GB/T 15670.27-2017 English PDF

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GB/T 15670.27-2017: Toxicological test methods for pesticides registration -- Part 27: Carcinogenicity study
Status: Valid

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 15670.27-2017	199	Add to Cart	3 days	Toxicological test methods for pesticides registration -- Part 27: Carcinogenicity study	Valid

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Basic data

Standard ID: GB/T 15670.27-2017 (GB/T15670.27-2017)
Description (Translated English): Toxicological test methods for pesticides registration -- Part 27: Carcinogenicity study
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: B17
Classification of International Standard: 65.100
Word Count Estimation: 10,163
Date of Issue: 2017-07-12
Date of Implementation: 2018-02-01
Regulation (derived from): s Republic of China
Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China

GB/T 15670.27-2017: Toxicological test methods for pesticides registration -- Part 27: Carcinogenicity study

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Toxicological test methods for pesticides registration - Part 27. Carcinogenicity study ICS 65.100 B17 National Standards of People's Republic of China Part of the replacement GB/T 15670-1995 Pesticide registration toxicology test method Part 27. carcinogenic tests Part 27. Carcinogenicitystudy 2017-07-12 released 2018-02-01 Implementation General Administration of Quality Supervision, Inspection and Quarantine of the People 's Republic of China China National Standardization Management Committee released

Foreword

GB/T 15670 "Pesticide registration toxicology test method" is divided into the following parts. - Part 1. General; - Part 2. Acute oral toxicity test; - Part 3. Sequential method of acute oral toxicity test; - Part 4. Acute oral toxicity test probability unit method; - Part 5. Acute percutaneous toxicity test; - Part 6. Acute inhalation toxicity test; - Part 7. Skin irritation/corrosivity test; - Part 8. Acute eye irritation/corrosivity test; - Part 9. Skin allergy (sensitization) test; - Part 10. Short-term repeated oral exposure (28 days) toxicity test; - Part 11. Short term repeated percutaneous exposure (28 days) toxicity test; - Part 12. Short-term repeated inhalation exposure (28 days) toxicity test; - Part 13. Subchronic toxicity test; - Part 14. Bacterial response mutations; - Part 15. Micronucleus test of mammalian bone marrow polychromatic erythrocytes; - Part 16. Chromosome aberration test of mammalian bone marrow cells in vivo; - Part 17. Chromosome aberration of spermatogonia/spermatocytes in mammals; - Part 18. Sexual lethal test of rodents; - Part 19. In vitro mammalian cell chromosome aberration test; - Part 20. In vitro mammalian cell gene mutation test; Part 21. Systemic DNA synthesis (UDS) test for mammalian hepatocytes in vivo; - Part 22. DNA damage and repair/programmed DNA synthesis in mammalian cells in vitro; - Part 23. Teratogenic tests; - Part 24. Two generations of reproductive toxicity tests; - Part 25. Acute delayed neurotoxicity test; - Part 26. Chronic toxicity test; - Part 27. Cancer test; - Part 28. Chronic toxicity and carcinogenesis trials; - Part 29. Metabolic and toxic kinetic tests. This part is part 27 of GB/T 15670. This part is drafted in accordance with the rules given in GB/T 1.1-2009. This part of the part of GB/T 15670-1995 "pesticide registration toxicology test method". This part of the GB/T 15670-1995 compared with the cancer test part of the main changes are as follows. --- modify and adjust the overall structure and layout format; - Added some chapters (see Chapter 1, Chapter 2, Chapter 3, Chapter 5, 6.2.3, 7.2.3 and Chapter 8); - modified the requirements for the test substance (see 6.1.1,.1995 edition 17.5.1); - modified the requirements for laboratory animals (see 6.2.2,.1995, 17.3.3). This section is made by the Ministry of Agriculture of the People's Republic of China. This part is headed by the Department of Agriculture and Plant Management of the People's Republic of China. This part of the drafting unit. Ministry of Agriculture Pesticide Testing Institute. The main drafters of this part. Wang Jie, Tao Chuanjiang, Li Zenggang, Song Hongyu, Zhang Liying, Qu 甍 甍. This part of the previous version of the standard to replace the release of the situation. --- GB/T 15670-1995. Pesticide registration toxicology test method Part 27. carcinogenic tests

1 Scope

This part of GB/T 15670 specifies the basic principles, methods and requirements for carcinogenic trials. This section applies to carcinogenic tests for pesticide registration.

2 normative reference documents

The following documents are indispensable for the application of this document. For dated references, only the dated edition applies to this article Pieces. For undated references, the latest edition (including all modifications) applies to this document. Laboratory Animal Environment and Facilities

3 terms and definitions

The following terms and definitions apply to this document. 3.1 Chemical carcinogenesis Chemical substances cause tumor incidence and/or type of increase, the effect of shortening latency. 3.2 Chemical carcinogen chemicalcarcinogen Can make the body produce tumors, tumor incidence or tumor latency shortened chemical substances.

4 Purpose of the test

Through a certain way to give experimental animals of different doses of the test substance to observe the animals in the near life time tumor occurrence, To assess the chemical carcinogenic effects of long-term exposure to the test substance on animals.

5 Test Overview

The test substance was repeatedly administered orally, transdermally or via respiratory tract for most of the normal life cycle of the experimental animal. The number of tumors, type, place of occurrence, time of occurrence, and by histopathological examination to clarify whether the test substance is carcinogenic.

6 test method

6.1 Test substance Before starting this test, you should be aware of the various materials available to the subject. Including the trade name and other names of the test substance (including CAS ), Physical, chemical, structural, molecular and relative molecular mass, storage methods, analytical methods and chemical stability of the test substance. ......

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