GB/T 15670.8-2017 English PDF

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GB/T 15670.8-2017: Toxicological test methods for pesticides registration -- Part 8: Acute eye irritation/corrosion test
Status: Valid

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 15670.8-2017	139	Add to Cart	3 days	Toxicological test methods for pesticides registration -- Part 8: Acute eye irritation/corrosion test	Valid

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Basic data

Standard ID: GB/T 15670.8-2017 (GB/T15670.8-2017)
Description (Translated English): Toxicological test methods for pesticides registration -- Part 8: Acute eye irritation/corrosion test
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: B17
Classification of International Standard: 65.100
Word Count Estimation: 7,738
Date of Issue: 2017-07-12
Date of Implementation: 2018-02-01
Older Standard (superseded by this standard): GB/T 15670-1995 Partly
Quoted Standard: GB 14925
Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China
Summary: This standard specifies the basic principles, methods and requirements for acute eye irritation / corrosivity testing. This standard applies to acute eye irritation / corrosivity tests for pesticide registration.

GB/T 15670.8-2017: Toxicological test methods for pesticides registration -- Part 8: Acute eye irritation/corrosion test

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Toxicological test methods for pesticides registration. Part 8. Acute eye irritation/corrosion test ICS 65.100 B17 National Standards of People's Republic of China Partially replace GB/T 15670-1995 Pesticide registration Toxicology test methods Part 8. Acute eye irritation/corrosivity test Part 8.Acuteeyeirritation/corrosiontest 2017-07-12 Posted 2018-02-01 implementation General Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China China National Standardization Administration released

Foreword

GB/T 15670 "pesticide registration toxicology test method" is divided into the following sections. --- Part 1. General principles; --- Part 2. Acute oral toxicity test Horn's method; --- Part 3. Acute oral toxicity test sequential method; --- Part 4. Acute oral toxicity test probability unit method; --- Part 5. Acute dermal toxicity test; --- Part 6. Acute inhalation toxicity test; --- Part 7. Skin irritation/corrosivity test; --- Part 8. Acute eye irritation/corrosiveness test; --- Part 9. Skin allergy (sensitization) test; --- Part 10. Short-term repeated oral toxicity (28 days) toxicity test; --- Part 11. Short-term repeated transdermal (28 days) toxicity test; --- Part 12. Short-term repeated inhalation exposure (28 days) toxicity test; --- Part 13. Subchronic toxicity test; --- Part 14. bacterial recovery mutation test; --- Part 15. In vivo mammalian bone marrow polychromatic erythrocyte micronucleus test; --- Part 16. In vivo mammalian bone marrow cell chromosome aberration test; --- Part 17. Mammalian spermatogonial/spermatocyte chromosome aberration test; --- Part 18. Rodent dominant lethality test; --- Part 19. In vitro mammalian chromosome aberration test; --- Part 20. In vitro mammalian cell gene mutation test; --- Part 21. In vivo mammalian hepatocyte extracellular DNA synthesis (UDS) test; --- Part 22. DNA damage and repair in vitro mammalian cells/DNA synthesis test outside the program; --- Part 23. Teratogenicity test; --- Part 24. Two generations of reproductive toxicity test; --- Part 25. Acute delayed neurotoxicity test; --- Part 26. Chronic toxicity test; --- Part 27. Carcinogenicity test; --- Part 28. Chronic toxicity and carcinogenicity combined test; --- Part 29. Metabolism and toxicokinetic tests. This section GB/T 15670 Part 8. This section drafted in accordance with GB/T 1.1-2009 given rules. Part of this section instead of GB/T 15670-1995 "pesticide registration toxicology test methods." This section GB/T 15670-1995 eye irritation test compared to the main changes are as follows. --- Modify and adjust the standard of the overall structure and layout format; --- Added some chapters (see Chapter 1, Chapter 2, Chapter 3, Chapter 5, 6.1, 6.2.2, Chapter 7 and Chapter 8); --- Modify the number of experimental animals requirements (see 6.2.1,.1995 version 6.3); --- Modify the eye damage rating criteria (see Table 1,.1995 edition of Table 6); --- Modify the eye irritation response classification (see Table 2,.1995 edition of Table 7). This part is proposed by the Ministry of Agriculture of the People's Republic of China. This part of the People's Republic of China Ministry of Agriculture Planting Management Center. This part of the drafting unit. Ministry of Agriculture pesticide test. The main drafters of this section. Qin Yu Hui, Qu 甍 甍, Zhang Liying, Tao Chuanjiang. This part replaces the standards previously issued as. --- GB/T 15670-1995. Pesticide registration Toxicology test methods Part 8. Acute eye irritation/corrosivity test

1 Scope

This section GB/T 15670 specifies the basic principles, methods and requirements of acute eye irritation/corrosivity test. This section is for acute eye irritation/corrosivity test for pesticide registration.

2 Normative references

The following documents for the application of this document is essential. For dated references, only the dated version applies to this article Pieces. For undated references, the latest edition (including all amendments) applies to this document. GB 14925 laboratory animal environment and facilities

3 Terms and definitions

The following terms and definitions apply to this document. 3.1 Eye irritation eyeirritation The reversible inflammatory changes that occurred after the eye surface contacted the test substance recovered completely within 21 days. 3.2 Eye corrosive eyecorrosion Irreversible tissue damage that occurs after the eye surface touches the test substance fails to recover completely within 21 days.

4 test purposes

Determine and assess whether the test article on the mammalian eye irritation or corrosion effect and extent.

5 Test Overview

The test substance was instilled (put in) into one eye conjunctiva of each experimental animal in a single dose, and the untreated eye on the other side was taken as Self-control. During the prescribed time interval, the degree of irritation and corrosion of the animal's eyes was observed and scored to evaluate the effect of the test substance on the eyes The duration of the observation should be sufficient to evaluate the reversibility or irreversibility of the stimulus effect.

6 test methods

6.1 Test substance Liquid test substance generally do not need dilution, the direct use of stock solution, the amount of exposure to 0.1mL. If the test substance is solid or granular, should be research Ground into fine powder, the dose should be 0.1mL or 100mg. Aerosol products need to open the rabbit eyes, 10cm in front of the eye, the rabbit eye alignment ......

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