, Lining Tao, Xing Weiping, Wang Wei, Liu Yan. Chemical Acute inhalation toxicity testing

1 Scope

This standard specifies the test animals Acute inhalation toxicity testing purposes, terms and definitions, basic test principle, test methods, the test report And interpretation of results. This standard applies to the evaluation of gas, acute volatile material or aerosol/particulate matter and other chemicals inhalation toxicity.

2 Terms and definitions

2.1 Laboratory Animal short time (24h within) sustained inhale a test sample can be inhaled, the health damage effect occurs in the short term. 2.2 Within a certain time after the test sample caused by inhalation of the test animals died probability of occurrence of 50% concentration in unit volume of air The mass of the test sample gas (mg/m3) is represented. 2.3 Chemical poison the relationship between the dose of a particular group in the incidence of mass effect.

3 test purposes

Chemicals detected in experimental animals acute inhalation toxicity and strength for subacute (slow) and other toxicity test provides dose selection Basis.

4 Test the basic principles

Each test group of animals within a certain period of Inhaling the test sample, the concentration of exposure can be determined by the choice of pre-test. Contamination After the observation of toxicity and death of animals. Death during the test animals subjected to necropsy at the end of the test surviving animals to be at Death and gross anatomy.

5 Test methods

5.1 Experimental Animals Preferred healthy adult mice (18g ~ 22g) or rat (180g ~ 220g), can also be used other sensitive animals. With each dose group sex The difference between the body weight of no more than 20% of the average weight. Before the test animals to adapt to the 3d ~ 5d time at least in the test environment. 5.2 dose design According to the requirements of the selected method, it should be located 4 to 5 dose groups, in principle, each animal is usually 10, male and female. Each dose group From the size of the test substance to the toxicity and appropriate animal death, usually in large groups, and a lesser amount from the pre-test animals. If the drug test sample Is very low, it may also have a limited method, which uses 20 animals (male and female), the general 2000mg/m3 inhalation 4h, not resulting in death of animals Death, no more multiple doses of acute inhalation toxicity test. If desired do 5000mg/m3 or higher concentrations of respirable 4h, or The maximum concentration possible test. 5.3 Exposure Exposure may be exposed to static type exposure method or method acting. ......

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